Kamgar-Parsi K., Tolchard J., Habenstein B., Loquet A., Naito A., Ramamoorthy A. Structural Biology of Calcitonin: From Aqueous Therapeutic Properties to Amyloid Aggregation. Isr. J. Chemistry. (In press) Link

Lee H. J., Korshavn K., Nam Y., Kang J., Paul T., Kerr R., Yoon I. S., Ozbil M., Kim K. S., Ruotolo B., Prabhakar R., Ramamoorthy A., Lim M. H. Structural and Mechanistic Insights into Development of Chemical Tools to Control Individual and Inter-related Pathological Features in Alzheimer's Disease. Chemistry  (2016). Link

Kang J., Lee S. J., Nam J.S., Lee H. J., Kang M. G., Korshavn K. J., Kim H. T., Cho J., Ramamoorthy A., Rhee H. W., Kwon T. H., Lim M. H. An Iridium (III) Complex as a Photoactivatable Tool for Oxidation of Amyloidgenic Peptides with Subsequent Modulation of Peptide Aggregation. Chemistry (2016). Link

Datta A., Yadav V., Ghosh A., Choi J., Bhattacharyya D., Kar R. K., Ilyas H., Dutta A., An E., Mukhopadhyay J., Lee D., Sanyal K., Ramamoorthy A., Bhunia A. Mode of Action of a Designed Antimicrobial Peptide: High Potency against Cryptococcus neoformans. Biophys. J. (2016) 111(8):1724-1737. Link

Sciacca M. F. M., Lolicato F., Di Mauro G., Milardi D., D'Urso L., Satriano C., Ramamoorthy A., La Rosa C. The Role of Cholesterol in Driving IAPP-Membrane Interactions, Biophys J. (2016) Link

Zhang R., Chen Y., Rodriguez-Hornedo N., Ramamoorthy A. Enhancing NMR Sensitivity of Natural-Abundance Low-Gamma Nuclei by Ultrafast Magic-Angle-Spinning Solid-State NMR Spectroscopy. Phys. Chem. Phys. Chem. (2016) Link

Bera S., Korshavn K. J., Kar R. K, Lim M. H., Ramamoorthy A., Bhunia A. Biophysical insights into the membrane interaction of the core amyloid-forming AB40 fragment K16-K28 and its role in the pathogenesis of Alzheimer's disease. Phys. Chem. Chem. Phys. (2016) Link

Jones M. R., Dyrager C., Hoarau M., Korshavn K. J., Lim M. H., Ramamoorthy A., Storr T. Multifunctional Quinoline-triazole Derivatives as Potential Modulators of Amyloid-B Peptide Aggregation. J. Inorg. Biochem. (2016) Link

Derrick J. S., Kerr R.A., Korshavn K. J., McLane M. J., Kang J., Nam E., Ramamoorthy A., Ruotolo B. T., Lim M. H. Importance of the Dimethylamino Functionality on a Multifunctional Framework for Regulating Metals, Amyloid-B, and Oxidative Stress in Alzheimer's Disease. Inorg. Chem. (2016)  Link

Fichman G., Guterman T., Damron J., Adler-Abramovich L., Schmidt J., Kesselman E., Shimon L.J., Ramamoorthy A., Talmon Y., Gazit E. Spontaneous Structural Transition and Crystal Formation in Minimal Supramolecular Polymer Model. Sci. Adv. (2016) 12;2(2) Link

Zhang R., Mroue K., Ramamoorthy A. Hybridizing Cross-Polarization with NOE or Refocused-INEPT Enhances the Sensitivity of MAS NMR Spectroscopy. J. Magn. Reson. (2016) (In press)

Zhang M., Huang R., Ackermann R., Im SC, Waskell L., Schwendeman A., Ramamoorthy A. Reconstitution of Cytb5-CytP450 Complex in Nanodiscs for Structural Studies by NMR. Angewandte Chemie. (2016) Link

Pandey M. K., Yarava J. R., Zhang R., Ramamoorthy A., Nishiyama Y. Proton-detected 3D 15N/1H/1H isotropic/anisotropic/isotropic chemical shift correlation solid-state NMR at 70 kHz MAS. Solid State Nuclear Magnetic Resonance. (In press)

Lee H. J., Kerr, R. A., Korshavn, K. J., Lee J., Kang J., Ramamoorthy A., Ruotolo B. T., Lim M. Effects of Hydroxyl Group Variations on a Flavonoid Backbone Toward Modulation of Metal-Free and Metal-Induced Amyloid-B Aggregation. Inorg. Chem. Front. (2016) Link

Zhang R., Ramamoorthy A. Constant-time 2D and 3D through-bond correlation NMR spectroscopy of solids under 60 KHz MAS. J. Chem. Phys. J. Chem. Phys. (2016) 144: 034202. Link


Pandey M. K., Zhang R., Hashi K., Ohki S., Nishijima G., Matsumoto S., Noguchi T., Deguchi K., Goto A., Shimizu T., Maeda H., Takahashi M., Yanagisawa Y., Yamazaki T., Iguchi S., Tanaka R., Nemoto T., Miyamoto T., Suematsu H., Saito K., Miki T., Ramamoorthy A., Nishiyama Y. 1020 MHz single-channel proton fast magic angle spinning solid-state NMR spectroscopy. J. Magn. Reson. (2015) 261:1-5. Link

Zhang R., Nishiyama Y., Ramamoorthy A. Proton-detected 3D (1)H/(13)C/(1)H correlation experiment for structural analysis in rigid solids under ultrafast-MAS above 60 kHz. J. Chem. Phys. (2015) 143(16):164201. Link

Zhang R., Mroue K. H., Ramamoorthy A. Proton chemical shift tensors determined by 3D ultrafast MAS double-quantum NMR spectroscopy. J. Chem. Phys. (2015) 143(14):144201. Link

Pithadia, A. S., Brender, J. R., Fierke, C. A., Ramamoorthy, A. Inhibition of IAPP Aggregation and Toxicity by Natural Products and Derivatives. J. Diabetes Res. (2015) Link

Pithadia, A. S., Bhunia, A., Sribalan, R., Padmini, V., Fierke, C. A., Ramamoorthy, A. Influence of a curcumin derivative on hIAPP aggregation in the absence and presence of lipid membranes. Chem. Comm. (2015) Link

Korshavn, K. J., Bhunia, A., Lim, M. H., Ramamoorthy, A. Amyloid-B Adopts a Conserved, Partially Folded Structure upon Binding to Zwitterionic Lipid Bilayers Prior to Amyloid Formation. Chem. Comm. (2015) Link

Korshavn, K. J., Jang, M., Kwak, Y. J., Kochi, A., Vertuani, S., Manfredini, S., Ramamoorthy, A., Lim, M. H. Reactivity of Metal-Free and Metal-Associated Amyloid-B with Glycosylated Polyphenols and Their Esterified Derivatives. Sci. Rep. (2015) Link

Derrick, J.S., Kerr, R., Nam, Y., Oh, S. B., Lee, H. J., Earnest, K. G., Suh, N., Peck, K. L., Ozbil, M., Korshavn, K. J., Ramamoorthy, A., Prabhakar, R., Merino, E. J., Shearer, J., Ruotolo, B., Lim, M. H. Covalent Link of a Redox-Active, Compact Molecule for the Crosslinking of Amyloidogenic Peptides into Nontoxic, Off-pathway Aggregates. J. Am. Chem. Soc. (2015) 137(46):14785-14797. Link

Zhang R, Ramamoorthy A. Dynamics-based selective 2D (1)H/(1)H chemical shift correlation spectroscopy under ultrafast MAS conditions. J Chem Phys. (2015) 142(20):204201.Link 

Jain N. S., Durr U. H. N., Ramamoorthy A. Bioanalytical methods for metabolomic profiling: Detection of head and neck cancer, including oral cancer. Chinese Chemical Letters. (2015) 26:407-415. Link

Zhang R, Ramamoorthy A. Selective excitation enables assignment of proton resonances and (1)H-(1)H distance measurement in ultrafast magic angle spinning solid state NMR spectroscopy. J Chem Phys. (2015) 143(3):034201. Link

Mroue KH, Nishiyama Y, Kumar Pandey M, Gong B, McNerny E, Kohn DH, Morris MD, Ramamoorthy A. Proton-Detected Solid-State NMR Spectroscopy of Bone with Ultrafast Magic Angle Spinning. Sci. Rep. (2015) 5:11991. Link

