Department of Biophysics
930 N. University Ave.
Ann Arbor, MI, 48109-1055
Office: (734) 763-0329
Ph.D., Physics, Indian Institute of Science (IISc), Bangalore, India
M.Sc., Physics, Madras Christian College, Chennai, India
NMR structural studies of membrane proteins and misfolded amyloid proteins.
- Insights into antiamyloidogenic properties of the green tea extract (−)-epigallocatechin-3-gallate toward metal-associated amyloid-β species. SJ Hyung, AS DeToma, JR Brender, S Lee, S Vivekanandan, A Kochi, JS Choi, A Ramamoorthy. Proceedings of the National Academy of Sciences 110 (10), 3743-3748, 2013
- Divergent Mechanisms in Amyloid Formation Controlled by Critical Points JR Brender, J Krishnamoorthy, MFM Sciacca, S Vivekanandan, A Ramamoorthy. Biophysical Journal 104 (2), 51a, 2013
- Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide JR Brender, J Krishnamoorthy, GML Messina, A Deb, S Vivekanandan, C La Rosa, A Ramamoorthy. Chemical Communications (Camb) 49(32):3339-41 (2013).
- NMR solution structure of C2 domain of MFG-E8 and insights into its molecular recognition with phosphatidylserine. H Ye, B Li, S Vivekanandan, BH Choi, Y Liang, A Harikishore, G Chakraborty. Biochimica et Biophysica Acta (BBA)-Biomembranes.1828(3):1083-93, 2013
- Side Chain Dynamics Reveals Transient Association of Aβ1-40 Monomers with Amyloid Fibers. J Krishnamoorthy, JR Brender, S Vivekanandan, N Jahr, A Ramamoorthy. The Journal of Physical Chemistry B.116(46):13618-23, 2012
- Determination of 15N Chemical Shift Anisotropy from a Membrane-Bound Protein by NMR Spectroscopy. MK Pandey, S Vivekanandan, S Ahuja, K Pichumani, SC Im, L Waskell, A Ramamoorthy. The Journal of Physical Chemistry B 116 (24), 7181-7189, 2012
- Site specific interaction of the polyphenol EGCG with the SEVI amyloid precursor peptide PAP (248–286). N Popovych, JR Brender, R Soong, S Vivekanandan, K Hartman, V Basrur, A Ramamoorthy. The Journal of Physical Chemistry B 116 (11), 3650-3658, 2012
- NMR characterization of monomeric and oligomeric conformations of human calcitonin and its interaction with EGCG. R Huang, S Vivekanandan, JR Brender, Y Abe, A Naito, A Ramamoorthy. Journal of Molecular Biology 416 (1), 108-120, 2012
- Tracking Conformational Changes during Amyloidogenesis in Real-Time at Atomic-Resolution by NMR. JR Brender, S Vivekanandan, J Krishnamoorthy, MFM Sciacca, A Ramamoorthy. Biophysical Journal 102, 242, 2012
- More Accurate 1JCH Coupling Measurement in the Presence of 3JHH Strong Coupling in Natural Abundance. B Yu, H van Ingen, S Vivekanandan, C Rademacher, SE Norris, DI Freedberg. Journal of Magnetic Resonance,215:10-22, 2012
- Structure and membrane orientation of IAPP in its natively amidated form at physiological pH in a membrane environment. RPR Nanga, JR Brender, S Vivekanandan, A Ramamoorthy. Biochimica et Biophysica Acta (BBA)-Biomembranes 1808 (10), 2337-2342, 2011
- Fast NMR Data Acquisition From Bicelles Containing a Membrane-Associated Peptide at Natural-Abundance. K Yamamoto, S Vivekanandan, A Ramamoorthy. The Journal of Physical Chemistry B 115 (43), 12448-12455, 2011
- A partially folded structure of amyloid-beta (1–40) in an aqueous environment. S Vivekanandan, JR Brender, SY Lee, A Ramamoorthy. Biochemical and Biophysical Research Communications 411 (2), 312-316, 2011
- A two-site mechanism for the inhibition of IAPP amyloidogenesis by zinc. S Salamekh, JR Brender, SJ Hyung, RPR Nanga, S Vivekanandan, BT Ruotolo, A Ramamoorthy. Journal of molecular biology 410 (2), 294-306, 2011
- Inhibition of Amyloid Peptide Fibrillation by Inorganic Nanoparticles: Functional Similarities with Proteins. SI Yoo, M Yang, JR Brender, S Vivekanandan, K Sun, NE Joo, SH Jeong, A Ramamoorthy. Angewandte Chemie International Edition 123 (22), 5096-5096, 2011
- Inhibition of amyloid peptide fibrillation by inorganic nanoparticles: functional similarities with proteins. SI Yoo, M Yang, JR Brender, S Vivekanandan, K Sun, NE Joo, SH Jeong, A Ramamoorthy. Angewandte Chemie International Edition 50 (22), 5110-5115, 2011
- Role of zinc in human islet amyloid polypeptide aggregation. JR Brender, K Hartman, RPR Nanga, N Popovych, R de la Salud Bea, S Vivekanandan, A Ramamoorthy. Journal of the American Chemical Society 132 (26), 8973, 2010
- Zinc Inhibits Human Islet Amyloid Polypeptide (IAPP) Amyloidogenesis. K Hartman, JR Brender, S Vivekanandan, DW Youngstrom, A Ramamoorthy. Biophysical Journal 98, 255.
