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Subramanian Vivekanandan

Research Specialist Lead (NMR specialist)

Department of Biophysics
930 N. University Ave.
Ann Arbor, MI, 48109-1055

Office: (734) 763-0329


Ph.D., Physics, Indian Institute of Science (IISc), Bangalore, India
M.Sc., Physics, Madras Christian College, Chennai, India

Research Project

NMR structural studies of membrane proteins and misfolded amyloid proteins.

  1. Insights into antiamyloidogenic properties of the green tea extract (−)-epigallocatechin-3-gallate toward metal-associated amyloid-β species. SJ Hyung, AS DeToma, JR Brender, S Lee,   S Vivekanandan, A Kochi, JS Choi, A Ramamoorthy.                                           Proceedings of the National Academy of Sciences 110 (10), 3743-3748, 2013
  2. Divergent Mechanisms in Amyloid Formation Controlled by Critical Points JR Brender,         J Krishnamoorthy, MFM Sciacca, S Vivekanandan, A Ramamoorthy.                      Biophysical Journal 104 (2), 51a, 2013
  3. Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide JR Brender, J Krishnamoorthy, GML Messina, A Deb, S Vivekanandan, C La Rosa, A Ramamoorthy.                 Chemical Communications (Camb) 49(32):3339-41 (2013).
  4. NMR solution structure of C2 domain of MFG-E8 and insights into its molecular recognition with phosphatidylserine. H Ye, B Li, S Vivekanandan, BH Choi, Y Liang, A Harikishore, G Chakraborty.                                                                           Biochimica et Biophysica Acta (BBA)-Biomembranes.1828(3):1083-93, 2013
  5. Side Chain Dynamics Reveals Transient Association of Aβ1-40 Monomers with Amyloid FibersJ Krishnamoorthy, JR Brender, S Vivekanandan, N Jahr, A Ramamoorthy.                         The Journal of Physical Chemistry B.116(46):13618-23, 2012
  6. Determination of 15N Chemical Shift Anisotropy from a Membrane-Bound Protein by NMR Spectroscopy. MK Pandey, S Vivekanandan, S Ahuja, K Pichumani, SC Im, L Waskell, A Ramamoorthy.                                                                                                    The Journal of Physical Chemistry B 116 (24), 7181-7189, 2012
  7. Site specific interaction of the polyphenol EGCG with the SEVI amyloid precursor peptide PAP (248–286)N Popovych, JR Brender, R Soong, S Vivekanandan, K Hartman, V Basrur, A Ramamoorthy.                                                                                                  The Journal of Physical Chemistry B 116 (11), 3650-3658, 2012
  8. NMR characterization of monomeric and oligomeric conformations of human calcitonin and its interaction with EGCGR Huang, S Vivekanandan, JR Brender, Y Abe, A Naito, A RamamoorthyJournal of Molecular Biology 416 (1), 108-120, 2012
  9. Tracking Conformational Changes during Amyloidogenesis in Real-Time at Atomic-Resolution by NMRJR Brender, S Vivekanandan, J Krishnamoorthy, MFM Sciacca, A Ramamoorthy.     Biophysical Journal 102, 242, 2012
  10. More Accurate 1JCH Coupling Measurement in the Presence of 3JHH Strong Coupling in Natural AbundanceB Yu, H van Ingen, S Vivekanandan, C Rademacher, SE Norris, DI Freedberg.  Journal of Magnetic Resonance,215:10-22, 2012
  11. Structure and membrane orientation of IAPP in its natively amidated form at physiological pH in a membrane environmentRPR Nanga, JR Brender, S Vivekanandan, A Ramamoorthy.    Biochimica et Biophysica Acta (BBA)-Biomembranes 1808 (10), 2337-2342, 2011
  12. Fast NMR Data Acquisition From Bicelles Containing a Membrane-Associated Peptide at Natural-AbundanceK Yamamoto, S Vivekanandan, A Ramamoorthy.                                      The Journal of Physical Chemistry B 115 (43), 12448-12455, 2011