Datta A, Ghosh A, Airoldi C, Sperandeo P, Mroue KH, Jimenez-Barbero J, Kundu P, Ramamoorthy A, Bhunia A. Antimicrobial Peptides: Insights into Membrane Permeabilization, Lipopolysaccharide Fragmentation and Application in Plant Disease Control.
Sci. Rep. (2015) 5:11951. Link  

Kotler SA, Brender JR, Vivekanandan S, Suzuki Y, Yamamoto K, Monette M, Krishnamoorthy J, Walsh P, Cauble M, Holl MM, Marsh EN, Ramamoorthy A. High-resolution NMR characterization of low abundance oligomers of amyloid-beta without purification.
Sci. Rep. (2015) 5:11811. Link

Zhang R, Pandey MK, Nishiyama Y, Ramamoorthy A. A Novel High-Resolution and Sensitivity-Enhanced Three-Dimensional Solid-State NMR Experiment Under Ultrafast Magic Angle Spinning Conditions. Sci. Rep. (2015) 5:11810. Link

Kamarajan P, Hayami T, Matte B, Liu Y, Danciu T, Ramamoorthy A, Worden F, Kapila S, Kapila Y. Nisin ZP, a Bacteriocin and Food Preservative, Inhibits Head and Neck Cancer Tumorigenesis and Prolongs Survival. PLoS One. (2015) 10(7):e0131008. Link

Zhang M, Huang R, Im SC, Waskell L, Ramamoorthy A. Effects of membrane mimetics on cytochrome P450-cytochrome b5 interactions characterized by NMR spectroscopy. J. Biol. Chem. (2015) 290(20):12705-18. Link

Ghosh A, Pithadia AS, Bhat J, Bera S, Midya A, Fierke CA, Ramamoorthy A, Bhunia A. Self-assembly of a nine-residue amyloid-forming peptide fragment of SARS corona virus E-protein: mechanism of self aggregation and amyloid-inhibition of hIAPP. Biochemistry. (2015) 54(13):2249-61. Link

Brender JR, Krishnamoorthy J, Sciacca MF, Vivekanandan S, D'Urso L, Chen J, La Rosa C, Ramamoorthy A. Probing the sources of the apparent irreproducibility of amyloid formation: drastic changes in kinetics and a switch in mechanism due to micellelike oligomer formation at critical concentrations of IAPP. J Phys Chem B. (2015) 119: 2886-96. Link

Soblosky L, Ramamoorthy A, Chen Z. Membrane interaction of antimicrobial peptide using E.coli lipid extract as model bacterial cell membranes and SFG spectroscopy. Chem. Phys. Lipids. (in press) Link

Lee D, Bhunia A, Kotler SA, Ramamoorthy A. Detergent-type membrane fragmentation by MSI-78, MSI-367, MSI-594, and MSI-843 antimicrobial peptides, and inhibition by cholesterol: a solid-state NMR study. Biochemistry (in press) Link

Zhang M, Le Clair SV, Huang R, Ahuja S, Im SC, Waskell L, Ramamoorthy A. Insights into the role of substrates on the interaction between cytochrome b5 and cytochrome P450 2B4 by NMR. Sci. Rep. (Nature) (2015) 5:8392 Link

Zhang R, Nishiyama Y, Sun P, Ramamoorthy A, Phase cycling schemes for finite-pulse-RFDR MAS solid-state NMR experiments. J. Magn. Reson. 252 (2015): 55-66 Link 

Huang R, Zhang M, Rwere F, Waskell L, Ramamoorthy A. Kinetic and structural characterization of the intraction between the FMN binding domain of Cytochrome P450 reductase and cytochrome c. J. Biol. Chem. (in press) Link

Yamamoto K, Pearcy P, Lee D, Yu C, Im SC, Waskell L, Ramamoorthy A. Temperature-resistant bicelles for structural studies by solid-state NMR spectroscopy. Langmuir. 31 (2015): 1496-1504 Link

Chattah AK, Zhang R, Mroue KH, Pfund LY, Longhi MR, Ramamoorthy A. Investigating albendazole desmotropes by solid-state NMR spectroscopy. Mol Pharm (in press) Link

Zhang R., Damron J., Vosegaard T., Ramamoorhty A. A cross-polarization based rotating-frame separated-local-field NMR experiment under ultrafast MAS conditions. J. Magn. Reson. 250 (2015): 37-44 Link

Pandey M., Malon M., Ramamoorthy A., Nishiyama Y., Composite-180o pulse-based symmetry sequences to recouple proton Chemical Shift Anisotropy tensors under ultrafast MAS solid-state NMR spectroscopy. J. Magn. Reson. 250 (2015): 45-54 Link

Yamamoto K., Caporini MA., Im SC., Waskell L.,  Ramamoorthy A. Cellular solid-state NMR investigation of a membrane protein using dynamic nuclear polarization. Biochim Biophys Acta. 1848 (2015): 342-349 Link

Sudheendra US., Dhople V., Datta A., Kar RK., Shelburne CE., Bhunia A., Ramamoorthy A. Membrane disruptive antimicrobial activities of human β-defensin-3 analogs. Eur J Med Chem. 91 (2015): 91-99 Link


DeToma AS., Krishnamoorhty J., Nam YW., Lee HJ., Brender JR., Kochi A., Lee DK., Onnis V., Congiu C., Manfredini S., Vertuani S., Balboni G., Ramamoorthy A., Lim MH., Synthetic Flavonoids, Amonoisoflavones: interaction and reactivity with metal-free and metal-associated amyloid-β species. Chem Sci.  5 (2014): 4851-4862 Link

Mroue KH., Zhang R., Zhu P., McNerny E., Kohn DH., Morris MD., Ramamoorhty A., Acceleration of natural-abundance solid-state MAS NMR measurements on bone by paramagnetic relaxation from gadolinium-DTPA. J Magn Reson. 244 (2014): 90-97 Link

Yesuvadian R., Krishnamoorthy J., Ramamoorthy A., Bhunia A., Potent γ-seretase inhibitors/modulators interact with amyloid-β fibrils but do not inhibit fibrillation: a high-resolution NMR study. Biochem Biophy Res Commun. 477(4):590-595 Link

Patel H, Pithadia A., Brender J., Fierke C., Ramamoorthy A. In search of aggregation pathways of IAPP and other amyloidogenic proteins: finding answers through NMR spectroscopy. J. Phys. Chem. Lett. 5(11):1864-1870. Link

Zhang RC., Ramamoorthy A. Performance of RINEPT is amplified by dipolar couplings under ultrafast MAS conditions. J. Magn Reson. 243(2014):85-92 Link

Nishiyama Y., Malon M., Ishii Y., Ramamoorthy A. 3D 15N/15N/1H Chemical shift correlation experiments utilizing an RFDR-based 1H/1H mixing period at 100 kHz MAS. J. Magn Reson. 244(2014):1-5 Link

Huang R., Yamamoto K., Zhang M., Popovych N., Hung I., Im SC., Gan ZH., Waskell L., Ramamoorthy A., Probing the transmembrane structure and dynamics of microsomal cytochrome P450 reductase by solid-state NMR, Biophys. J.106(2014), 2126-2133. 

