zmzt@umich.edu
Department of Chemistry
930 N. University Ave.
Ann Arbor, MI, 48109
(734) 763-9318
Education
- 2007
- 2011 B.S. in Chemistry, Nankai University, China
- 2011
- Present Ph.D. Candidate in Chemistry, University of Michigan, USA
Publications
- Meng Zhang, Stéphanie V Le Clair, Sang-Choul Im,
Lucy Waskell, and Ayyalusamy Ramamoorthy, Insights into the Role of Substrates on
the Interaction between Cytochrome b5
and Cytochrome P450 2B4 by NMR, Sci. Rep.
2015, 5: 8392
- Meng Zhang, Rui Huang, Sang-Choul Im, Lucy Waskell,
and Ayyalusamy Ramamoorthy, Effects of Membrane Mimetics on Cytochrome P450 –
Cytochrome b5 Interactions
Characterized by NMR Spectroscopy, J Biol
Chem. 2015, 290(20):12705-18
- Meng Zhang, Rui Huang, Rose Ackermann, Sang-Choul Im, Lucy
Waskell, Anna Schwendeman and Ayyalusamy Ramamoorthy, Reconstitution of Cytb5–CytP450 Complex in Nanodiscs
for Structural Studies by NMR. Angewandte
Chemie in press
- Meng Zhang, Stéphanie V Le Clair, Yamamoto
Kazutoshi, Rui Huang, Sang-Choul Im, Lucy Waskell, and Ayyalusamy Ramamoorthy, The
cytb5 linker region
modulates the interaction with CYP2B4 both in their soluble and transmembrane
domains. manuscript in preparation
- Meng Zhang, Rui Huang, Sang-Choul Im, Lucy Waskell, and Ayyalusamy Ramamoorthy, High-resolution structural interaction between cytochrome P450 and the FMN domain of cytochrome P450 reductase probed by NMR Spectroscopy, manuscript in preparation
- Rui
Huang, Meng Zhang, Freeborn Rwere, Lucy
Waskell, and Ayyalusamy Ramamoorthy, Kinetic and Structural Characterization of
the Interaction between the FMN Binding Domain of Cytochrome P450 Reductase and
Cytochrome c, J Biol Chem. 2015
,290(8):4843-55
- Rui
Huang, Meng Zhang, Yamamoto
Kazutoshi, Sang-Choul Im, Lucy Waskell, and Ayyalusamy Ramamoorthy, Dynamic interaction between membrane bound full length
Cytochrome P450 and FMN binding domain of CPR observed by solid-state NMR
spectroscopy. Manuscript in
preparation
- Rui
Huang, Yamamoto Kazutoshi, Meng Zhang,
Nataliya Popovych, Sang-Choul Im, Lucy Waskell, and Ayyalusamy Ramamoorthy, Probing the transmembrane structure and dynamics
of microsomal cytochrome P450 reductase by solid-state NMR. Biophys. J.106(2014), 2126-2133.
- Huimin
Li, Jingmin Zhou, Wei Shi, Xuejing Zhang, Zhenjie Zhang, Meng Zhang, and Peng Cheng, Structural
Diversity of Four New Metal-Organic Frameworks with a Curving
Tetracarboxdiimide Dicarboxylic Acid. CrystEngComm, 2014,16, 834-841
Presentations - “Effect
of membrane on the structure and function of a membrane-bound rabbit Cytochrome
P450 2B4”, the 2013 GLDMDG meeting, Toledo, Ohio, May 9th – May 10th,
2013
- “NMR studies of interaction
between Cytochrome P450 2B4 and the FMN binding domain of Cytochrome P450
Reductase”, the 18th
International Conference on Cytochrome P450, Seattle, Washington, June 18th
– 23rd, 2013
- “Membrane preference of a
membrane-bound rabbit Cytochrome P450 2B4 and its effect on CYP 2B4 structure
and function indicating the presence of a hydrophobic substrate channel within
the protein”, the 6th Vaughan Symposium, Ann Arbor, Michigan, July
12th, 2013
- “NMR
Investigations of the Roles of Membrane and CYP-2B4 transmembrane-domain in the
Interaction between CYP-2B4 and Its Redox Partners”, the 55th Experimental
Nuclear Magnetic Resonance Conference, Boston, Massachusetts, March 22nd – 28th, 2014
- “Roles of Membrane and Substrate on the Biological Function of Cytochrome
P450”, the
7th Vaughan Symposium, Ann Arbor, Michigan, July 30th,
2014
- “Incorporation of the
CYP2B4-cytb5 complexes
into nanodiscs characterized by NMR”, the the
56th Experimental Nuclear Magnetic Resonance Conference, Pacific
Grove, California, April 19th
– 24th, 2015; the 2015 GLDMDG meeting, Ann Arbor, Michigan, May 7th
– May 8th, 2015
- “Solution NMR study reveals the structure and
dynamics of complex formation between cytochrome P450 and its redox partners”,
the
2016 GLDMDG meeting, Chicago, May 5th – May 6th, 2016
Oral Presentations - “Investigating
the effect of membranes on complex formation between cytochrome P450 and
cytochrome b5”, the Recent
Advances in Biomolecular NMR Spectroscopy international symposium, Ann Arbor,
Michigan, April 16th – 17th, 2016
Academic Award - Student Travel Award at 55th Experimental Nuclear Magnetic Resonance
Conference (March 2014)
- Chemistry Winter Fellowship by Department of Chemistry,
University of Michigan (Winter 2015)
- The
Robert W. Parry Award for Research by Department of Chemistry, University of
Michigan (Summer 2015)
- The Margaret & Herman Sokol Graduate Summer Research Fellowship by Department of Chemistry, University of Michigan (Summer 2016)
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