Biophysics 930 N. University Ave. Ann Arbor, MI 48109 (734) 763-9318

Academic Background

Ph.D. Chemistry, Washington State University, 2016

M.Sc. Food Science & Technology (cum laude), Università degli Studi di Parma (Italy), 2007

B.Sc. Food Science & Technology, Università degli Studi di Parma (Italy), 2005

Research project

Cytochrome P450 Protein/Protein and Protein/Lipids Interactions

Professional experiences

2011-2012: Assistant Professor (100% teaching duties), Dept. Chem Engineering, ITESO - Universidad Jesuita de Guadalajara, Mexico

2010-2011: Researcher (CONACyT Fellow), Dept. Biochem Engineering, Instituto Tecnologico de Veracruz, Mexico

2007-2008: Researcher, Dept. Industrial Engineering, Università degli Studi di Parma, Italy

Publications

(selected)

1. Barnaba C., Sahoo B.R., Ravula T., Medina-Meza I.G., Im S., Waskell L., Ramamoorthy A. (2018) Cytochrome-P450 Induced Ordering of Microsomal Membranes Modulates Affinity for Drugs, Angew Chem, 130 (13), 3449-3453
2. Barnaba C., Taylor E., Brozik J.A. (2017) Dissociation Constants of Cytochrome P450 2C9 / Cytochrome P450 Reductase Complexes in a Lipid Bilayer Membrane Depend on NADPH: A Single Protein Tracking Study, J Am Chem Soc, 139(49), 17923-17934.
3. Barnaba C., Gentry K., Sumangala N., Ramamoorthy, A. (2017) The Catalytic Function of Cytochrome P450 is Entwined with its Membrane-Bound Nature, F1000 Review, (Invited Review), 6, 662.
4. Barnaba C., Martinez M., Taylor E., Barden A.O., Brozik J.A. (2017) Single Protein Tracking Reveals that NADPH Mediates the Insertion of Cytochrome P450-Reductase into a Biomimetic of the Endoplasmic Reticulum, J Am Chem Soc, 139(15), 5420-5430.
5. Barnaba C., Rodríguez-Estrada M.T., Lercker G., García H.S., Medina-Meza I.G. (2016) Cholesterol photo-oxidation: a chemical reaction network for kinetic modeling, Steroids, 116, 52-59.
6. Barnaba C., Yadav J., Nagar S., Korzekwa K., Jones J.P. (2016) Mechanism-based inhibition of CYP3A4 by podophyllotoxin: the aging of an intermediate is important for in vitro-in vivo correlations, Molecular Pharmaceutics, 13(8), 2833-2843.
7. Barnaba C., Humphreys S.C., Barden A., Jones J.P., Brozik J.A. (2016) Substrate-dependent native luminescence of Cytochromes P450 2C9, 3A4 and P450cam, J Phys Chem B, 120(12), 3038-3047.

Conferences