Nishiyama Y, Zhang R, Ramamoorthy A. Finite-pulse radio frequency driven recoupling with phase cycling for 2D 1H/1H correlation at ultrafast MAS frequencies. J. Magn Reson. 243(2014):25-32 Link

Pandey M, Vivekanandan S, Yamamoto K, Lm S C, Waskell L, Ramamoorthy A. Proton-detected 2D radio frequency driven recoupling solid-state NMR studies on micelle-associated cytochrome-b5. J. Magn. Reson. 242(2014):169-179 Link

Kotler SA, Walsh P, Breander JR, Ramamoorthy A. Differences between amyloid-beta aggregation in solution and on the membrane: Insights in to elucidation of the mechanistic details of Alzheimer's disease. Chem. Soc. Rev. (In press). Link

Yamamoto K, Paige P, Ramamoorthy A. Bicelles exhibiting magnetically-alignment for a broader range of temperatures - A solid state NMR study. Langmuir. 30(6):1622-1629 Link

Lee S, Zheng X, Krishnamoorthy J, Savelieff M, Park M, Brender JR, Kim H, Derrick S, Kochi A, Lee J, Kim C, Ramamoorthy A, Bowers T, Lim MH. Rational design of a structural framework with potential use to develop chemical reagents that target and modulate multiple facets of Alzheimer's disease. J. Am. Chem. Soc. 136(2014) 299-319. Link

Higashi K, Yamamoto K, Pandey M, Mroue K, Moribe K, Yamamoto K, Ramamoorthy A. Insights into atomic-level interaction between mefenamic acid and Eudragit EPO in a supersaturated solution by high-resolution magic-angle spinning NMR spectroscopy. Mol Pharm. 11(2014) 351-357. Link


Zhao J, Hu R, Sciacca MF, Brender JR, Chen H, Ramamoorthy A, Zheng J. Non-selective ion channel activity of polymorphic human islet amyloid polypeptide (amylin) double channels. Phys. Chem. Chem. Phys. (In press). Link

Tsukamoto M, Kuroda K, Ramamoorthy A, Yasuhara K. Modulation of raft domains in a lipid bilayer by boundary active curcumin. Chem. Comm. (In press). Link

Savelieff M, Liu Y, Senthamarai R, Korshavn K, Lee H, Ramamoorthy A, Lim MH, A small molecule that displays marked reactivity with copper-- versus zinc-amyloid-beta implicated in Alzheimer's disease. Chem. Comm. (In press). Link

Yamamoto K, Caporino M, Im SC, Waskell L, Ramamoorthy A. Shortening spin-lattice relaxation using a copper-chelated lipid at low-temperatures-- A magic angle spinning solid-state NMR study on a membrane-bound protein. J. Magn. Reson. 237(2013) 175-181. Link

Pandey M, Vivekanandan S, Ahuja S, Huang R, Im, SC, Waskell L and Ramamoorthy A. Cytochrome-P450-Cytochrome-b5 interaction in a membrane environment changes 15N chemical shift anisotropy tensors. J. Phys. Chem. B, 117(2013) 13851-13860. Link

Vivekanandan S, Ahuja S, Lm SC, Waskell L and Ramamoorthy A. 1H, 13C and 15N resonance assignments for the full-length mammalian cytochrome b5 in a membrane environment. Biomol. NMR Assigm. 7(2013). Link

Porcelli F, Ramamoorthy A, Barany G and Veglia G. On the role of NMR spectroscopy for characterization of Antimicrobial peptides. Membrane Proteins:Methods in Molecular Biology. 1063(2013) 159-180. Link

Yamamoto K, Gildenberg M, Ahuja S, Im SC, Pearcy P, Waskell L, Ramamoorthy A. Probing the transmembrane structure and topology of microsomal cytochrome p450 by solid-state NMR on temperature resistant bicelles. Scientific Reports (Nature) 3:2556. Link

Ramamoorthy A. Insights into protein misfolding and amyloidogenesis. Phys. Chem. Chem. Phys. 15(2013) 8867-8867. Link

Ramamoorthy A and Lim MH. Structural characterization and inhibition of toxic amyloid-beta oligomeric intermediates. Biophys J. 105(2013) 287-288. Link

Chatta AK, Mroue KH, Pfund LY, Ramamoorthy A, Longhi MR and Garnero C. Insights into novel supramolecular complexes of two solid forms of norfloxacin and beta-cylcodextrin. J. Pharm. Sci. (2013) Link

McElderry JP, Zhu P, Mroue KH, Xu J, Pavan B, Fang M, Zhao G, McNerny E, Kohn DH, Franceschi RT, Banaszak-Holl MM, Tecklenberg MMJ, Ramamoorthy A and Morris MD. Crystallinity and compositional changes in carbonated apatite. Evidence from 31P solid state NMR, Raman and AFM analysis. J Solid State Chem. 206 (2013) 192-198. Link

Yamamoto K, Durr UHN, Xu J, Lm SC, Waskell L and Ramamoorthy A. Dynamic interaction between membrane bound full length cytochrome p450 and b5 observed by solid-state NMR spectroscopy. Scientific Reports (Nature) 3:2538. Link

Tripathi P, Somashekar BS, Ponnusamy M, Gursky A, Dailey S, Kunju P, Lee CT, Chinnaiyan AM, Rajendiran TM and Ramamoorthy A. HR-MAS NMR tissue metabolomic signatures cross-validated by mass spectrometry distinguish bladder cancer from benign disease. J Proteome Res. 12(2013) 3519-3528. Link

Ahuja S, Jahr N, Im SC, Vivekanandan S, Popovych N, Le Clair S, Huang R, Soong R, Xu J, Yamamoto K, Nanga RPR, Bridges A, Waskell L and Ramamoorthy A. A model of the membrane-bound cytochrome b5-cytochrome P450 complex from NMR and mutagenesis data. J. Biol. Chem. 288(2013) 22080-22095. Link

Ramamoorthy A and Xu J. 2D 1H/1H RFDR and NOESY NMR Experiments on a Membrane-Bound Antimicrobial Peptide Under Magic Angle Spinning. J. Phys. Chem. B. 117(2013) 6693-7000. Link

Ding B, Soblosky L, Nguyen K, Geng J, Yu X, Ramamoorthy A, Chen Z. Physiologically-relevant modes of membrane interactions by the human antimicrobial peptide, LL-37, revealed by SFG experiments. Sci. Rep. 3(2013) 1-8. Link

Lee DK, Brender JR, Sciacca MF, Krishnamoorthy J, Yu C, Ramamoorthy A. Lipid composition dependent membrane fragmentation and pore-forming mechanisms of membrane disruption by pexiganan (MSI-78). Biochemistry. 52(2013) 3254-3263. Link

Suzuki Y, Brender JR, Soper MT, Krishnamoorthy J, Zhou Y, Ruotolo BT, Kotov NA, Ramamoorthy A, Marsh EN. Resolution of oligomeric species during the aggregation of Abeta1-40 using 19F NMR, Biochemistry. 52(2013) 1903-1912. Link 

Brender JR, Heyl DL, Samisetti S, Kotler SA, Osborne JM, Pesaru RR, Ramamoorthy A. Membrane disordering is not sufficient for membrane permeabilization by islet amyloidogenic polypeptide: studies of IAPP(20-29) fragments. Phys. Chem. Chem. Phys. 15(2013) 8908-8915. Link 

Brender JR, Krishnamoorthy J, Messina GML, Deb A, Vivekanandan S, LaRosa C, Penner-Hahn JE, Ramamoorthy A. Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide. Chem. Comm. 49(2013), 3339-3341. Link

Hyung SJ, DeToma AS, Brender JR, Lee S, Vivekanandan S, Kochi A, Choi J, Ramamoorthy A, Ruotolo BT, Lim MH. Insights into antiamyloidogenic properties of the green tea extract(-)-epigallocatechin-3-gallate toward metal-associated amyloid-beta species. Proc. Natl. Acad. Sci. U S A. (In press). Link

Dürr UHN, Soong R, Ramamoorthy A.When the detergent meets bilayer: Birth and coming of age of lipid bicelles. Prog. NMR Spec. 69(2013) 1-22. Link 

Sciacca MF, Milardi D, Messina GM, Marletta G, Brender JR,  Ramamoorthy A, La Rosa C. Cations as switches of amyloid-mediated membrane disruption mechanisms: Calcium and IAPP. Biophys. J. 104(2013) 173-184. Link

Hartman K, Brender JR, Monde K, Ono A, Evans ML, Popovych N, Chapman MR, Ramamoorthy A. Bacterial curli protein promotes the conversion of PAP(248-286) into the amyloid SEVI: cross-seeding of dissimiliar amyloid sequences. Peer J. (2013) DOI:10.7717/peerj.5. Link 

Pandey M, Ramamoorthy A. Quantum chemical calculation of amide-15N chemical shift anisotropy tensors for a membrane-bound cytochrome b5. J. Phys. Chem. B. 117(2013) 859-867. Link

Mackinnon N, Somashekar BS, Tripathi P, Ge W, Rajendiran TM, Chinnaiyan AM, Ramamoorthy A. MetaboID: A graphical user interface package for assignment of 1H NMR spectra of bodyfluids and tissues. J. Magn. Reson. 226(2013) 93-99. Link


Krishnamoorthy J, Brender JR, Vivekanandan S, Jahr N, Ramamoorthy A. Side chain dynamics reveals transient association of Ab(1-40) monomers with amyloid fibers. J. Phys. Chem. B.116(2012) 13618-13623. Link 

