Lab Members‎ > ‎

Vojc Kocman

vkocman@umich.edu 

Biophysics Department
930 N. University Ave.
Ann Arbor, MI, 48109

(734) 763-9318

Education

9th June 2017          Ph.D. in Chemical Science

Doctoral thesis:        “Structural studies of guanine rich oligonucleotides connected to autism”

Institutions:             National Institute of Chemistry, University of Ljubljana, Faculty of Chemistry and Chemical Technology, Ljubljana, Slovenia


Field:                       Structural determination of nucleic acids

                                         Mentor:                       Prof. Dr. Janez Plavec

Research Projects

Former projects:
Structural studies of G-rich DNA that form structures different from G-quadruplexes.

Curent projects:
NMR and biophysical studies involving nanodiscs and amyloid beta proteins. Characterizing interactions between nanodiscs and DNA/small molecules. 

Publications

 

1.    Hadzi, S., Kocman, V., Oblak, D., Plavec, J. and Lah, J., Energetic Basis of AGCGA‐Rich DNA Folding into a Tetrahelical Structure, Angew. Chem. Int. Ed.  (58) 8, (2019), 2387. https://doi.org/10.1002/anie.201813502


2.      Kocman, V. and Plavec, J, Tetrahelical structural family adopted by AGCGA-rich regulatory DNA regions, Nat. Commun., 8, (2017), art. no. 15355. https://doi.org/10.1038/ncomms15355

 

3.       Kocman, V. and Plavec, J, A tetrahelical DNA fold adopted by tandem repeats of alternating GGG and GCG tracts, Nat. Commun., 5, (2014), art. no. 5831. https://doi.org/10.1038/ncomms6831


Oral Presentations and Posters

Oral presentations:

 

October, 2017          Oral presentation entitled “AGCGA-quadruplex core architecture and the duplex pre-fold                                         model” at the conference “Advances in noncanonical nucleic acids: ANNA 2017” held in                                         Bled, Slovenia

May, 2017                Oral presentation entitled “AGCGA-quadruplexes a novel tetrahelical structural family” at the                                   conference “G4thering - 6th International Meeting on Quadruplex Nucleic Acids” held in                                           Prague, Czech Republic

February, 2015         Oral presentation entitled “A tetrahelical DNA fold not stabilized by G-quartets” at the                                                   conference “Magnetic Moments in Central Europe 2015” held in Krynica-Zdrój, Poland

Poster presentations:

Conference:                  Adriatic NMR

Title:                              Multiple possible folds in the regulatory region of the PLEKHG3 gene

Location and Date:       June, 2018; Mali Ston, Croatia

Authors:                                   Vojč Kocman, Janez Plavec

Conference:                  International Symposium on Chemical Biology

Title:                              AGCGA-quadruplexes a third tetrahelical DNA structural family

Location and Date:       Jan, 2018; Geneva, Switzerland

Authors:                                   Vojč Kocman, Janez Plavec

Conference:                  NMR: a tool for biology Xth

Title:                              Uncommon DNA structural motifs result in uncommon NMR properties

Location and Date:       Jan, 2017; Paris, France

Authors:                                   Vojč Kocman, Janez Plavec

Conference:                  Magnetic moments in Central Europe 2017

Title:                            Tetrahelical structures stabilized by GAGA-quartets, minor and major groove GCGC-quartets and G-G pairs in N1-carboniy symmetric geometry

Location and Date:       March 2017; Budapest, Hungary

Authors:                                   Vojč Kocman, Janez Plavec

Conference:                  Advances in noncanonical nucleic acids: ANNA 2016

Title:                              Tetrahelical DNA folds that lack G- or GCGC-quartets adopted by G-rich sequences

Location and Date:       May, 2016; Ljubljana, Slovenia

Authors:                                   Vojč Kocman, Janez Plavec

Conference:                  G4thering - 5th International Meeting on Quadruplex Nucleic Acids

Title:                              A G-rich sequence adopts a tetrahelical DNA fold different from G-quadruplexes

Location and Date:       May, 2015; Bordeaux, France

Authors:                                   Vojč Kocman, Janez Plavec

Conference:                  XVIth Symposium on Chemistry of Nucleic Acid Components

Title:                              DNA oligonucleotides with alternating GGG and GCG tracts adopt a tetrastrand fold stabilized by noncanonical base pairs

Location and Date:       September, 2014; Český Krumlov, Czech Republic

Authors:                                   Vojč Kocman, Janez Plavec

Conference:               Advanced magnetic resonance: methods and applications. Combined with the workshop New frontiers in sensitivity for EPR spectroscopy: from biological cells to nanomaterials

Title:                              Cytosine residues in a G-rich region lead to formation of noncanonical structures

Location and Date:       September, 2013; Frauenchiemsee, Germany          

Authors:                                   Vojč Kocman, Janez Plavec

Conference:                  Trends in biomolecular structure: from chemistry to function

Title:                              Noncanonical structures of G-rich regions with GCG repeats

Location and Date:       October, 2013; Ljubljana, Slovenia  

Authors:                                   Vojč Kocman, Janez Plavec

Conference:                  4th International Meeting on G-quadruplex Nucleic Acids

Title:                              Noncanonical structures of G-rich regions which also contain cytosine residues

Location and Date:       July, 2013; Singapore, Singapore     

Authors:                                   Vojč Kocman, Primož Šket, Janez Plavec

Academic Awards

November, 2017      Recipient of the Pregl Award, awarded by the National Institute of Chemistry (Slovenia), for                                     the exceptional PhD thesis in the field of chemistry or other related subjects

 

June, 2014             Award for best poster presentation by a young scientist at the XVIth Symposium on Chemistry                                 of Nucleic Acid Components held in Český Krumlov, Czech Republic