Lab Members‎ > ‎

Bagganahalli Somashekar

bsoma@umich.edu


Biophysics
930 N. University Ave.
Ann Arbor, MI, 48109

(734) 763-9318

Academic Training

  • Post-doctoral Fellow (2011-present)       PI:  Prof. Ramamoorthy AR
    University of Michigan, Ann Arbor, Michigan
  • Post-doctoral Fellow (2008-2010)           PI:  Prof. Delphi Chatterjee
    Colorado State University, Fort Collins, Colorado
  • Ph.D (Chemistry), 2008                          Supervisor: Dr. Nagana Gowda GA
    Centre of Biomedical Magnetic Resonance, Lucknow, India
  • Master of Science (Chemistry), 2000
    Bangalore University, Bangalore

Research Interest

  • NMR Based Metabolomics of Tissues, Cell lines and Body fluids in Cancer and Tuberculosis Research.
  • Development of NMR methods for Metabolomics.

Publications

  1. Tripathi P*, Somashekar BS*, Ponnusamy M, Gursky A, Dailey S, Kunju P, Lee CT, Chinnaiyan AM, Rajendiran TM, Ramamoorthy A. HR-MAS NMR Tissue Metabolomic Signatures Cross-Validated by Mass Spectrometry Distinguish Bladder Cancer from Benign Disease. J Proteome Res. 2013 Jun 3 (Just Accepted). *equal contribution.
  2. MacKinnon N, Somashekar BS, Tripathi P, Ge W, Rajendiran TM, Chinnaiyan AM, Ramamoorthy A. MetaboID: a graphical user interface package for assignment of 1H NMR spectra of bodyfluids and tissues. J Magn Reson. 2013 Jan;226:93-9.
  3. Somashekar BS, Amin AG, Tripathi P, Mackinnon N, Rithner CD, Shanley CA, Basaraba R, Henao-Tamayo M, Kato-Maeda M, Ramamoorthy A, Orme IM, Ordway DJ, Chatterjee D. Metabolomic signatures in guinea pigs infected with epidemic associated W-Beijing strains of Mycobacterium tuberculosis J Proteome Res. 2012 Oct 5;11(10):4873-84.
  4. Tripathi P, Kamarajan P, Somashekar BS, Mackinnon N, Chinnaiyan AM, Kapila YL, Rajendiran TM, Ramamoorthy A. "Delineating metabolic signatures of head and neck squamous cell carcinoma: Phospholipase A(2), a potential therapeutic target". Int J Biochem Cell Biol. 44 (2012) 1852– 1861.
  5. Mackinnon N, Ge W, Khan AP, Somashekar BS, Tripathi P, Siddiqui J, Wei JT, Chinnaiyan AM, Rajendiran TM, Ramamoorthy A. "Variable reference alignment: an improved peak alignment protocol for NMR spectral data with large intersample variation". Anal Chem. 2012 Jun 19;84(12):5372-9.
  6. B.S. Somashekar, Kamarajan P, Danciu T, Kapila YL, Chinnaiyan AM, Rajendiran TM, Ramamoorthy A. "Magic Angle Spinning NMR Based Metabolic Profiling of Head and Neck Squamous Cell Carcinoma Tissues". J Proteome Res. 2011 Nov 4;10(11):5232-41.
  7. B. S. Somashekar, Amin AG, Rithner CD, Troudt J, Basaraba R, Izzo A, Crick DC, Chatterjee D. “Metabolomics of Lung Granulomas in Mycobacterium tuberculosis Infected Guinea pigs: ex vivo 1H Magic-Angle Spinning NMR Spectroscopic study”. J Proteome Resrearch. 2011 Sep 2;10(9):4186-95.
  8. M.E. Guerin ME, D Kaur, B. S. Somashekar, S Gibbs, P Gest, D Chatterjee, P J Brennan, M Jackson. "New insights into the early steps of phosphatidylinositol mannoside biosynthesis in mycobacteria: PimB' is an essential enzyme of Mycobacterium smegmatis". J. Biol. Chem. 2009 Sep 18;284(38):25687-96.
  9. K Ma, B. S. Somashekhar, G.A. Gowda, C.L Khetrapal. R.G. Weiss. "Room-temperature and low-ordered, amphotropic-lyotropic ionic liquid crystal phases induced by alcohols in phosphonium halides". Langmuir. 2008 Mar 18;24(6):2746-58.
  10. K Ma, A.A. Shahkhatuni, B. S. Somashekhar, G.A. Gowda, Y Tong, C.L Khetrapal. R.G. Weiss. "Induced amphotropic and thermotropic ionic liquid crystallinity in phosphonium halides: "lubrication" by hydroxyl groups". Langmuir. 2008 Sep 2;24(17):9843-54.
  11. Jadegoud Y, Ijare OB, B.S.Somashekar, G.A.Nagana Gowda, B. H. M. Mruthyunjayaswamy. "Synthesis, characterization and antimicrobial activity of homodinuclear complexes derived from 2,6- bis [3′-methyl- 2′-carboxamidyliminomethyl(6′,7′)benzindole]-4-methylphenol, an end-off compartmental ligand". Journal of Coordination Chemistry. 2008; 61(4) 508-527.
  12. S Tripathi, B. S. Somashekar, A.A Mahdi, A Gupta, F Mahdi, M Hasan, R Roy, C.L. Khetrapal. "Aluminum-mediated metabolic changes in rat serum and urine: a proton nuclear magnetic resonance study". J Biochem Mol Toxicol. 2008;22(2):119-27.
  13. G.A. Nagana Gowda, , Omkar B. Ijare, B. S. Somashekar, Ajay Sharma, V.K. Kapoor and C.L. Khetrapal. "Single-step analysis of individual conjugated bile acids in human bile using 1H NMR spectroscopy". Lipids, 41: 591-603, (June 2006).
  14. G.A. Nagana Gowda, B. S. Somashekar, Omkar B. Ijare, Ajay Sharma, V.K. Kapoor and C.L. Khetrapal. "One-step analysis of major bile components in human bile using 1H NMR spectroscopy". Lipids, 41: 577-589, (June 2006).
  15. B. S. Somashekar, Omkar B. Ijare, G.A. Nagana Gowda, V. Ramesh, Sushil Gupta and C.L. Khetrapal. "Simple pulse-acquire NMR methods for the quantitative analysis of calcium, magnesium and sodium in human serum". Spectrochim. Acta. Part A 65: 254-260.
  16. Omkar B. Ijare, B. S. Somashekar, Y. Jadegoud and G. A. Nagana Gowda. "1H and 13C NMR characterization and stereochemical assignments of bile acids in aqueous media". Lipids 40(10): 1031-1041, 2005.
  17. Omkar B. Ijare, B. S. Somashekar, G. A. Nagana Gowda, Ajay Sharma, V. K. Kapoor,  and C. L. Khetrapal. "Quantification of glycine and taurine conjugated bile acids in human bile using 1H NMR spectroscopy". Magn Reson Med 53:1441–1446, 2005.
  18. B. S. Somashekar, G.A. Nagana gowda, A.R. Ramesha and C.L.Khetrapal. "Protonation of trimipramine salts of maleate, mesylate and hydrochloride observed by 1H, 13C and 15N NMR spectroscopy". Magn. Reson. Chem. 43:166-170, 2005.
  19. B. S. Somashekar, G.A. Nagana gowda, A.R. Ramesha and C.L.Khetrapal. "Differential protonation and dynamic structure of doxylamine succinate in solution using 1H and 13C NMR". Magn. Reson. Chem. 42:636-640, 2004.