Somashekar BS, Amin AG, Tripathi P, Mackinnon N, Rithner CD, Shanley CA, Basaraba R, Henao-Tamayo M, Kato-Maeda M, Ramamoorthy A, Orme IM, Ordway DJ, Chatterijee D. J. Proteome. Res. 11(2012) 4873-4884. Link  

Zhu J, Andres CM, Xu J, Ramamoorthy A, Tsotsis T, Kotov NA. Pseudonegative thermal expansion and state of water in graphene oxide layered assemblies. ACS Nano 6(2012) 8357-8365. Link 

Sciacca MF, Brender JR, Lee DK, Ramamoorthy A. Phosphatidylethanolamine enhances amyloid fiber-dependent membrane fragmentation. Biochemistry 51(2012) 7676-7684. Link 

Mroue KH, MacKinnon N, Xu J, Zhu P, McNerny E, Kohn DH, Morris MD, Ramamoorthy A. High-resolution structural insights into bone: a solid-state NMR relaxation study utilizing paramagnetic doping. J. Phys. Chem. B 116(2012) 11656-11661.Link

Suzuki Y, Brender JR, Hartman K, Ramamoorthy A, Marsh EN. Alternative pathways of human islet amyloid polypeptide aggregation distinguished by 19F NMR-detected kinetics of monomer consumption. Biochemistry. 51(2012) 8154-8162. Link

Dürr UHN, Gildenberg M, Ramamoorthy A. The magic of bicelles lights up membrane protein structure. Chem. Rev. 112 (2012) 6054-6074. Link

McHenry AJ, Sciacca MF, Brender JR, Ramamoorthy A. Does cholesterol suppress the antimicrobial peptide induced disruption of lipid raft containing membranes?  Biochim. Biophys. Acta, Biomembr. 1818 (2012) 3019-3024. Link 

Jones MR, Service EL, Thompson JR, Wang MCP, Kimsey IJ, DeToma AS, Ramamoorthy A, Lim MH, Storr T. Dual-function triazole-pyridine derivatives as inhibitors of metal-induced amyloid-beta aggregation. Metallomics 4 (2012) 910-920. Link

Tripathi P, Kamarajan P, Somashekar BS, MacKinnon N, Chinnaiyan AM, Kapila YL, Rajendiran TM, Ramamoorthy A. Delineating Metabolic Signatures of Head and Neck Squamous Cell Carcinoma: Phospholipase A2, a Potential Therapeutc Target. Int. J. Biochem. Cell Biol. 44 (2012) 1852-1861. Link

Sciacca MFM, Kotler SA, Brender JR, Chen J, Lee DK, Ramamoorthy A. Two step mechanism of membrane disruption by Aβ through membrane fragmentation and pore formation. Biophys. J. 103 (2012) 702-710. Link

Brender JR, McHenry AJ, Ramamoorthy A. Does cholesterol play a role in the bacterial selectivity of antimicrobial peptides? Front. Immunol. 3 (2012) 1-4. Link

Pandey M, Vivekanandan S, Ahuja S, Kumar P, Waskell L, Im S-C, Ramamoorthy A. Determination of 15N Chemical Shift Anisotropy from a Membrane Bound Protein by NMR Spectroscopy. J. Phys. Chem. B 116 (2012) 7181-7189. Link

MacKinnon N, Ge W, Khan A, Somashekar B, Tripathi P, Siddiqui J, Wei J, Chinnaiyan A, Rajendira T, Ramamoorthy A. Variable Reference Alignment: an improved peak alignment protocol for NMR spectral data with large intersample variation. Anal. Chem. 84 (2012) 5372-5379. Link

Khitrin A, Xu J, Ramamoorthy A. Coherent averaging in the frequency domain. J. Chem. Phys. 136 (2012) 214504. Link

MacKinnon N, Khan AP, Chinnaiyan AM, Rajendiran TM, and Ramamoorthy A. Androgen receptor activation results in metabolite signatures of an aggressive prostate cancer phenotype: an NMR-based metabonomics study. Metabolomics 8(2012) 1026-1036. Link

Popovych N, Brender JR, Soong R, Vivekanandan S, Hartman K, Basrur V, MacDonald PM, Ramamoorthy A. Site specific interaction of the polyphenol EGCG with the SEVI amyloid peptide PAP(248-286). J. Phys. Chem. B 116 (2012) 3650-3658. Link

Brender J, Salamekh S, Ramamoorthy A. Membrane-disruption and early events in the aggregation of the diabetes related peptide IAPP from a molecular perspective. Acc. Chem. Res. 116 (2012) 3650–3658. Link

Huang R, Vivekanandan S, Brender JR, Abe Y, Naito A, Ramamoorthy A. NMR Characterization of monomeric and oligomeric conformations of human calcitonin and its interaction with EGCG. J. Mol. Biol. 416 (2012) 108-120. Link

Detoma AS, Salamekh S, Ramamoorthy A, Lim MH. Misfolded proteins in Alzheimer's disease and type II diabetes. Chem. Soc. Rev. 41 (2012) 608-621. Link


Moon JY, Kang Do, Cho YK, Kong KH, Lee DK, Ramamoorthy A. Characterization of factors favoring the recombinant expression and purification of LL-37 from Escherichia coli. J. Korean Soc. Appl. Biol. Chem. 54 (2011) 871-880. Link

Tomonaga Y, Hidaka T, Kawamura I, Nishio T, Ohsawa K, Okitsu T, Wada A, Sudo Y, Kamo N, Ramamoorthy A, Naito A. An Active Photoreceptor Intermediate Revealed by In Situ Photoirradiated Solid-State NMR Spectroscopy. Biophys. J. 101 (2011) L50-L52. Link

Braymer J, Choi J-S, DeToma A, Wang C, Nam K, Kampf J, Ramamoorthy A, Lim MH. Development of Bifunctional Stillbene Derivatives for Targeting and Modulating Metal-Amyloid-beta Species. Inorg. Chem. 50 (2011) 10724-10734. Link

Yamamoto K, Vivekanandan S, Ramamoorthy A. Fast NMR Data Acquisition From Bicelles Containing a Membrane-Associated Peptide at Natural-Abundance. J. Phys. Chem. B. 115 (2011) 12448-12455. Link

Somashekar B, Kamarajan P, Danciu T, Kapila Y, Chinnaiyan A, Rajendiran T, Ramamoorthy A. Magic Angle Spinning NMR Based Metabolic Profiling of Head and Neck Squamous Cell Carcinoma Tissues. J. Proteome R. 10 (2011) 5232-5241. Link

Khitrin A, Xu J, Ramamoorthy A. Cross-Correlations Between Low-gamma Nuclei in Solids Via a Common Dipolar Bath. J. Magn. Reson. 212 (2011) 95-101. Link

Nanga RPR, Brender JR, Vivekanandan S, Ramamoorthy A. Structure and Membrane Orientation of IAPP in its Natively Amidated Form at Physiological pH in a Membrane Environment. Biochim. Biophys. Acta, Biomembr. 10 (2011) 2337-2342. Link

Xu JD, Zhu PZ, Morris MD, Ramamoorthy A. Solid-State NMR Spectroscopy Provides Atomic-Level Insights Into the Dehydration of Cartilage. J. Phys. Chem. B. 115 (2011) 9948-9954. Link

Vivekanandan S, Brender JR, Lee SY, Ramamoorthy A. A Partially Folded Structure of Amyloid-Beta(1-40) in an Aqueous Environment. Biochem. Biophys. Res. Commun. 411 (2011) 312-316. Link

Salamekh S, Brender JR, Hyung S-J, Nanga RP, Vivekanandan S, Ruotolo BT, Ramamoorthy A. A Two Site Mechanism for the Inhibition of IAPP Amyloidogenesis by Zinc. J. Mol. Biol. 410 (2011) 294-306. Link

Yang P, Ramamoorthy A, Chen Z. Membrane Orientation of MSI-78 Measured by Sum Frequency Generation Vibrational Spectroscopy. Langmuir 27 (2011) 7760-7767. Link

Yoo S II, Yang M, Brender JR, Vivekanandan S, Sun K, Joo NE, Jeong S-H, Ramamoorthy A, and Kotov NA. Inhibition of Amyloid Peptide Fibrillation by Inorganic Nanoparticles: Functional Similarities with Proteins. Angew. Chem. Int. Ed. 50 (2011) 1-7. Link

Xu J, Smith PES, Soong R, Ramamoorthy A. A Proton Diffusion Based Solid-State NMR Approach for Structural Studies on Aligned Samples. J. Phys. Chem. B. 115 (2011) 4863-4871. Link

