Lab Members‎ > ‎

Janarthanan Krishnamoorthy

janar@umich.edu


Biophysics
930 N. University Ave.
Ann Arbor, MI, 48109

(734) 763-9318

Website

Current research

Structural misfolding of amyloid proteins, including A-beta and amylin.

Education

B.Pharmaceutical - Madras medical college

M.Tech ( Industrial biotechnology) - Anna university

Ph.D. (NMR chemical exchange) - National university of Singapore

Academics

Post-doctoral fellow: April 2011 - present
    PI: Ramamoorthy, University of Michigan

Post-doctoral fellow: January 2010 - April 2011
    PI: Smita Mohanty, Auburn University

Ph.D. research: August  2005 - January 2010
    PI: Henry Mok and Yang Daiwen, National University of Singapore

Publications

1) Janarthanan Krishnamoorthy, Victor C. K. Yu, Yu-Keung Mok. Auto-FACE: An NMR Based Binding Site Mapping Program for Fast Chemical Exchange Protein-Ligand Systems, February 18, 2010, PLoS ONE 5(2): e8943.

2) Janarthanan Krishnamoorthy, Smita Mohanty. OPEN-ITC: An alternate computational approach to analyze the ITC data of complex binding mechanisms, November 2011, Journal of Molecular Recognition 24(6):pg 1056-1066.

Poster and oral presentation

Title: A novel computational approach for analyzing the binding site of Bcl-2 family proteins using NMR spectroscopic data (poster)
    Venue and date: May 2008, Italy Ciocco.
    Chair persons: Rafael Bruschweiler, Stephan Grzeseik
    Organized by: Gordon conference

Title: Calculation of NMR relaxation parameters using Redfield-theory (Application in Protein-ligand interaction)
    Venue and date : December 2008, Singapore
    Chair persons: Steve Pascal
    Organized by:  13th Biological graduate Conference, NUS.

Book

1) Janarthanan Krishnamoorthy, Yu-Keung Mok. NMR chemical exchange in mapping the protein-ligand binding site,                    https://www.morebooks.de/store/gb/book/nmr-chemical-exchange-in-mapping-the-protein-ligand-binding-site/isbn/978-3-8443-9735-2, LAP LAMBERT Academic Publishing (2011-05-20)

Award

  • Best mentorship award - Singapore government (Nov 2005)
  • Astar assistanceship - Decoding Autodock4.2 to incorporate experimental constraint (Dec 2009 - Jan 2010)

Software developed

  • Auto-Face: Chemical shift analysis for fast exchange regimes
  • Auto-Mex: Transitional probability based line-shape analysis for all chemical exchange regimes
  • Open-ITC: ITC data analysis for complex binding mechanisms