  13. A partially folded structure of amyloid-beta (1–40) in an aqueous environment.               S Vivekanandan, JR Brender, SY Lee, A Ramamoorthy.                                                       Biochemical and Biophysical Research Communications 411 (2), 312-316, 2011
  14. A two-site mechanism for the inhibition of IAPP amyloidogenesis by zincS Salamekh, JR Brender, SJ Hyung, RPR Nanga, S Vivekanandan, BT Ruotolo, A Ramamoorthy.               Journal of molecular biology 410 (2), 294-306, 2011
  15. Inhibition of Amyloid Peptide Fibrillation by Inorganic Nanoparticles: Functional Similarities with ProteinsSI Yoo, M Yang, JR Brender, S Vivekanandan, K Sun, NE Joo, SH Jeong, A Ramamoorthy.                                                                                   Angewandte Chemie International Edition 123 (22), 5096-5096, 2011
  16. Inhibition of amyloid peptide fibrillation by inorganic nanoparticles: functional similarities with proteinsSI Yoo, M Yang, JR Brender, S Vivekanandan, K Sun, NE Joo, SH Jeong, A Ramamoorthy.                                                                                   Angewandte Chemie International Edition 50 (22), 5110-5115, 2011
  17. Role of zinc in human islet amyloid polypeptide aggregationJR Brender, K Hartman, RPR Nanga, N Popovych, R de la Salud Bea, S Vivekanandan, A Ramamoorthy.                   Journal of the American Chemical Society 132 (26), 8973, 2010
  18. Zinc Inhibits Human Islet Amyloid Polypeptide (IAPP) AmyloidogenesisK Hartman, JR Brender, S Vivekanandan, DW Youngstrom, A Ramamoorthy.                                                       Biophysical Journal 98, 255.
  19. Clues for the Mechanism of SEVI HIV Enhancement from Structural Studies of the SEVI Precursor Peptide PAP248-286 in a Membrane Environment by NMRRPR Nanga, JR Brender, S Vivekanandan, N Popovych, R Ayyalusamy.                                                            Biophysical Journal 98, 458, 2010
  20. Solution Structure, Determined by Nuclear Magnetic Resonance, of the b30-82 Domain of Subunit b of Escherichia coli F1Fo ATP Synthase.R Priya, G Biuković, S Gayen,                    S Vivekanandan, G Grüber.                                                                                                Journal of Bacteriology 191 (24), 7538-7544, 2009
  21. Why structurally different cyclic peptides can be glycomimetics of the HNK-1 carbohydrate antigen.A Bhunia, S Vivekanandan, T Eckert, M Burg-Roderfeld, R Wechselberger.                            Journal of the American Chemical Society 132 (1), 96-105, 2009
  22. NMR Structure in a Membrane Environment Reveals Putative Amyloidogenic Regions of the SEVI Precursor Peptide PAP248− 286.RPR Nanga, JR Brender, S Vivekanandan, N Popovych, A Ramamoorthy.                                                                                               Journal of the American Chemical Society 131 (49), 17972-17979, 2009
  23. Small molecule modulators of copper-induced Aβ aggregationSS Hindo, AM Mancino, JJ Braymer, Y Liu, S Vivekanandan, A Ramamoorthy, MH Lim.                                                 Journal of the American Chemical Society 131 (46), 16663-16665, 2009
  24. Three-dimensional structure and orientation of rat islet amyloid polypeptide protein in a membrane environment by solution NMR spectroscopy. RP Nanga, JR Brender, J Xu, K Hartman,               S Vivekanandan, A Ramamoorthy.                                                                             Journal of the American Chemical Society 131 (23), 8252, 2009