Brender JR, Lee EL, Hartman K, Wong PT, Ramamoorthy A, Steel DG, Gafni A. Biphasic effects of insulin on islet amyloid polypeptide membrane disruption. Biophys. J. 100 (2011) 685-692. Link

Brender JR, Nanga RP, Popovych N, Soong R, Macdonald PM, Ramamoorthy A. The amyloidogenic SEVI precursor, PAP248-286, is highly unfolded in solution despite an underlying helical tendency. Biochim. Biophys. Acta, Biomembr. 1808 (2011) 1161-1169. Link

Zimmerman LB, Worley BV, Palermo EF, Brender JR, Lee KD, Kuroda K, Ramamoorthy A, Meyerhoff ME. Absorbance-based assay for membrane disruption by antimicrobial peptides and synthetic copolymers using pyrroloquinoline quinone-loaded liposomes. Anal. Biochem. 411 (2011) 194-199. Link

Palermo E, Lee D-K, Ramamoorthy A, Kuroda K. The Role of Cationic Group Structure in Membrane Binding and Disruption by Amphiphilic Copolymers. J. Phys. Chem. B. 115 (2011) 366-375. Link

Lutker KM, Quiñones R, Xu J, Ramamoorthy A, Matzger AJ. Polymorphs and  hydrates of acyclovir. J. Pharm. Sci. 100 (2011) 949-963. Link


Domadia PN, Bhunia A, Ramamoorthy A, Bhattacharjya S. Structure, Interactions, and Antibacterial Activities of MSI-594 Derived Mutant Peptide MSI-594F5A in Lipopolysaccharide Micelles: Role of the Helical Hairpin Conformation in Outer-Membrane Permeabilization. J. Am. Chem. Soc. 132 (2010) 18417-18428. Link

Choi J-S, Braymer JJ, Nanga RPR, Ramamoorthy A, Lim MH. Design of small molecules that target metal-Abeta species and regulate metal-induced Abeta aggregation and neurotoxicity. Proc. Natl. Acad. Sci. U S A.  107 (2010) 21990-21995. Link

Thennarasu S, Huang R, Lee D-K, Yang P, Maloy L, Chen Z, Ramamoorthy A. Limiting an Antimicrobial Peptide to the Lipid-Water Interface Enhances Its Bacterial Membrane Selectivity: A Case Study of MSI-367. Biochemistry. 49 (2010) 10595-10605. Link

Nguyen KT, Soong R, Im S-C, Waskell L, Ramamoorthy A, Chen Z. Probing the Spontaneous Membrane Insertion of a Tail-Anchored Membrane Protein by Sum Frequency Generation. J. Am. Chem. Soc. 132 (2010) 15112-15115. Link

Xu J, Zhu P, Gan Z, Sahar N, Tecklenburg M, Morris MD, Kohn DH, Ramamoorthy A. Natural-Abundance 43Ca Solid-State NMR Spectroscopy of Bone. J. Am. Chem. Soc. 132 (2010) 11504-11509. Link

Xu J, Soong R, Im SC, Waskell L, Ramamoorthy A. INEPT-Based Separated-Local-Field NMR Spectroscopy: A Unique Approach to Elucidate Side-Chain Dynamics of Membrane-Associated Proteins. J. Am. Chem. Soc. 132 (2010) 9944-9947. Link

Brender JR, Hartman K, Nanga RPR, Popovych N, de la Salud Bea R, Vivekanandan S, Marsh ENG, Ramamoorthy A. Role of Zinc in Human Amyloid Polypeptide Aggregation. J. Am. Chem. Soc. 132 (2010) 8973-8983. Link

Saito H, Ando I, Ramamoorthy A. Chemical shift tensor - The heart of NMR: Insights into biological aspects of proteins. Prog. NMR Spec. 57 (2010) 181-228. Link

Epand RF, Maloy L, Ramamoorthy A, Epand RM. Amphipathic Helical Cationic Antimicrobial Peptides Promote Rapid Formation of Crystalline States in the Presence of Phosphatidylglycerol: Lipid Clustering in Anionic Membranes. Biophys. J. 98 (2010) 2564-2573. Link

Smith PES, Brender JR, Dürr UHN, Xu J, Mullen DG, Banaszack Holl MM, Ramamoorthy A. Solid-State NMR Reveals the Hydrophobic-Core Location of Poly(amidoamine) Dendrimers in Biomembranes. J. Am. Chem. Soc. 132 (2010) 8087-8097. Link

Yamamoto K, Xu J, Kawulka KE, Vederas JC, Ramamoorthy A. Use of a copper-chelated lipid speeds up NMR measurements from membrane proteins. J. Am. Chem. Soc. 132 (2010) 6929-6931. Link

Soong R, Smith PE, Xu J, Yamamoto K, Im SC, Waskell L, Ramamoorthy A. Proton-evolved local-field solid-state NMR studies of cytochrome b5 embedded in bicelles, revealing both structural and dynamical information. J. Am. Chem. Soc. 132 (2010) 5779-5788. Link

Epand RF, Maloy WL, Ramamoorthy A, Epand RM. Probing the "Charge Cluster Mechanism" in Amphipathic Helical Cationic Antimicrobial Peptides. Biochemistry 49 (2010) 4076-4084. Link

Bhunia A, Domadia PN, Hallock KJ, Ramamoorthy A, Bhattacharjya S. NMR Structure of Pardaxin, a Pore-Forming Antimicrobial Peptide, in Lipopolysaccharide Micelles: Mechanism of Outer membrane Permeabilization. J. Biol. Chem. 285 (2010) 3883-3895. Link

Veglia G and Ramamoorthy A. Preface: Special issue on "Membrane Protein Dynamics: Correlating Structure to Function" Biochim. Biophys. Acta, Biomembr. 1798 (2010) 65-67. Link

Ramamoorthy A, Lee D-K, Narasimhaswamy T, Nanga RPR. Cholesterol reduces pardaxin's dynamics-a barrel-stave mechanism of membrane disruption investigated by solid-state NMR. Biochim. Biophys. Acta, Biomembr. 1798 (2010) 223-227. Link

Io T, Fukami T, Yamamoto K, Suzuki T, Xu JD, Tomono K, Ramamoorthy A. Homogeneous Nanoparticles To Enhance the Efficiency of a Hydrophobic Drug, Antihyperlipidemic Probucol, Characterized by Solid-State NMR. Mol. Pharmaceutics 7 (2010) 299-305. Link

Thennarasu S, Tan AM, Penumatchu R, Shelburne CE, Heyl DL, Ramamoorthy A. Antimicrobial and Membrane Disrupting Activities of a Peptide Derived from the Human Cathelicidin Antimicrobial Peptide LL37. Biophys. J. 98 (2010) 248-257. Link


Nanga RPR, Brender JR, Vivekanandan S, Popovych N, Ramamoorthy A. NMR Structure in a Membrane Environment Reveals Putative Amyloidogenic Regions of the SEVI Precursor Peptide PAP(248-286). J. Am. Chem. Soc. 131 (2009) 17972-17979. Link

Zhu PZ, Xu JD, Sahar N, Morris MD, Kohn DH, Ramamoorthy A. Time-Resolved Dehydration-induced Structural Changes in an Intact Bovine Cortical Bone Revealed by Solid-State NMR Spectroscopy. J. Am. Chem. Soc. 131 (2009) 17064-17065. Link

Hindo SS, Mancino AM, Braymer JJ, Liu YH, Vivekanandan S, Ramamoorthy A, Lim MH. Small Molecule Modulators of Copper-Induced A beta Aggregation. J. Am. Chem. Soc. 131 (2009) 16663-16665. Link

Brender JR, Hartman K, Gottler LM, Cavitt ME, Youngstrom DW, Ramamoorthy A. Helical Conformation of the SEVI Precursor Peptide PAP(248-286), a Dramatic Enhancer of HIV Infectivity, Promotes Lipid Aggregation and Fusion. Biophys. J. 97 (2009) 2474-2483. Link

Bhattacharjya S, Ramamoorthy A. Multifunctional host defense peptides: functional and mechanistic insights from NMR structures of potent antimicrobial peptides. FEBS J. 276 (2009) 6465-6473. Link

Marsh ENG, Buer BC, Ramamoorthy A. Fluorine-a new element in the design of membrane-active peptides. Mol. BioSyst. 5 (2009) 1143-1147. Link