- Clues for the Mechanism of SEVI HIV Enhancement from Structural Studies of the SEVI Precursor Peptide PAP248-286 in a Membrane Environment by NMR. RPR Nanga, JR Brender, S Vivekanandan, N Popovych, R Ayyalusamy. Biophysical Journal 98, 458, 2010
- Solution Structure, Determined by Nuclear Magnetic Resonance, of the b30-82 Domain of Subunit b of Escherichia coli F1Fo ATP Synthase.R Priya, G Biuković, S Gayen, S Vivekanandan, G Grüber. Journal of Bacteriology 191 (24), 7538-7544, 2009
- Why structurally different cyclic peptides can be glycomimetics of the HNK-1 carbohydrate antigen.A Bhunia, S Vivekanandan, T Eckert, M Burg-Roderfeld, R Wechselberger. Journal of the American Chemical Society 132 (1), 96-105, 2009
- NMR Structure in a Membrane Environment Reveals Putative Amyloidogenic Regions of the SEVI Precursor Peptide PAP248− 286.RPR Nanga, JR Brender, S Vivekanandan, N Popovych, A Ramamoorthy. Journal of the American Chemical Society 131 (49), 17972-17979, 2009
- Small molecule modulators of copper-induced Aβ aggregation. SS Hindo, AM Mancino, JJ Braymer, Y Liu, S Vivekanandan, A Ramamoorthy, MH Lim. Journal of the American Chemical Society 131 (46), 16663-16665, 2009
- Three-dimensional structure and orientation of rat islet amyloid polypeptide protein in a membrane environment by solution NMR spectroscopy. RP Nanga, JR Brender, J Xu, K Hartman, S Vivekanandan, A Ramamoorthy. Journal of the American Chemical Society 131 (23), 8252, 2009
- Assembly of subunit d (Vma6p) and G (Vma10p) and the NMR solution structure of subunit G (G1–59) of the Saccharomyces cerevisiae V 1 V O ATPase. S Rishikesan, S Gayen, YR Thaker, S Vivekanandan, MSS Manimekalai, YH Yau. Biochimica et Biophysica Acta (BBA)-Bioenergetics 1787 (4), 242-251, 2009
- Design of β-Hairpin Peptides for Modulation of Cell Adhesion by β-Turn Constraint. S Giddu, S Vivekanandan, HS Yoon, SD Satyanarayanajois. Journal of Medicinal Chemistry 52 (3), 726-736, 2009
- S1. 32 Intermediate positions of ATP on its trail to the binding pocket of subunit B and the high resolution structure of its neighbouring subunit F of the A1AO A1A0 ATP synthase. A Kumar, MSS Manimekalai, AM Balakrishna, S Gayen, S Vivekanandan, Goran Biukovic, Ho S Yoon, Gerhard Grüber Biochimica et Biophysica Acta (BBA)-Bioenergetics 1777, S17-S17, 2008
- Structure, Self-Assembly, and Dual Role of a β-Defensin-like Peptide from the Chinese Soft-Shelled Turtle Eggshell Matrix. R Lakshminarayanan, S Vivekanandan, RP Samy, Y Banerjee, EO Chi-Jin, KW Teo. Journal of the American Chemical Society 130 (14), 4660-4668, 2008
- Biophysical Characterization of Anticoagulant Hemextin AB Complex from the Venom of Snake Hemachatus haemachatus. Y Banerjee, R Lakshminarayanan, S Vivekanandan, GS Anand, S Valiyaveettil. Biophysical journal 93 (11), 3963-3976, 2007
- NMR solution structure of subunit F of the methanogenic A1AO adenosine triphosphate synthase and its interaction with the nucleotide-binding subunit B. S Gayen, S Vivekanandan, G Biukovic, G Grüber, HS Yoon. Biochemistry 46 (42), 11684-11694, 2007
- 1 H, 13 C, and 15 N resonance assignments of subunit F of the A 1 A O ATP synthase from Methanosarcina mazei Gö1. S Gayen, S Vivekanandan, G Biuković, G Grüber, HS Yoon. Biomolecular NMR Assignments 1 (1), 23-25, 2007
- Expression, purification and characterization of C2 domain of milk fat globule-EGF-factor 8-L. RP Reddy Nanga, S Vivekanandan, HS Yoon. Protein expression and purification 52 (2), 329-333, 2007
- Backbone 1 H, 13 C, and 15 N resonance assignments of the N-terminal domain of FKBP38 (FKBP38NTD). CB Kang, H Ye, S Vivekanandan, B Simon, M Sattler, HS Yoon. Journal of Biomolecular NMR 36, 37-37, 2006
