Lab Members‎ > ‎

Patrick Walsh

plwalsh@umich.edu

Biophysics
930 N. University Ave.
Ann Arbor, MI 48109

Academic Background

  Ph.D. in Biochemistry, 2013
  University of Toronto, Ontario, Canada
Advisor: Simon Sharpe
Thesis: "Structural Characterization and Membrane Interactions of the Amyloid Peptide PrP(106-126)"

Research project

  •    Solid State NMR Characterization of Amyloid Proteins and Peptides

Publications


  • Walsh, P., Vanderlee, G., Yau, J., Campeau, J., Sim, V., Yip, CM., and Sharpe, S. The Mechanism of Membrane Disruption by Cytotoxic Amyloid Oligomers Formed by PrP(106-126) is Dependent on Bilayer Composition. 2014. The Journal of Biological Chemistry.

  • Kotler, S., Walsh, P., Brender, J., and Ramamoorthy, A. Differences between amyloid-β aggregation in solution and on the membrane: Insights towards elucidation of the mechanistic details of Alzheimer’s disease. 2014. Chemical Society Reviews.   

  • Baldwin, AJ., Walsh, P., Hansen, DF., Hilton, GR, Benesch, JLP., Sharpe, S. and Kay, LE. Probing Dynamic Conformations of the High Molecular Weight αB-Crystallin Heat Shock Protein Ensemble by NMR Spectroscopy.  2012. Journal of the American Chemical Society. 134 (37)p 15343–15350.

  • Neudecker, P., Robustelli, P., Cavalli, A., Walsh, P., Lundström, P., Sharpe, S., Vendruscolo, M. and Kay, LE. Structure of an Intermediate State in Protein Folding and Aggregation. 2012. Science. 336 (6079), p 362-366.

  • Patrick Walsh and Simon Sharpe. Structure-Toxicity Relationships of Amyloid Peptide Oligomers. Advanced Understanding of Neurodegenerative Disease, Raymond Chuen-Chung Chang (Ed.). Intech.

  • Sharpe, S., Simonetti, K., Yau, J. and Walsh, P. Solid state NMR characterization of autofluorescent fibrils formed by the elastin-derived peptide GVGVAGVG. 2011. Biomacromolecules. 12, (5), p 1546-1555.

  • Walsh, P., Neudecker, P. and Sharpe, S. Structural Properties and Dynamic Behaviour of Nonfibrillar Oligomers Formed by PrP(106-126). 2010. Journal of the American Chemical Society. 132, p 7684-7695.

  • Walsh, P., Yau, J., Simonetti, K. and Sharpe S.  Morphology and Secondary Structure of Stable β-Oligomers formed by the Amyloid Peptide PrP(106-126). 2009. Biochemistry. 48, (25), p 5779-5781. *2009 American Chemical Society Top 10 Most Read Rapid Reports*

  • Walsh, P., Simonetti, K. and Sharpe, S. Core structure of amyloid fibrils formed by residues 106-126 of the human prion protein. 2009.  Structure. 17 (3) p 217-226.


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