Gottler L and Ramamoorthy A. Membrane Orientation, Mechanism, and Function of Pexiganan - A Highly Potent Antimicrobial Peptide Designed From Magainin. Biochim. Biophys. Acta, Biomembr. 1788 (2009) 1680-1686. Link

Ramamoorthy A. Beyond NMR spectra of antimicrobial peptides: Dynamical images at atomic resolution and functional insights. Solid State Nucl. Magn. Reson. 35 (2009) 201-207. Link

Nanga RPR, Brender JR, Xu J, Hartman K, Vivekanandan S, Ramamoorthy A., Three-dimensional structure and orientation of rat islet amyloid polypeptide protein in a membrane environment by solution NMR spectroscopy. J. Am. Chem. Soc. 131 (2009) 8252-8261. Link

Yamamoto K, Soong R, Ramamoorthy A. Comprehensive Analysis of Lipid Dynamics Variation with Lipid Composition and Hydration of Bicelles Using Nuclear Magnetic Resonance (NMR) Spectroscopy. Langmuir 25 (2009) 7010-7018. Link

Soong R, Brender JR, MacDonald PM, Ramamoorthy A. Association of Highly Compact Type II Diabetes Related Islet Amyloid Polypeptide Intermediate Species at Physiological Temperature Revealed by Diffusion NMR Spectroscopy. J. Am. Chem. Soc. 131 (2009) 7079-7085. Link

Fukami T, Ishii T, Io T, Suzuki N, Suzuki T, Yamamoto K, Xu JD, Ramamoorthy A, Tomono K. Nanoparticle Processing in the Solid State Dramatically Increases the Cell Membrane Permeation of a Cholesterol-Lowering Drug, Probucol. Mol. Pharmaceutics 6 (2009) 1029-1035. Link

Barry J, Fritz M, Brender JR, Smith PES, Lee D-K, Ramamoorthy A, Determining the Effects of Lipophillic Drugs on Membrane Structure by Solid-State NMR Spectroscopy: The Case of the Antioxidant Curcumin. J. Am. Chem. Soc. 131 (2009) 4490-4498. Link

Smith PES, Brender JR, Ramamoorthy A. The Induction of Negative Curvature as a Mechanism of Cell Toxicity by Amyloidogenic Peptides: The Case of Islet Amyloid Polypeptide. J. Am. Chem. Soc. 131 (2009) 4470-4478. Link

Kandasamy SK, Lee D-K, Nanga RPR, Xu J, Santos JS, Larson R, Ramamoorthy A. Solid-state NMR and Molecular Dynamics Simulations Reveal the Oligomeric Ion-channels of TM2-GABAA Stabilized by Intermolecular Hydrogen Bonding. Biochim. Biophys. Acta, Biomembr. 1788 (2009) 686-695. Link

Fukuchi A, Ramamoorthy A, Takegoshi K. Efficient Cross-Polarization Using a Composite 0 degree Pulse for NMR Studies on Static Solids. J. Magn. Reson. 196 (2009) 105-109. Link

Bhunia A, Ramamoorthy A, Bhattacharjya S. Helical Hairpin Structure of a Potent Antimicrobial Peptide MSI-594 in Lipopolysaccharide Micelles by NMR Spectroscopy. Chem. Eur. J. 15 (2009) 2036-2040. Link


Nanga RPR, Brender JR, Xu J, Veglia G, Ramamoorthy A. Structures of Rat and Human Islet Amyloid Polypeptides in Membranes by NMR Spectroscopy and their Implications in Cell Toxicity. Biochemistry 47 (2008) 12689-12697. Link

Lee D-K, Kwon B-S, Ramamoorthy A. Freezing Point Depression in Water in Phospholipid Membranes - A Solid-State NMR Study. Langmuir 24 (2008) 13598-13604. Link

Brender JR, Hartman K, Reid K, Kennedy R, Ramamoorthy A. A Single Mutation in the Non-Amyloidogenic Region of IAPP Greatly Reduces Toxicity. Biochemistry 47 (2008) 12680-12688. Link

Dvinskikh SV, Yamamoto K, Scanu D, Deschenaux R, Ramamoorthy A. High-Resolution Characterization of Liquid-Crystalline [60]Fullerenes Using Solid-State Nuclear Magnetic Resonance Spectroscopy. J. Phys. Chem. B. 112 (2008) 12347-12353. Link

Xu J, Dürr UHN, Im SC, Gan Z, Waskell L, Ramamoorthy A. Bicelle-Enabled Structural Studies on Membrane Protein Cytochrome b5 by Solid-State MAS NMR Spectroscopy. Angew. Chem. Int. Ed. 47 (2008) 7864-7867. Link

Gottler LM, de la Salud Bea R, Shelburne CE, Ramamoorthy A, Marsh EN. Using Flourous Amino Acids to Probe the Effects of Changing Hydrophobicity on the Physical and Biological Properties of the Beta-Hairpin Antimicrobial Peptide Protegrin-1. Biochemistry. 47 (2008) 9243-9250. Link

Ramamoorthy A, Lee D-K, Santos JS, Henzler-Wildman KA. Nitrogen-14 Solid-State NMR Spectroscopy of Aligned Phospholipid Bilayers to Probe Peptide-Lipid Interaction and Oligomerization of Membrane Associated Peptides. J. Am. Chem. Soc. 130 (2008) 11023-11029. Link

Brender JR, Lee EL, Cavitt MA, Gafni A, Steel DG, Ramamoorthy A. Amyloid Fiber Formation and Membrane Disruption are Separate Processes Localized in Two Distinct Regions of IAPP, the Type-2-Diabetes-Related Peptide. J. Am. Chem. Soc. 130 (2008) 6424-6429. Link

Porcelli F, Verardi R, Shi L, Henzler-Wildman KA, Ramamoorthy A, Veglia G. NMR Structure of the Cathelicidin-Derived Human Antimicrobial Peptide LL-37 in Dodecylphosphocholine Micelles. Biochemistry 47 (2008) 5565-5572. Link

Gottler LM, Lee HY, Shelburne CE, Ramamoorthy A, Marsh ENG. Using Fluorous Amino Acids to Modulate the Biological Activity of an Antimicrobial Peptide. ChemBioChem 9 (2008) 370-373. Link

Hoskin DW, Ramamoorthy A. Studies on anticancer activities of antimicrobial peptides. Biochim. Biophys. Acta, Biomembr. 1778 (2008) 357-375. Link

Xu J, Struppe J, Ramamoorthy A. Two-dimensional homonuclear chemical shift correlation established by the cross-relaxation driven spin diffusion in solids. J. Chem. Phys. 128 (2008) 052308. Link


Dürr UHN, Waskell L, Ramamoorthy A. The cytochromes P450 and b5 and their reductases-Promising targets for structural studies by advanced solid-state NMR spectroscopy. Biochim. Biophys. Acta, Biomembr. 1768 (2007) 3235-3259. Link

Podsiadlo P, Kaushik AK, Arruda EM, Waas AM, Sup B, Shim, Xu J, Nandivada H, Pumplin BG, Lahann J, Ramamoorthy A, Kotov NA. Ultrastrong and Stiff Layered Polymer Nanocomposites. Science 318 (2007) 80-83. Link

Brender JR, Dürr UHN, Heyl D, Budarapu MB, Ramamoorthy A. Membrane Fragmentation by an Amyloidogenic Fragment of Human Islet Amyloid Polypeptide Detected by Solid-State NMR Spectroscopy of Membrane Nanotubes. Biochim. Biophys. Acta, Biomembr. 1768 (2007) 2026-2029. Link

Dürr UHN, Yamamoto K, Im SC, Waskell L, Ramamoorthy A. Solid-State NMR Reveals Structural and Dynamical Properties of a Membrane-Anchored Electron-Carrier Protein, Cytochrome b5. J. Am. Chem. Soc. 129 (2007) 6670-6671. Link

Textbook: A. Ramamoorthy (Ed.), Thermotropic Liquid Crystals: Recent Advances, Springer, Dordrecht, The Netherlands 2007.