  25. Assembly of subunit d (Vma6p) and G (Vma10p) and the NMR solution structure of subunit G (G1–59) of the Saccharomyces cerevisiae V 1 V O ATPaseS Rishikesan, S Gayen, YR Thaker,                  S Vivekanandan, MSS Manimekalai, YH Yau.                                                                 Biochimica et Biophysica Acta (BBA)-Bioenergetics 1787 (4), 242-251, 2009
  26. Design of β-Hairpin Peptides for Modulation of Cell Adhesion by β-Turn ConstraintS Giddu, S Vivekanandan, HS Yoon, SD Satyanarayanajois.                                                          Journal of Medicinal Chemistry 52 (3), 726-736, 2009
  27. S1. 32 Intermediate positions of ATP on its trail to the binding pocket of subunit B and the high resolution structure of its neighbouring subunit F of the A1AO A1A0 ATP synthaseA Kumar, MSS Manimekalai, AM Balakrishna, S Gayen, S Vivekanandan, Goran Biukovic, Ho S Yoon, Gerhard Grüber                                                                                               Biochimica et Biophysica Acta (BBA)-Bioenergetics 1777, S17-S17, 2008
  28. Structure, Self-Assembly, and Dual Role of a β-Defensin-like Peptide from the Chinese Soft-Shelled Turtle Eggshell MatrixR Lakshminarayanan, S Vivekanandan, RP Samy, Y Banerjee, EO Chi-Jin, KW Teo.                                                                                     Journal of the American Chemical Society 130 (14), 4660-4668, 2008
  29. Biophysical Characterization of Anticoagulant Hemextin AB Complex from the Venom of Snake Hemachatus haemachatusY Banerjee, R Lakshminarayanan, S Vivekanandan, GS Anand, S Valiyaveettil.                                                                                     Biophysical journal 93 (11), 3963-3976, 2007
  30. NMR solution structure of subunit F of the methanogenic A1AO adenosine triphosphate synthase and its interaction with the nucleotide-binding subunit BS Gayen, S Vivekanandan, G Biukovic, G Grüber, HS Yoon.                                                                           Biochemistry 46 (42), 11684-11694, 2007
  31. 1 H, 13 C, and 15 N resonance assignments of subunit F of the A 1 A O ATP synthase from Methanosarcina mazei Gö1S Gayen, S Vivekanandan, G Biuković, G Grüber, HS YoonBiomolecular NMR Assignments 1 (1), 23-25, 2007
  32. Expression, purification and characterization of C2 domain of milk fat globule-EGF-factor 8-LRP Reddy Nanga, S Vivekanandan, HS Yoon.                                                                 Protein expression and purification 52 (2), 329-333, 2007
  33. Backbone 1 H, 13 C, and 15 N resonance assignments of the N-terminal domain of FKBP38 (FKBP38NTD)CB Kang, H Ye, S Vivekanandan, B Simon, M Sattler, HS Yoon.                            Journal of Biomolecular NMR 36, 37-37, 2006
  34. Hemextin AB Complex-a Unique Anticoagulant Protein Complex Inhibiting Clot Initiation from Snake VenomY Benerjee, J Mizuguchi, S Iwanaga, R Lakshminarayanan, S Vivekanandan, RM Kini.                                                                                                          The Journal of Japanese Society on Thrombosis, Vol 17, issue 5, page 562, 2006
  35. Human decorin leucine rich repeat 5 and its derivative peptides inhibit angiogenesis through multiple signaling pathwaysH Fan, KN Sulochana, S Jois, S Vivekanandan, F Sun, R Manjunatha Kini, R GeVascular Pharmacology 45 (3), e117-e118, 2006
  36. Effect of CTerminal Amidation on Folding and DisulfidePairing of αConotoxin ImI. TS Kang, S Vivekanandan, SDS Jois, RM Kini.                                                                      Angewandte Chemie International Edition 44 (39), 6333-6337, 2005
