Lab Members‎ > ‎

Bikash Ranjan Sahoo

bsahoo@umich.edu  

Department of Chemistry and Biophysics
University of Michigan 
930 North University Avenue 
Ann Arbor, Michigan 48109-1055
Phone: (734) 647-6572

Education

Ph.D. (Biophysics)        Oct 2013 - Sep 2016  (Osaka University, Japan)

           

Positions

 Apr 2017 - Present       Postdoctoral fellow at University of Michigan, USA.

Oct 2016 - Mar 2017     Research Scientist at RIKEN Brain Science Institute, Japan.

Aug 2010 - Mar 2013     Senior Reseach Fellow, NAIP, ICAR, India.

Research interest

            Protein misfolding and aggregation into amyloid fibers happens during ageing and cause diseases like Alzheimer's (AD), Parkinson's ( PD ) and Type 2 Diabetes ( T2D ). Among numerous intrinsic and     extrinsic   factors   that   modulates   the   protein     aggregation,   cell-membrane   is    strongly   associated   with     the   pathogenesis of these   diseases.   We  therefore   would   like to  explore  the   molecular mechanism  of  such aggregation  at   atomistic scale   using   lipid-nanodiscs that provides  a  native    membrane-mimetic   model environment.   We are   integrating a     variety  of   advanced  biophysical  and   computational approaches to track the dynamic structural changes of two major amyloidogenic   peptides  amyloid-beta   ( Aβ )   and   Islet  amyloid   polypeptide  ( IAPP ) that  are connected to  AD and  T2D, respectively.   The  research findings and the high-resolution structure elucidation will be greatly  helpful to develop therapeutic strategies not only for AD and T2D, but also for several devastating neurodegenerative diseases in which amyloids are involved.

Publications

 (Selected)

C Barnaba, B R Sahoo, T Ravula, I M Meza, S C Im, G Anantharamaiah, L Waskell, A Ramamoorthy: Cytochrome-P450 induced ordering of microsomal membranes modulates affinity for drugs. Angewandte Chemie (2018) 57:3391 -3395 

K Yasuhara, J Arakida, T Ravula, S K Ramadugu, B R Sahoo, J I Kikuchi, A Ramamoorthy: Spontaneous lipid nanodisc fomation by amphiphilic polymethacrylate copolymers. Journal of the American Chemical Society (2017) 139:18657-18663 Link

B R Sahoo, K Maruyama, J R Edula, T Tougan, Y Lin, Y H Lee, T Horii and T Fujiwara: Bioengineered bovine Cathelicidin-5 with enhanced anticancer and antimicrobial activity. Scientific Reports (2017) 7:44781.



B R Sahoo, J Maharana, M C Patra, G K Bhoi, S K Lenka, P K Dubey, S Goyal, B Dehury, S K Pradhan: Structural and dynamic investigation of bovine folate receptor alpha (FOLR1), and role ofultra-high temperature processing on conformational and thermodynamic characteristics of FOLR1–folate complex. Colloids and surfaces B: Biointerfaces (2014); 121: 307-318.


B R Sahoo, J Maharana, G K Bhoi, S K Lenka, M C Patra, M R Dikhit, P K Dubey, S K Pradhan, B K Behera: A conformational analysis of mouse Nalp3 domain structures by molecular dynamics simulation, and binding sites analysis. Molecular BioSystems (2014); 10: 1104-1116.

B R Sahoo, M Basu, B Swain, J Maharana, M R Dikhit, P Jayasankar, M Samanta: Structural insights of rohu TLR3, its binding site analysis with fish reovirus dsRNA, polyI:C and zebrafish TRIF. International journal of biological macromolecules (2012); 51: 531-543.

 

Access to full-list of publications: http://www.researcherid.com/rid/H-7399-2012

Oral Presentations and Posters

Academic Awards