Lab Members‎ > ‎

Katherine Gentry


Biophysics
930 N. University Ave.
Ann Arbor, MI 48109

(734) 763-9318

Academic Background

August 2014 - Present        PhD Candidate, Biophysics, University of Michigan, Ann Arbor
                                            Advisor: Professor A. Ramamoorthy

August 2010 - May 2014    Biochemistry and Chemistry, Kansas State University, Manhattan, KS
                                           Graduated Cum Laude

Research project

Cytochrome P450s are a ubiquitous family of enzymes that are responsible for catalyzing the first step in metabolism for many substrates, including over 70% of the drugs on the current market. I am studying the protein-protein interactions between cytochrome P450 and its two redox partners, cytochrome b5 and cytochrome P450 reductase with a variety of biochemical, biophysical, and NMR techniques. My projects include studying the role that membrane plays on this interaction as well as examining how substrates influence how these proteins interact. 

Publications
Gentry, K.A., Zhang, M., Im, S.C., Waskell, L., Ramamoorthy, A. Substrate Mediated Redox Partner Selectivity of Cytochrome P450. Chem. Comm. (Accepted) 


Prade, E., Mahajan, M., Im, S.C., Zhang, M., Gentry, K. A., Anantharamaiah, G. M., Waskell, L., Ramamoorthy, A. A Minimal Functional Complex of Cytochrome P450 and FBD of Cytochrome P450 Reductase in Nanodiscs. Angew. Chem. Int. Ed. Engl. 2018. 

Gentry K. A., Prade E., Barnaba C., Zhang M., Mahajan M., Im S.C., Anantharamaiah G. M., Nagao S., Waskell L., Ramamoorthy A.
Kinetic and Structural Characterization of the Effects of Membrane on the Complex of Cytochrome b5 and Cytochrome c.
 Scientific Reports7:7793 (2017). Link


Barnaba C., Gentry K. A., Sumangala N., Ramamoorthy A. The catalytic function of cytochrome P450 is entwined with its membrane-bound nature. F1000Res. 2017, 6:662.

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Lam HT, Graber MC, Gentry KA, Bieschke J. Stabilization of α-Synuclein Fibril Clusters Prevents Fragmentation and Reduces Seeding Activity and Toxicity. Biochemistry. 2016, 55, 675-85. Link



Conferences

Biophysical Society 2018 - San Francisco CA
Protein Society 2017 - Montreal, Quebec, Canada
Great Lakes Drug Metabolism and Deposition Group Meeting 2017 - Kalamazoo MI
Great Lakes Drug Metabolism and Deposition Group Meeting 2016 - Chicago IL
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