- Hemextin AB Complex-a Unique Anticoagulant Protein Complex Inhibiting Clot Initiation from Snake Venom. Y Benerjee, J Mizuguchi, S Iwanaga, R Lakshminarayanan, S Vivekanandan, RM Kini. The Journal of Japanese Society on Thrombosis, Vol 17, issue 5, page 562, 2006
- Human decorin leucine rich repeat 5 and its derivative peptides inhibit angiogenesis through multiple signaling pathways. H Fan, KN Sulochana, S Jois, S Vivekanandan, F Sun, R Manjunatha Kini, R Ge. Vascular Pharmacology 45 (3), e117-e118, 2006
- Effect of C‐Terminal Amidation on Folding and Disulfide‐Pairing of α‐Conotoxin ImI. TS Kang, S Vivekanandan, SDS Jois, RM Kini. Angewandte Chemie International Edition 44 (39), 6333-6337, 2005
- Mimicking the Function of Eggshell Matrix Proteins: The Role of Multiplets of Charged Amino Acid Residues and Self‐Assembly of Peptides in Biomineralization. PK Ajikumar, S Vivekanandan, R Lakshminarayanan, SDS Jois, RM Kini. Angewandte Chemie International Edition 44 (34), 5476-5479, 2005
- Peptides derived from human decorin leucine-rich repeat 5 inhibit angiogenesis. KN Sulochana, H Fan, S Jois, S Vivekanandan, F Sun, RM Kini, R Ge. Journal of Biological Chemistry 280 (30), 27935-27948, 2005
- Determination of molecular structure by NMR using low order orientation in bicelles. S Vivekanandan, A Joy, N Suryaprakash. Journal of Molecular Structure 694 (1), 241-247, 2004
- Solid phase synthesis and solution structural studies of a 20-mer peptide: Diazepam Binding Inhibitor (human) 51-70. PK Ajikumar, S Vivekanandan, SD Jois, KS Devaky. Biopolymers 71 (3), 363-363, 2003
- NMR spectra of mixed liquid crystals of opposite diamagnetic susceptibility anisotropies near critical point under variable angle sample spinning. S Vivekanandan, HS Vinay Deepak, GA Nagana Gowda, KV Ramanathan, CL Khetrapal. Journal of Molecular Structure 602, 485-489, 2002
- Novel method of estimating proton–proton dipolar couplings to aid the analyses of NMR spectra of oriented molecules using two-dimensional inverse experiment. S Vivekanandan, N Suryaprakash. Chemical Physics Letters 338 (4), 247-253, 2001
- Natural Abundance 2H NMR Spectra of Molecules Oriented in Liquid Crystals. CL Khetrapal, KV Ramanathan, N Suryaprakash, S Vivekanandan. Journal of Magnetic Resonance 135 (1), 265-266, 1998
- Nematic mixture methods for the determination of chemical shift anisotropy. CL Khetrapal, N Suryaprakash, S Vivekanandan. Chemical physics letters 296 (5), 537-540, 1998
- Drug-lipid interactions in the model membrane, DPPC-water: A DSC and proton NMR study. KU Deniz, L Panicker, PS Parvathanathan, G Datta, S Vivekanandan, KV Ramanathan. Molecular Crystals and Liquid Crystals 288 (1), 237-247, 1996
- Multinuclear Magnetic Resonance Studies of Phenylphosphonic Dichloride Oriented in Nematic Phases. GA Naganagowda, S Vivekanandan, N Suryaprakash, CL Khetrapal. Journal of Magnetic Resonance, Series A 118 (1), 33-38, 1996
- A Two Step Mechanism for the Inhibition of SEVI Amyloid Formation by EGCG. N Popovych, JR Brender, R Soong, S Vivekanandan, K Hartman, PM Macdonald, A Ramamoorthy. J Phys Chem B. 116(11): 3650-3658.
- NMR Structural Studies of the Interactions between Mutants of Mammalian Microsomal Cytochrome b5 and Cytochrome P450. SV Le Clair, S Ahuja, S Vivekanandan, N Popovych, SC Im, L Waskell, A Ramamoorthy. (Communicated)
- NMR Structure of a 70-kDa Complex Between Full-Length Cytochrome b5 and Cytochrome P450 in a Membrane Mimetic. S Ahuja, N Jahr, SC Im, S Vivekanandan, N Popovych, SV Le Clair, H Rui, NRP Nanga, R Soong, K Yamamoto, J Xu, L Waskell, A Ramamoorthy. (Communicated).