Lab Members‎ > ‎

Neil MacKinnon

nmackinn@umich.edu


Biophysics
930 N. University Ave.
Ann Arbor, MI, 48109

(734) 763-9318

Research Project

NMR investigations of cancer metabolomics utilizing cell line, urine and tissue samples. Particular focus is dedicated to Prostate Cancer.

Academic Background

Postdoctoral Fellow, September 2009 – Present
University of Michigan, Ann Arbor, MI
Mentor: Ayyalusamy Ramamoorthy

Ph.D – Chemistry , September 2004 – August 2009
University of Toronto, Toronto, ON
Advisor: Peter M. Macdonald
Thesis:  "Investigation of Unilamellar Phospholipid Vesicle Interactions with PNIPAM Based Hyrdogel Beads"

Publications

  • MacKinnon N, Ge W, Khan AP, Somashekar BS, Tripathi P, Siddiqui J, Wei JT, Chinnaiyan AM, Rajendiran TM, Ramamoorthy A.  Variable Reference Alignment: An Improved Peak Alignment Protocol for NMR Spectral Data with Large Intersample Variation, Analytical Chemistry 84 (2012) 5372-5379.
  • MacKinnon N, Khan AP, Chinnaiyan AM, Rajendiran TM, Ramamoorthy A.  Androgen receptor activation results in metabolite signatures of an aggressive prostate cancer phenotype: an NMR-based metabonomics study, Metabolomics (2012) doi:10.1007/s11306-012-0398-4.
  • MacKinnon N, Guerin G, Liu B, Gradinaru CC, Rubinstein JL, Macdonald PM.  Triggered Instability of Liposomes Bound to Hydrophobically Modified Core-Shell PNIPAM Hydrogel Beads, Langmuir 26 (2010) 1081-1089.
  • MacKinnon N, Guerrin G, Liu B, Gradinaru CC, Macdonald PM.  Liposome-Hydrogel Bead Complexes Prepared via Biotin-Avidin Conjugation, Langmuir 25 (2009) 9413-9423.
  • MacKinnon N, Ridgway J, Crowell KJ, Macdonald PM. Aluminum binding to phosphatidylcholine lipid bilayer membranes: aluminum exchange lifetimes from 31P NMR spectroscopy, Chemistry and Physics of Lipids 139 (2006) 85-95.
  • MacKinnon N, Crowell KJ, Udit AK, Macdonald PM.  Aluminum binding to phosphatidylcholine lipid bilayer membranes:  27Al and 31P NMR spectroscopic studies, Chemistry and Physics of Lipids 132 (2004) 23-36.

Conferences and Presentations

     Poster:            “Metabolomic Profiling of Prostate Cell Lines – Towards Non-Invasive Clinical Screening for Prostate Cancer”

Authors:          Neil MacKinnon, Vivekanandan Subramanian, Amjad P. Khan, Thekkelnaycke M. Rajendiran, Arul M. Chinnaiyan, Ayyalusamy Ramamoorthy

Location:         51st ENC, Daytona Beach, Florida, USA

Date:                April 18-23, 2010.      

 

Poster:            “Liposome Conjugated Microgels – Preparation and Characterization” 

Authors:           Neil MacKinnon, Qasim Saleem, Peter M. Macdonald

Location:          MOOT XXI, University of Windsor, Ontario, Canada

Date:                 October 4, 2008         

 

Presentation: “NMR Based Lateral Diffusion Measurements in Membranes”

Authors:          Neil MacKinnon, Peter M. Macdonald

Location:         Physical Chemistry Seminar, University of Toronto, Ontario, Canada

Date:                December 6, 2005

 

Presentation:  “Interaction of Aluminum with Phospholipid Bilayer Membranes”

Authors:           Neil MacKinnon, Peter M. Macdonald

Location:          MOOT XVIII, McMaster University, Hamilton, Ontario, Canada

Date:                 October 15, 2005