bsahoo@umich.edu
Department of Chemistry and Biophysics
University of Michigan
930 North University Avenue
Ann Arbor, Michigan 48109-1055
Phone: (734) 647-6572
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EducationPh.D. (Biophysics) Oct 2013 - Sep 2016 (Osaka University, Japan) Positions Apr 2017 - Present Postdoctoral fellow at University of Michigan, USA. Oct 2016 - Mar 2017 Research Scientist at RIKEN Brain Science Institute, Japan. Aug 2010 - Mar 2013 Senior Research Fellow, NAIP, ICAR, India. Research interest Protein misfolding and aggregation are a hallmark of various human diseases including several aging diseases such as Alzheimer's disease and type-II diabetes. The molecular basis of protein misfolding and aggregation and their pathological effects are poorly understood due to the involvement of a complex cellular pathway. Several cellular co-factors are known to modulate such protein aggregation including cell-membrane. In this lab, we are using peptide- or polymer-encapsulated lipid-nanodiscs as a model membrane system to explore the role of cell-membrane in modulating protein aggregation. We are employing an integrated experimental and computational approach that includes neuroscience, chemical biology, and structural biology to disclose the structural basis of amyloid formation in a complex cellular environment. The research findings could aid in the development of potential therapeutic strategies against several unnerving human diseases.
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Publications(Selected)
BR Sahoo, T Genjo, M Bekier, SJ Cox, AK Stoddard, M Ivanova, K Yasuhara, C Fierke, Y Wang, A Ramamoorthy: Alzheimer's amyloid-beta intermediates generated using polymer-nanodiscs. Chem Commun (Camb). (2018) 54:12883-12886. BR Sahoo, T Genjo, SJ Cox, AK Stoddard, GM Anantharamaiah, C Fierke, A Ramamoorthy: Nanodisc-forming scaffold protein promoted retardation of amyloid-beta aggregation. Journal of Molecular Biology (2018) 430:4230-4244. C Barnaba, BR Sahoo, T Ravula, IM Meza, SC Im, G Anantharamaiah, L Waskell, A Ramamoorthy: Cytochrome-P450 induced ordering of microsomal membranes modulates affinity for drugs. Angewandte Chemie (2018) 57:3391 -3395 K Yasuhara, J Arakida, T Ravula, SK Ramadugu, BR Sahoo, JI Kikuchi, A Ramamoorthy: Spontaneous lipid nanodisc fomation by amphiphilic polymethacrylate copolymers. Journal of the American Chemical Society (2017) 139:18657-18663 Link BR Sahoo, K Maruyama, JR Edula, T Tougan, Y Lin, YH Lee, T Horii, T Fujiwara: Bioengineered bovine Cathelicidin-5 with enhanced anticancer and antimicrobial activity. Scientific Reports (2017) 7:44781. BR Sahoo, T Fujiwara: Membrane mediated antimicrobial and antitumor activity of Cathelicidin 6: Structural insights from molecular dynamics simulation on multi-microsecond scale. PLoS ONE (2016); 11: e0158702. BR Sahoo, MR Dikhit, GK Bhoi, J Maharana, SK Lenka, PK Dubey, DK Tiwari: Understanding the distinguishable structural and functional features in zebrafish TLR3 and TLR22,and their binding modes with fish dsRNA viruses: an exploratory structural model analysis. Amino Acids (2015); 47: 381-400. BR Sahoo, J Maharana, MC Patra, GK Bhoi, SK Lenka, PK Dubey, S Goyal, B Dehury, SK Pradhan: Structural and dynamic investigation of bovine folate receptor alpha (FOLR1), and role of ultra-high temperature processing on conformational and thermodynamic characteristics of FOLR1–folate complex. Colloids and surfaces B: Biointerfaces (2014); 121: 307-318. BR Sahoo, J Maharana, GK Bhoi, SK Lenka, MC Patra, MR Dikhit, PK Dubey, SK Pradhan, BK Behera: A conformational analysis of mouse Nalp3 domain structures by molecular dynamics simulation, and binding sites analysis. Molecular BioSystems (2014); 10: 1104-1116. BR Sahoo, M Basu, B Swain, J Maharana, MR Dikhit, P Jayasankar, M Samanta: Structural insights of rohu TLR3, its binding site analysis with fish reovirus dsRNA, polyI:C and zebrafish TRIF. International journal of biological macromolecules (2012); 51: 531-543. Access to full-list of publications: http://www.researcherid.com/rid/H-7399-2012
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Oral Presentations and Posters2018 3rd Gateway NMR Conference, Pittsburgh, USA (Best poster award) 2018 32nd Annual Symposium of The Protein Society, Boston, USA (Travel award) 2016 Regulatory Peptide Society, France (Travel award) 2015 Protein Science Society Japan 2015 7th International Peptide Symposium, Singapore 2014 Biophysical Society Japan 2012/13 Indian Science Congress (Best poster award)
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Academic Awards2018 The FEBS Journal Poster Prize Award, 3rd Gateway NMR Conference, Pittsburgh, USA 2018 The Hans Neurath Outstanding Promise Travel Award, 32nd Annual Symposium of The Protein Society, Boston, USA 2016-2017 Research Scientist, RIKEN Fellowship, Brain Science Institute, RIKEN, Japan 2016 Regulatory Peptide Society "Young Investigator Travel Award", France 2013-2016 Ministry of Education, Culture, Sports, Science, and Technology (MEXT) Scholarship, Japan 2010-2012 Senior Research Fellow, Indian Council of Agricultural Research (ICAR), India 2009-2010 Research Internship, Council of Scientific and Industrial Research (CSIR), India
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