  37. Mimicking the Function of Eggshell Matrix Proteins: The Role of Multiplets of Charged Amino Acid Residues and SelfAssembly of Peptides in Biomineralization. PK Ajikumar,                        S Vivekanandan, R Lakshminarayanan, SDS Jois, RM Kini.                                               Angewandte Chemie International Edition 44 (34), 5476-5479, 2005
  38. Peptides derived from human decorin leucine-rich repeat 5 inhibit angiogenesisKN Sulochana, H Fan, S Jois, S Vivekanandan, F Sun, RM Kini, R Ge.                                          Journal of Biological Chemistry 280 (30), 27935-27948, 2005
  39. Determination of molecular structure by NMR using low order orientation in bicellesS Vivekanandan, A Joy, N Suryaprakash.                                                                    Journal of Molecular Structure 694 (1), 241-247, 2004
  40. Solid phase synthesis and solution structural studies of a 20-mer peptide: Diazepam Binding Inhibitor (human) 51-70PK Ajikumar, S Vivekanandan, SD Jois, KS Devaky.                          Biopolymers 71 (3), 363-363, 2003
  41. NMR spectra of mixed liquid crystals of opposite diamagnetic susceptibility anisotropies near critical point under variable angle sample spinning.                                                         S Vivekanandan, HS Vinay Deepak, GA Nagana Gowda, KV Ramanathan, CL Khetrapal.                          Journal of Molecular Structure 602, 485-489, 2002
  42. Novel method of estimating proton–proton dipolar couplings to aid the analyses of NMR spectra of oriented molecules using two-dimensional inverse experiment.                                          S Vivekanandan, N Suryaprakash.                                                                         Chemical Physics Letters 338 (4), 247-253, 2001 
  43. Natural Abundance 2H NMR Spectra of Molecules Oriented in Liquid CrystalsCL Khetrapal, KV Ramanathan, N Suryaprakash, S Vivekanandan.                                                                Journal of Magnetic Resonance 135 (1), 265-266, 1998
  44. Nematic mixture methods for the determination of chemical shift anisotropyCL Khetrapal, N Suryaprakash, S VivekanandanChemical physics letters 296 (5), 537-540, 1998
  45. Drug-lipid interactions in the model membrane, DPPC-water: A DSC and proton NMR studyKU Deniz, L Panicker, PS Parvathanathan, G Datta, S Vivekanandan, KV Ramanathan.                            Molecular Crystals and Liquid Crystals 288 (1), 237-247, 1996
  46. Multinuclear Magnetic Resonance Studies of Phenylphosphonic Dichloride Oriented in Nematic PhasesGA Naganagowda, S Vivekanandan, N Suryaprakash, CL Khetrapal.                                   Journal of Magnetic Resonance, Series A 118 (1), 33-38, 1996
  47. A Two Step Mechanism for the Inhibition of SEVI Amyloid Formation by EGCGN Popovych, JR Brender, R Soong, S Vivekanandan, K Hartman, PM Macdonald, A Ramamoorthy.                                J Phys Chem B. 116(11): 3650-3658.
  48. NMR Structural Studies of the Interactions between Mutants of Mammalian Microsomal Cytochrome b5 and Cytochrome P450SV Le Clair, S Ahuja, S Vivekanandan, N Popovych, SC Im, L Waskell, A Ramamoorthy. (Communicated)
  49. NMR Structure of a 70-kDa Complex Between Full-Length Cytochrome b5 and Cytochrome P450 in a Membrane MimeticS Ahuja, N Jahr, SC Im, S Vivekanandan, N Popovych, SV Le Clair, H Rui, NRP Nanga, R Soong, K Yamamoto, J Xu, L Waskell, A Ramamoorthy. (Communicated).
  50. 1H, 13C and 15N resonance assignments for the full-length mammalian cytochrome b5 in a membrane mimic environment S Vivekanandan, S Ahuja, SC Im, L Waskell and A Ramamoorthy (Communicated).