Shelburne C, An F, Dhople V, Ramamoorthy A, Lopatin D, Lantz M. The spectrum of anti-microbial activity of the bacteriocin Subtilosin A. J. Antimicrob. Chemother. 59 (2007) 297-300. Link

Dvinskikh SV, Yamamoto K, Dürr UHN, Ramamoorthy A. Sensitivity and resolution enhancement in solid-state NMR spectroscopy of bicelles. J. Magn. Reson. 184 (2007) 228-235. Link

Dvinskikh SV, Dürr UHN, Yamamoto K, Ramamoorthy A. High-resolution 2D NMR spectroscopy of bicelles to measure the membrane interaction of ligands. J. Am. Chem. Soc. 129 (2007) 794-802. Link

Ramamoorthy A, Kandasamy SK, Lee D-K, Kidambi S, Larson RG. Structure, Topology and tilt of cell-signaling peptides containing nuclear localization sequences in membrane bilayers determined by solid-state NMR and molecular dynamics simulation studies. Biochemistry 46 (2007) 965-975. Link


Special issue: A. Ramamoorthy (Ed.). Membrane biophysics of antimicrobial peptides. Biochim. Biophys. Acta 1758 (2006) 1177-1540. Link

Dhople V, Krukemeyer A, Ramamoorthy A. The human beta-defensin-3, an antibacterial peptide with multiple biological functions. Biochim. Biophys. Acta, Biomembr. 1758 (2006) 1499-1512. Link

Dürr UHN, Sudheendra US, Ramamoorthy A. LL-37, the only human member of the cathelicidin family of antimicrobial peptides. Biochim. Biophys. Acta, Biomembr. 1758 (2006) 1408-1425. Link

Moon JY, Henzler-Wildman KA, Ramamoorthy A. Expression and purification of a recombinant LL-37 from Escherichia coli. Biochim. Biophys. Acta, Biomembr. 1758 (2006) 1351-1358. Link

Dvinskikh SV, Yamamoto K, Ramamoorthy A. Heteronuclear isotropic mixing separated local field NMR spectroscopy. J. Chem. Phys. 125 (2006) 034507. Link

Ramamoorthy A, Thennarasu S, Lee D-K, Tan A, Maloy L. Solid-State NMR investigation of the membrane-disrupting mechanism of antimicrobial peptides MSI-78 and MSI-594 derived from Magainin 2 and Melittin. Biophys. J. 91 (2006) 206-216. Link

Ramamoorthy A, Thennarasu S, Tan A, Gottipati K, Sreekumar S, Heyl DL, An FYP, Shelburne CE. Deletion of all cycteines in Tachyplesin I abolishes hemolytic activity and retains antimicrobial activity and LPS selective binding. Biochemistry 45 (2006) 6529-6540. Link

Dvinskikh SV, Dürr U, Yamamoto K, Ramamoorthy A. A high-resolution solid-state NMR approach for the structural studies of bicelles. J. Am. Chem. Soc. 128 (2006) 6326-7. Link

Porcelli F, Buck-Koehntop B, Thennarasu S, Ramamoorthy A, Veglia G. Structures of the dimeric and monomeric variants of magainin antimicrobial peptides (MSI-78 and MSI-594) in micelles and bilayers by NMR spectroscopy. Biochemistry 45 (2006) 5793-5799. Link

Yamamoto K, Dvinskikh SV, Ramamoorthy A. Measurement of heteronuclear dipolar couplings using a rotating frame solid-state NMR experiment. Chem. Phys. Lett. 419 (2006) 533-536. Link

Dvinskikh SV, Yamamoto K, Ramamoorthy A. Separated local field NMR spectroscopy by windowless isotropic mixing. Chem. Phys. Lett. 419 (2006) 168-173. Link

Textbook: A. Ramamoorthy (Ed.). NMR Spectroscopy of Biological Solids, Taylor & Francis, Ramamoorthy A, Thennarasu S, Tan A, Lee D-K, Clayberger C, Krensky AM, Cell selectivity correlates with membrane-specific interactions: A case study on the antimicrobial peptide G15 derived from granulysin, Biochim. Biophys. Acta, Biomembr. 1758 (2006) 154-163. Link

Saalwachter K, Ramamoorthy A, Sensitivity enhancement by inverse detection in solids, NMR Spectroscopy of Biological Solids, Taylor and Francis Group, New York (2006) 151-175.

Fujiwara T, Ramamoorthy A. How far can the sensitivity of NMR be increased? Ann. Rep. NMR Spectrosc. 58 (2006) 155-175.

Epand RF, Ramamoorthy A. Epand RM, Membrane lipid composition and the interaction of pardaxin: The role of cholesterol. Prot. Pept. Lett. 13 (2006) 1-5. Link


Mecke A, Lee D-K, Ramamoorthy A, Orr BG, Holl MMB. Membrane thinning due to antimicrobial peptide binding: An atomic force microscopy study of MSI-78 in lipid bilayers. Biophys. J. 99 (2005) 4043-4050. Link

Powers JPS, Tan A, Ramamoorthy A, Hancock REW. Solution structure and interaction of the antimicrobial polyphemusins with lipid membranes. Biochemistry 44 (2005) 15504-15513. Link

Narasimhaswamy T, Monette M, Lee D-K, Ramamoorthy A. Solid-state NMR characterization and determination of the orientational order of a nematogen. J. Phys. Chem. B 109 (2005) 19696-19703. Link

Thennarasu S, Lee D-K, Poon A, Kawulka KE, Vederas JC, Ramamoorthy A. Membrane permeabilization, orientation, and antimicrobial mechanism of subtilosin A. Chem. Phys. Lipids 137 (2005) 38-51. Link

Mecke A, Lee D-K, Ramamoorthy A, Orr BG, Holl MMB. Synthetic and natural polycationic polymer nanoparticles interact selectively with fluid-phase domains of DMPC lipid bilayers. Langmuir 21 (2005) 8588-8590. Link

Narasimhaswamy T, Lee D-K, Somanathan N, Ramamoorthy A. Solid-state NMR characterization of a novel thiophene-based three phenyl ring mesogen. Chem. Materials 17 (2005) 4567-4569. Link

Yamamoto K, Ermakov VL, Lee D-K, Ramamoorthy A. PITANSEMA-MAS, a solid-state NMR method to measure heteronuclear dipolar couplings under MAS. Chem. Phys. Lett. 408 (2005) 118-122. Link

Thennarasu S, Lee D-K, Tan A, Kari UP, Ramamoorthy A. Antimicrobial activity and membrane selective interactions of a synthetic lipopeptide MSI-843. Biochim. Biophys. Acta, Biomembr. 1711 (2005) 49-58. Link

Yamamoto K, Lee D-K, Ramamoorthy A. Broadband-PISEMA solid-state NMR spectroscopy. Chem. Phys. Lett. 407 (2005) 289-293. Link

Narasimhaswamy T, Lee D-K, Yamamoto K, Somanathan N, Ramamoorthy A. A 2D solid-state NMR experiment to resolve overlapping aromatic resonances of thiophene-based nematogens. J. Am. Chem. Soc. 127 (2005) 6958-6959. Link

Narasimhaswamy T, Somanathan N, Lee D-K, Ramamoorthy A. Synthesis and C-13 CPMAS NMR characterization of novel thiophene-based nematogens. Chem. Materials 17 (2005) 2013-2018. Link


Lee D-K, Narasimhaswamy T, Ramamoorthy A, PITANSEMA, a low-power PISEMA solid-state NMR experiment, Chem. Phys. Lett. 399 (2004) 359-362. Link

Pointer-Keenan CD, Lee D-K, Hallock K, Tan AM, Zand R, Ramamoorthy A. Investigation of the interaction of myelin basic protein with phospholipid bilayers using solid-state NMR spectroscopy. Chem. Phys. Lip. 132 (2004) 47-54. Link

Mecke A, Uppuluri S, Sassanella TM, Lee D-K, Ramamoorthy A, Baker JR, Orr BG, Holl MMB. Direct observation of lipid bilayer disruption by poly(amidoamine) dendrimers. Chem. Phys. Lip. 132 (2004) 3-14. Link

Porcelli F, Buck B, Lee D-K, Hallock KJ, Ramamoorthy A, Veglia G. Structure and orientation of pardaxin determined by NMR experiments in model membranes. J. Biol. Chem. 279 (2004) 45815-45823. Link

Poon A, Birn J, Ramamoorthy A. How does an amide-N-15 chemical shift tensor vary in peptides? J. Phys. Chem. B 108 (2004) 16577-16585. Link

Ramamoorthy A, Wei YF, Lee D-K. PISEMA solid-state NMR spectroscopy. Ann. Rep. NMR Spectrosc. 52 (2004) 1-52.

