Department of Biophysics

930 N. University Ave.

Ann Arbor, MI, 48109-1055

Office: (734) 763-0329

Education

Ph.D., Physics, Indian Institute of Science (IISc), Bangalore, India

M.Sc., Physics, Madras Christian College, Chennai, India

Research Project

NMR structural studies of membrane proteins and misfolded amyloid proteins.

Link to Google Scholar

Publications

1. Insights into antiamyloidogenic properties of the green tea extract (−)-epigallocatechin-3-gallate toward metal-associated amyloid-β species. SJ Hyung, AS DeToma, JR Brender, S Lee, S Vivekanandan, A Kochi, JS Choi, A Ramamoorthy. Proceedings of the National Academy of Sciences 110 (10), 3743-3748, 2013
2. Divergent Mechanisms in Amyloid Formation Controlled by Critical Points JR Brender, J Krishnamoorthy, MFM Sciacca, S Vivekanandan, A Ramamoorthy. Biophysical Journal 104 (2), 51a, 2013
3. Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide JR Brender, J Krishnamoorthy, GML Messina, A Deb, S Vivekanandan, C La Rosa, A Ramamoorthy. Chemical Communications (Camb) 49(32):3339-41 (2013).
4. NMR solution structure of C2 domain of MFG-E8 and insights into its molecular recognition with phosphatidylserine. H Ye, B Li, S Vivekanandan, BH Choi, Y Liang, A Harikishore, G Chakraborty. Biochimica et Biophysica Acta (BBA)-Biomembranes.1828(3):1083-93, 2013
5. Side Chain Dynamics Reveals Transient Association of Aβ1-40 Monomers with Amyloid Fibers. J Krishnamoorthy, JR Brender, S Vivekanandan, N Jahr, A Ramamoorthy. The Journal of Physical Chemistry B.116(46):13618-23, 2012
6. Determination of 15N Chemical Shift Anisotropy from a Membrane-Bound Protein by NMR Spectroscopy. MK Pandey, S Vivekanandan, S Ahuja, K Pichumani, SC Im, L Waskell, A Ramamoorthy. The Journal of Physical Chemistry B 116 (24), 7181-7189, 2012
7. Site specific interaction of the polyphenol EGCG with the SEVI amyloid precursor peptide PAP (248–286). N Popovych, JR Brender, R Soong, S Vivekanandan, K Hartman, V Basrur, A Ramamoorthy. The Journal of Physical Chemistry B 116 (11), 3650-3658, 2012
8. NMR characterization of monomeric and oligomeric conformations of human calcitonin and its interaction with EGCG. R Huang, S Vivekanandan, JR Brender, Y Abe, A Naito, A Ramamoorthy. Journal of Molecular Biology 416 (1), 108-120, 2012
9. Tracking Conformational Changes during Amyloidogenesis in Real-Time at Atomic-Resolution by NMR. JR Brender, S Vivekanandan, J Krishnamoorthy, MFM Sciacca, A Ramamoorthy. Biophysical Journal 102, 242, 2012
10. More Accurate 1JCH Coupling Measurement in the Presence of 3JHH Strong Coupling in Natural Abundance. B Yu, H van Ingen, S Vivekanandan, C Rademacher, SE Norris, DI Freedberg. Journal of Magnetic Resonance,215:10-22, 2012
11. Structure and membrane orientation of IAPP in its natively amidated form at physiological pH in a membrane environment. RPR Nanga, JR Brender, S Vivekanandan, A Ramamoorthy. Biochimica et Biophysica Acta (BBA)-Biomembranes 1808 (10), 2337-2342, 2011
12. Fast NMR Data Acquisition From Bicelles Containing a Membrane-Associated Peptide at Natural-Abundance. K Yamamoto, S Vivekanandan, A Ramamoorthy. The Journal of Physical Chemistry B 115 (43), 12448-12455, 2011
13. A partially folded structure of amyloid-beta (1–40) in an aqueous environment. S Vivekanandan, JR Brender, SY Lee, A Ramamoorthy. Biochemical and Biophysical Research Communications 411 (2), 312-316, 2011
