Lab Members‎ > ‎

Bikash Ranjan Sahoo

bsahoo@umich.edu  

Department of Chemistry and Biophysics
University of Michigan 
930 North University Avenue 
Ann Arbor, Michigan 48109-1055
Phone: (734) 647-6572

Education

Ph.D. (Biophysics)        Oct 2013 - Sep 2016  (Osaka University, Japan)

           

Positions

 Apr 2017 - Present       Postdoctoral fellow at University of Michigan, USA.

Oct 2016 - Mar 2017     Research Scientist at RIKEN Brain Science Institute, Japan.

Aug 2010 - Mar 2013     Senior Research Fellow, NAIP, ICAR, India.

Research interest

           Protein misfolding and aggregation are a hallmark of various human diseases including several aging diseases such as Alzheimer's disease and type-II diabetes. The molecular basis of protein misfolding and aggregation and their pathological effects are poorly understood due to the involvement of a complex cellular pathway. Several cellular co-factors are known to modulate such protein aggregation including cell-membrane. In this lab, we are using peptide- or polymer-encapsulated lipid-nanodiscs as a model membrane system to explore the role of cell-membrane in modulating protein aggregation. We are employing an integrated experimental and computational approach that includes neuroscience, chemical biology, and structural biology to disclose the structural basis of amyloid formation in a complex cellular environment. The research findings could aid in the development of potential therapeutic strategies against several unnerving human diseases. 

Publications

(Selected)

BR Sahoo, T Genjo, T Watanabe-Nakayama, A Stoddard, T Ando, K Yasuhara, CA Fierke, A Ramamoorthy. Cationic polymethacrylate-copolymer acts as an agonist for beta-amyloid and antagonist for amylin fibrillation. Chemical Science DOI: 10.1039/c8sc05771k (2019)

BR Sahoo, T Genjo, M Bekier, SJ Cox, AK Stoddard, M Ivanova, K Yasuhara, C Fierke, Y Wang, A Ramamoorthy: Alzheimer's amyloid-beta intermediates generated using polymer-nanodiscs. Chem Commun (Camb). (2018) 54:12883-12886.   

BR Sahoo, T Genjo, SJ Cox, AK Stoddard, GM Anantharamaiah, C Fierke, A Ramamoorthy: Nanodisc-forming scaffold protein promoted retardation of amyloid-beta aggregation. Journal of Molecular Biology (2018)  430:4230-4244.  

C Barnaba, BR Sahoo, T Ravula, IM Meza, SC Im, G Anantharamaiah, L Waskell, A Ramamoorthy: Cytochrome-P450 induced ordering of microsomal membranes modulates affinity for drugs. Angewandte Chemie (2018) 57:3391 -3395 

K Yasuhara, J Arakida, T Ravula, SK Ramadugu, BR Sahoo, JI Kikuchi, A Ramamoorthy: Spontaneous lipid nanodisc fomation by amphiphilic polymethacrylate copolymers. Journal of the American Chemical Society (2017) 139:18657-18663 Link

BR Sahoo, K Maruyama, JR Edula, T Tougan, Y Lin, YH Lee, T Horii, T Fujiwara: Bioengineered bovine Cathelicidin-5 with enhanced anticancer and antimicrobial activity. Scientific Reports (2017) 7:44781.

BR Sahoo, T Fujiwara: Membrane mediated antimicrobial and antitumor activity of Cathelicidin 6: Structural insights from molecular dynamics simulation on multi-microsecond scale. PLoS ONE (2016); 11: e0158702.

BR Sahoo, MR Dikhit, GK Bhoi, J Maharana, SK Lenka, PK Dubey, DK Tiwari: Understanding the distinguishable structural and functional features in zebrafish TLR3 and TLR22,and their binding modes with fish dsRNA viruses: an exploratory structural model analysis. Amino Acids (2015); 47: 381-400.

BR Sahoo, J Maharana, MC Patra, GK Bhoi, SK Lenka, PK Dubey, S Goyal, B Dehury, SK Pradhan: Structural and dynamic investigation of bovine folate receptor alpha (FOLR1), and role of ultra-high temperature processing on conformational and thermodynamic characteristics of FOLR1–folate complex. Colloids and surfaces B: Biointerfaces (2014); 121: 307-318.

BR Sahoo, J Maharana, GK Bhoi, SK Lenka, MC Patra, MR Dikhit, PK Dubey, SK Pradhan, BK Behera: A conformational analysis of mouse Nalp3 domain structures by molecular dynamics simulation, and binding sites analysis. Molecular BioSystems (2014); 10: 1104-1116.

BR Sahoo, M Basu, B Swain, J Maharana, MR Dikhit, P Jayasankar, M Samanta: Structural insights of rohu TLR3, its binding site analysis with fish reovirus dsRNA, polyI:C and zebrafish TRIF. International journal of biological macromolecules (2012); 51: 531-543.

 

Access to full-list of publications: http://www.researcherid.com/rid/H-7399-2012

Oral Presentations and Posters

2018        3rd Gateway NMR Conference, Pittsburgh, USA (Best poster award)
2018        32nd Annual Symposium of The Protein Society, Boston, USA (Travel award)
2016        Regulatory Peptide Society, France (Travel award)
2015        Protein Science Society Japan
2015        7th International Peptide Symposium, Singapore
2014        Biophysical Society Japan
2012/13   Indian Science Congress   (Best poster award)

Academic Awards

2018            The FEBS Journal Poster Prize Award, 3rd Gateway NMR Conference, Pittsburgh, USA
2018            The Hans Neurath Outstanding Promise Travel Award, 32nd Annual Symposium of The Protein Society, Boston, USA
2016-2017   Research Scientist, RIKEN Fellowship, Brain Science Institute, RIKEN, Japan
2016            Regulatory Peptide Society "Young Investigator Travel Award", France
2013-2016   Ministry of Education, Culture, Sports, Science, and Technology (MEXT) Scholarship, Japan
2010-2012   Senior Research Fellow, Indian Council of Agricultural Research (ICAR), India
2009-2010   Research Internship, Council of Scientific and Industrial Research (CSIR), India