Lab Members‎ > ‎

Bikash Ranjan Sahoo

bsahoo@umich.edu 

Biophysics
910 N. University Ave.
Ann Arbor, MI, 48109

(734) 763-9318

Education

Ph.D. (Biophysics)        Oct 2013 - Sep 2016  (Osaka University, Japan, MEXT scholarship)

Research student          Apr 2013 - Sep 2016  (Osaka University, Japan, MEXT scholarship)

M.Sc. (Bioinformatics)    Jun 2007 - Jul 2009   (Orissa University of Agriculture & Technology, India)                  

Positions

 Apr 2017 - Present       Postdoctoral fellow at University of Michigan, USA.

Oct 2016 - Mar 2017     Research Scientist at RIKEN Brain Science Institute, Japan.

Aug 2010 - Mar 2013     Senior Reseach Fellow, NAIP, ICAR, India.

Research interest

                  Protein misfolding and aggregation are a well-known cause of several neurodegenerative disorders such as Alzheimer's disease , Parkinson's disease, prion disease etc. Although enormous efforts have been employed to ward off such diseases, the lack of our  understanding of the  mechanism of  amyloid formation,  its structural plasticity, polymorphism,  and kinetic  behavior restricts current therapeutic  progress. In  particular, the  molecular  mechanisms  of  structural  conversion  from a soluble protein to insoluble amyloids have  remained  elusive.  Thus, I am  interested in  studying the mechanistic  and structural basis of amyloid polymorphism (amyloid beta peptides) in the membrane systemI will integrate a  variety of biophysical  methods including  NMR and  ITC with  MD simulation,  and aim to “chase” the dynamic structural changes at the atomic resolution during seeding reaction ( amyloid formation ) in membrane system. The research findings and the high-resolution structure elucidation will be greatly helpful to develop therapeutic strategies for a variety of devastating neurodegenerative diseases in which amyloids are involved. 


Publications


Oral Presentations and Posters

Academic Awards