Ph.D. (Biophysics)        Oct 2013 - Sep 2016  (Osaka University, Japan)

Positions

 Apr 2017 - Present       Postdoctoral fellow at University of Michigan, USA.

Oct 2016 - Mar 2017     Research Scientist at RIKEN Brain Science Institute, Japan.

Aug 2010 - Mar 2013     Senior Reseach Fellow, NAIP, ICAR, India.

            Protein misfolding and aggregation into amyloid fibers happens during ageing and cause diseases like Alzheimer's (AD), Parkinson's ( PD ) and Type 2 Diabetes ( T2D ). Among numerous intrinsic and     extrinsic   factors   that   modulates   the   protein     aggregation,   cell-membrane   is    strongly   associated   with     the   pathogenesis of these   diseases.   We  therefore   would   like to  explore  the   molecular mechanism  of  such aggregation  at   atomistic scale   using   lipid-nanodiscs that provides  a  native    membrane-mimetic   model environment.   We are   integrating a     variety  of   advanced  biophysical  and   computational approaches to track the dynamic structural changes of two major amyloidogenic   peptides  amyloid-beta   ( Aβ )   and   Islet  amyloid   polypeptide  ( IAPP ) that  are connected to  AD and  T2D, respectively.   The  research findings and the high-resolution structure elucidation will be greatly  helpful to develop therapeutic strategies not only for AD and T2D, but also for several devastating neurodegenerative diseases in which amyloids are involved.