Lab Members‎ > ‎

Meng Zhang


zmzt@umich.edu

Department of Chemistry
930 N. University Ave.
Ann Arbor, MI, 48109

(734) 763-9318



Education

  •        2007 - 2011 B.S. in Chemistry, Nankai University, China
  •        2011 - Present Ph.D. Candidate in Chemistry, University of Michigan, USA

Publications

  •  Meng Zhang, Stéphanie V Le Clair, Sang-Choul Im, Lucy Waskell, and Ayyalusamy Ramamoorthy, Insights into the Role of Substrates on the Interaction between Cytochrome b5 and Cytochrome P450 2B4 by NMR, Sci. Rep. 2015, 5: 8392
  • Meng Zhang, Rui Huang, Sang-Choul Im, Lucy Waskell, and Ayyalusamy Ramamoorthy, Effects of Membrane Mimetics on Cytochrome P450 – Cytochrome b5 Interactions Characterized by NMR Spectroscopy, J Biol Chem. 2015, 290(20):12705-18
  • Meng Zhang, Rui Huang, Rose Ackermann, Sang-Choul Im, Lucy Waskell, Anna Schwendeman and Ayyalusamy Ramamoorthy, Reconstitution of Cytb5–CytP450 Complex in Nanodiscs for Structural Studies by NMR. Angewandte Chemie in press
  • Meng Zhang, Stéphanie V Le Clair, Yamamoto Kazutoshi, Rui Huang, Sang-Choul Im, Lucy Waskell, and Ayyalusamy Ramamoorthy, The cytb5 linker region modulates the interaction with CYP2B4 both in their soluble and transmembrane domains. manuscript in preparation
  • Meng ZhangRui Huang, Sang-Choul Im, Lucy Waskell, and Ayyalusamy Ramamoorthy, High-resolution structural interaction between cytochrome P450 and the FMN domain of cytochrome P450 reductase probed by NMR Spectroscopy, manuscript in preparation
  • Rui Huang, Meng Zhang, Freeborn Rwere, Lucy Waskell, and Ayyalusamy Ramamoorthy, Kinetic and Structural Characterization of the Interaction between the FMN Binding Domain of Cytochrome P450 Reductase and Cytochrome c, J Biol Chem. 2015 ,290(8):4843-55
  • Rui Huang, Meng Zhang, Yamamoto Kazutoshi, Sang-Choul Im, Lucy Waskell, and Ayyalusamy Ramamoorthy, Dynamic interaction between membrane bound full length Cytochrome P450 and FMN binding domain of CPR observed by solid-state NMR spectroscopy. Manuscript in preparation
  • Rui Huang, Yamamoto Kazutoshi, Meng Zhang, Nataliya Popovych, Sang-Choul Im, Lucy Waskell, and Ayyalusamy Ramamoorthy, Probing the transmembrane structure and dynamics of microsomal cytochrome P450 reductase by solid-state NMR. Biophys. J.106(2014), 2126-2133. 
  • Huimin Li, Jingmin Zhou, Wei Shi, Xuejing Zhang, Zhenjie Zhang, Meng Zhang, and Peng Cheng, Structural Diversity of Four New Metal-Organic Frameworks with a Curving Tetracarboxdiimide Dicarboxylic Acid. CrystEngComm, 2014,16, 834-841

Presentations

  • “Effect of membrane on the structure and function of a membrane-bound rabbit Cytochrome P450 2B4”, the 2013 GLDMDG meeting, Toledo, Ohio, May 9th – May 10th, 2013
  •  “NMR studies of interaction between Cytochrome P450 2B4 and the FMN binding domain of Cytochrome P450 Reductase”, the 18th International Conference on Cytochrome P450, Seattle, Washington, June 18th – 23rd, 2013
  • “Membrane preference of a membrane-bound rabbit Cytochrome P450 2B4 and its effect on CYP 2B4 structure and function indicating the presence of a hydrophobic substrate channel within the protein”, the 6th Vaughan Symposium, Ann Arbor, Michigan, July 12th, 2013
  • “NMR Investigations of the Roles of Membrane and CYP-2B4 transmembrane-domain in the Interaction between CYP-2B4 and Its Redox Partners”, the 55th Experimental Nuclear Magnetic Resonance Conference, Boston, Massachusetts, March 22nd – 28th, 2014
  • Roles of Membrane and Substrate on the Biological Function of Cytochrome P450”, the 7th Vaughan Symposium, Ann Arbor, Michigan, July 30th, 2014
  • “Incorporation of the CYP2B4-cytb5 complexes into nanodiscs characterized by NMR”, the the 56th Experimental Nuclear Magnetic Resonance Conference, Pacific Grove, California, April 19th – 24th, 2015; the 2015 GLDMDG meeting, Ann Arbor, Michigan, May 7th – May 8th, 2015
  • “Solution NMR study reveals the structure and dynamics of complex formation between cytochrome P450 and its redox partners”, the 2016 GLDMDG meeting, Chicago, May 5th – May 6th, 2016

Oral Presentations

  • “Investigating the effect of membranes on complex formation between cytochrome P450 and cytochrome b5”, the Recent Advances in Biomolecular NMR Spectroscopy international symposium, Ann Arbor, Michigan, April 16th – 17th, 2016

Academic Award

  • Student Travel Award at 55th Experimental Nuclear Magnetic Resonance Conference (March 2014)
  • Chemistry Winter Fellowship by Department of Chemistry, University of Michigan (Winter 2015)
  • The Robert W. Parry Award for Research by Department of Chemistry, University of Michigan (Summer 2015)
  • The Margaret & Herman Sokol Graduate Summer Research Fellowship by Department of Chemistry, University of Michigan (Summer 2016)
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