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Bikash Ranjan Sahoo  

Department of Chemistry and Biophysics
University of Michigan 
930 North University Avenue 
Ann Arbor, Michigan 48109-1055
Phone: (734) 647-6572


Ph.D. (Biophysics)        Oct 2013 - Sep 2016  (Osaka University, Japan)



 Apr 2017 - Present       Postdoctoral fellow at University of Michigan, USA.

Oct 2016 - Mar 2017     Research Scientist at RIKEN Brain Science Institute, Japan.

Aug 2010 - Mar 2013     Senior Reseach Fellow, NAIP, ICAR, India.

Research interest

            Protein misfolding and aggregation into amyloid fibers happens during ageing and cause diseases like Alzheimer's (AD), Parkinson's ( PD ) and Type 2 Diabetes ( T2D ). Among numerous intrinsic and     extrinsic   factors   that   modulates   the   protein     aggregation,   cell-membrane   is    strongly   associated   with     the   pathogenesis of these   diseases.   We  therefore   would   like to  explore  the   molecular mechanism  of  such aggregation  at   atomistic scale   using   lipid-nanodiscs that provides  a  native    membrane-mimetic   model environment.   We are   integrating a     variety  of   advanced  biophysical  and   computational approaches to track the dynamic structural changes of two major amyloidogenic   peptides  amyloid-beta   ( Aβ )   and   Islet  amyloid   polypeptide  ( IAPP ) that  are connected to  AD and  T2D, respectively.   The  research findings and the high-resolution structure elucidation will be greatly  helpful to develop therapeutic strategies not only for AD and T2D, but also for several devastating neurodegenerative diseases in which amyloids are involved.



C Barnaba, B R Sahoo, T Ravula, I M Meza, S C Im, G Anantharamaiah, L Waskell, A Ramamoorthy: Cytochrome-P450 induced ordering of microsomal membranes modulates affinity for drugs. Angewandte Chemie (2018) 57:3391 -3395 

K Yasuhara, J Arakida, T Ravula, S K Ramadugu, B R Sahoo, J I Kikuchi, A Ramamoorthy: Spontaneous lipid nanodisc fomation by amphiphilic polymethacrylate copolymers. Journal of the American Chemical Society (2017) 139:18657-18663 Link

B R Sahoo, K Maruyama, J R Edula, T Tougan, Y Lin, Y H Lee, T Horii and T Fujiwara: Bioengineered bovine Cathelicidin-5 with enhanced anticancer and antimicrobial activity. Scientific Reports (2017) 7:44781.

B R Sahoo, J Maharana, M C Patra, G K Bhoi, S K Lenka, P K Dubey, S Goyal, B Dehury, S K Pradhan: Structural and dynamic investigation of bovine folate receptor alpha (FOLR1), and role ofultra-high temperature processing on conformational and thermodynamic characteristics of FOLR1–folate complex. Colloids and surfaces B: Biointerfaces (2014); 121: 307-318.

B R Sahoo, J Maharana, G K Bhoi, S K Lenka, M C Patra, M R Dikhit, P K Dubey, S K Pradhan, B K Behera: A conformational analysis of mouse Nalp3 domain structures by molecular dynamics simulation, and binding sites analysis. Molecular BioSystems (2014); 10: 1104-1116.

B R Sahoo, M Basu, B Swain, J Maharana, M R Dikhit, P Jayasankar, M Samanta: Structural insights of rohu TLR3, its binding site analysis with fish reovirus dsRNA, polyI:C and zebrafish TRIF. International journal of biological macromolecules (2012); 51: 531-543.


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Oral Presentations and Posters

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