Bim J, Poon A, Mao Y, Ramamoorthy A. Ab initio study of C-13 alpha chemical shift anisotropy tensors in peptides. J. Am. Chem. Soc. 126 (2004) 8529-8534. Link

Henzler-Wildman KA, Martinez GV, Brown MF, Ramamoorthy A. Perturbation of the hydrophobic core of lipid bilayers by the human antimicrobial peptide LL-37. Biochemistry 43 (2004) 8459-8469. Link

Wildman KAH, Ramamoorthy A, Wakamiya T, Yoshikawa T, Crisma M, Toniolo C, Formaggio F. A study of a C-alpha,C-beta-didehydroalanine homo-oligopeptide series in the solid-state by C-13 cross-polarization magic angle spinning NMR. J. Pept. Sci. 10 (2004) 336-341. Link

Lee D-K, Wildman KH, Ramamoorthy A. Solid-state NMR spectroscopy of aligned lipid bilayers at low temperatures. J. Am. Chem. Soc. 126 (2004) 2318-2319. Link

Santos JS, Lee D-K, Ramamoorthy A. Effects of antidepressants on the conformation of phospholipid headgroups studied by solid- state NMR. Magn. Reson. Chem. 42 (2004) 105-114. Link


Kidambi S, Schurko RW, Hung I, Ramamoorthy A. Nuclear magnetic resonance studies of metals in solid state non-metallic materials. Mater. Sci. Tech. 19 (2003) 1191-1196. Link

Wildman KAH, Wilson EE, Lee D-K, Ramamoorthy A. Determination of the conformation and stability of simple homopolypeptides using solid-state NMR. Solid State Nucl. Magn. Reson. 24 (2003) 94-109. Link

Wildman KAH, Lee D-K, Ramamoorthy A. Mechanism of lipid bilayer disruption by the human antimicrobial peptide, LL-37. Biochemistry 42 (2003) 6545-6558. Link

Kidambi S, Lee D-K, Ramamoorthy A. Interaction of Cd and Zn with biologically important ligands characterized using solid-state NMR and ab initio calculations. Inorg. Chem. 42 (2003) 3142-3151. Link

Hallock KJ, Lee D-K, Ramamoorthy A. MSI-78, an analogue of the magainin antimicrobial peptides, disrupts lipid bilayer structure via positive curvature strain. Biophys. J. 84 (2003) 3052-3060. Link

Mascioni A, Porcelli F, Ilangovan U, Ramamoorthy A, Veglia G. Conformational preferences of the amylin nucleation site in SDS micelles: An NMR study. Biopolymers 69 (2003) 29-41. Link

Kidambi S, Lee D-K, Ramamoorthy A. Characterization of metal centers in bioinorganic complexes using ab initio calculations of Cd-113 chemical shifts. Inorg. Chem. 42 (2003) 2200-2202. Link


Kidambi S, Ramamoorthy A. Quantum chemical calculations of cadmium chemical shifts in inorganic complexes. J. Phys. Chem. A. 106 (2002) 10363-10369. Link

Wei Y, Lee D-K, McDermott AE, Ramamoorthy A. A 2D MAS solid-state NMR method to recover the amplified heteronuclear dipolar and chemical shift anisotropic interactions. J. Magn. Reson. 158 (2002) 23-35. Link

Henzler Wildman KA, Lee D-K, Ramamoorthy A. Determination of effect of a-helix and b-sheet stability in the solid-state: A solid-state NMR investigation of poly(L-alanine). Biopolymers 64 (2002) 246-254. Link

Hallock KJ, Lee D-K, Omnaas J, Mosberg HI, Ramamoorthy A. Membrane composition determines pardaxin's mechanism of lipid bilayer disruption. Biophys. J. 83 (2002) 1004-1013. Link

Shekar SC, Lee D-K, Ramamoorthy A. Chemical shift anisotropy and offset effects in cross polarization solid-state NMR spectroscopy. J. Magn. Reson. 157 (2002) 223-234. Link

Hallock KJ, Henzler Wildman KA, Lee D-K, Ramamoorthy A. An innovative procedure using a sublimable solids can be used to mechanically align lipid bilayers for solid-state NMR studies. Biophys. J. 82 (2002) 2499-2503. Link

Shekar SC, Ramamoorthy A, Wittebort RJ. Determination of the chemical shielding orientation from two or one of the three conventional rotations of a single crystal. J. Magn. Reson. 155 (2002) 257-262. Link

Taylor DM, Ramamoorthy A. Coherence transfer through homonuclear dipolar coupling in an unoriented two spin-1/2 solid-state system. J. Mol. Struct. 602-603 (2002) 115-124. Link

Wei YF, Lee D-K, Hallock KJ, Ramamoorthy A. One-dimensional 1H-detected solid-state NMR experiment to determine amide-1H chemical shifts in peptides. Chem. Phys. Lett. 351 (2002) 42-46. Link

Santos JS, Lee D-K, Hallock KJ, Ramamoorthy A. Cholesterol and antidepressant drug interactions with phospholipids - A solid-state NMR study, Recent Research Developments in Physical Chemistry, Transworld Research Network 6 (2002) 179-211.


Shekar SC, Lee D-K, Ramamoorthy A. An experimental strategy to dramatically reduce the RF power used in cross polarization solid-state NMR spectroscopy. J. Am. Chem. Soc. 123 (2001) 7467-7468. Link

Wei YF, Ramamoorthy A. 2D 15N-15N isotropic chemical shift correlation established by 1H-1H dipolar coherence transfer in biological solids. Chem. Phys. Lett. 342 (2001) 312-316. Link

Shekar SC, Ramamoorthy A. The unitary evolution operator for cross-polarization schemes in NMR. Chem. Phys. Lett. 342 (2001) 127-134. Link

Wei Y, Lee D-K, Ramamoorthy A. Solid-state 13C chemical shift anisotropy tensors of polypeptides. J. Am. Chem. Soc. 123 (2001) 6118-6126. Link

Wei Y, Lee D-K, Ramamoorthy A. A two-dimensional magic angle decoupling and magic angle turning solid-state NMR method - An application to study chemical shift tensors from peptides that are non-selectively labeled with 15N isotope. J. Phys. Chem. B 104 (2001) 4752-4762. Link

Brender JR, Taylor DM, Ramamoorthy A. Orientation of amide-nitrogen-15 chemical shift tensors in peptides: A quantum chemical study. J. Am. Chem. Soc. 123 (2001) 914-922. Link


Hallock KJ, Lee D-K, Ramamoorthy A. The effects of librations on the 13C chemical shift and 2H electric field gradient tensors in beta-calcium formate. J. Chem. Phys. 113 (2000) 11187-11193. Link

Wei YF, Lee D-K, Ramamoorthy A. One-dimensional dipolar-shift spectroscopy under magic angle spinning to determine the chemical-shift anisotropy tensors. Chem. Phys. Lett. 324 (2000) 20-24. Link

Stout KL, Hallock KJ, Kampf JW, Ramamoorthy A. N-Acetyl-L-phenylalanine. Acta Cryst. C56 (2000) e100. Link


Taylor DM, Ramamoorthy A. Analysis of dipolar-coupling mediated coherence transfer in a homonuclear two spin 1/2 solid-state system. J. Magn. Reson. 141 (1999) 18-28. Link

Ramamoorthy A, Wu CH, Opella SJ. Experimental aspects of multidimensional solid-state NMR correlation spectroscopy. J. Magn. Reson. 140 (1999) 131-140. Link

Lee D-K, Santos JS, Ramamoorthy A. Nitrogen-15 chemical shift anisotropy and 1H-15N dipolar coupling tensors associated with the phenylalanine residue in the solid-state. Chem. Phys. Lett. 309 (1999) 209-214. Link

Lee D-K, Santos JS, Ramamoorthy A. Application of one-dimensional dipolar-shift solid-state NMR spectroscopy to study the backbone conformation of membrane-associated peptides in phospholipid bilayers. J. Phys. Chem. B 103 (1999) 8383-8390. Link

Hallock KJ, Lee D-K, Ramamoorthy A. Carbon-13 chemical shifts and 1H-13C dipolar couplings in metal sandwich solids using one-dimensional solid-state NMR spectroscopy. Chem. Phys. Lett. 302 (1999) 175-180. Link

Lee D-K, Ramamoorthy A,Determination of the solid-state conformations of polyalanine using magic-angle spinning NMR spectroscopy. J. Phys. Chem. B 103 (1999) 271-275. Link