Ramamoorthy Group

Avanti is now selling 14:0 PE-DTPA(Cu) lipids. The addition of these lipids to their catalog was inspired by exciting research performed in our lab! This is outstanding vallidation that the research done in the Ramamoorthy lab is extremely important and relevant in both the NMR and biological fields. A detailed pdf brochure can be downloaded by following this link.

"Inclusion of copper (Cu²⁺) ions in bicelles in the form of a lipid chelate resulted in a 10-fold T₁ reduction and 2.7-fold increase in S/N of spectra for static experiments. This improvement would allow 2D experiments on membrane proteins in aligned lipid bilayers that typically take 3 days to be completed in <1.5 days. The technique is particularly beneficial to the study of membrane disrupting/permeating systems (such as antimicrobial peptides, toxins, amyloid peptides, and fusion peptides) whose concentration cannot be increased, as they result in nonlamellar conditions."