14. A two-site mechanism for the inhibition of IAPP amyloidogenesis by zinc. S Salamekh, JR Brender, SJ Hyung, RPR Nanga, S Vivekanandan, BT Ruotolo, A Ramamoorthy. Journal of molecular biology 410 (2), 294-306, 2011
15. Inhibition of Amyloid Peptide Fibrillation by Inorganic Nanoparticles: Functional Similarities with Proteins. SI Yoo, M Yang, JR Brender, S Vivekanandan, K Sun, NE Joo, SH Jeong, A Ramamoorthy. Angewandte Chemie International Edition 123 (22), 5096-5096, 2011
16. Inhibition of amyloid peptide fibrillation by inorganic nanoparticles: functional similarities with proteins. SI Yoo, M Yang, JR Brender, S Vivekanandan, K Sun, NE Joo, SH Jeong, A Ramamoorthy. Angewandte Chemie International Edition 50 (22), 5110-5115, 2011
17. Role of zinc in human islet amyloid polypeptide aggregation. JR Brender, K Hartman, RPR Nanga, N Popovych, R de la Salud Bea, S Vivekanandan, A Ramamoorthy. Journal of the American Chemical Society 132 (26), 8973, 2010
18. Zinc Inhibits Human Islet Amyloid Polypeptide (IAPP) Amyloidogenesis. K Hartman, JR Brender, S Vivekanandan, DW Youngstrom, A Ramamoorthy. Biophysical Journal 98, 255.
19. Clues for the Mechanism of SEVI HIV Enhancement from Structural Studies of the SEVI Precursor Peptide PAP248-286 in a Membrane Environment by NMR. RPR Nanga, JR Brender, S Vivekanandan, N Popovych, R Ayyalusamy. Biophysical Journal 98, 458, 2010
20. Solution Structure, Determined by Nuclear Magnetic Resonance, of the b30-82 Domain of Subunit b of Escherichia coli F1Fo ATP Synthase.R Priya, G Biuković, S Gayen, S Vivekanandan, G Grüber. Journal of Bacteriology 191 (24), 7538-7544, 2009
21. Why structurally different cyclic peptides can be glycomimetics of the HNK-1 carbohydrate antigen.A Bhunia, S Vivekanandan, T Eckert, M Burg-Roderfeld, R Wechselberger. Journal of the American Chemical Society 132 (1), 96-105, 2009
22. NMR Structure in a Membrane Environment Reveals Putative Amyloidogenic Regions of the SEVI Precursor Peptide PAP248− 286.RPR Nanga, JR Brender, S Vivekanandan, N Popovych, A Ramamoorthy. Journal of the American Chemical Society 131 (49), 17972-17979, 2009
23. Small molecule modulators of copper-induced Aβ aggregation. SS Hindo, AM Mancino, JJ Braymer, Y Liu, S Vivekanandan, A Ramamoorthy, MH Lim. Journal of the American Chemical Society 131 (46), 16663-16665, 2009
24. Three-dimensional structure and orientation of rat islet amyloid polypeptide protein in a membrane environment by solution NMR spectroscopy. RP Nanga, JR Brender, J Xu, K Hartman, S Vivekanandan, A Ramamoorthy. Journal of the American Chemical Society 131 (23), 8252, 2009
25. Assembly of subunit d (Vma6p) and G (Vma10p) and the NMR solution structure of subunit G (G1–59) of the Saccharomyces cerevisiae V 1 V O ATPase. S Rishikesan, S Gayen, YR Thaker, S Vivekanandan, MSS Manimekalai, YH Yau. Biochimica et Biophysica Acta (BBA)-Bioenergetics 1787 (4), 242-251, 2009
26. Design of β-Hairpin Peptides for Modulation of Cell Adhesion by β-Turn Constraint. S Giddu, S Vivekanandan, HS Yoon, SD Satyanarayanajois. Journal of Medicinal Chemistry 52 (3), 726-736, 2009
27. S1. 32 Intermediate positions of ATP on its trail to the binding pocket of subunit B and the high resolution structure of its neighbouring subunit F of the A1AO A1A0 ATP synthase. A Kumar, MSS Manimekalai, AM Balakrishna, S Gayen, S Vivekanandan, Goran Biukovic, Ho S Yoon, Gerhard Grüber Biochimica et Biophysica Acta (BBA)-Bioenergetics 1777, S17-S17, 2008
28. Structure, Self-Assembly, and Dual Role of a β-Defensin-like Peptide from the Chinese Soft-Shelled Turtle Eggshell Matrix. R Lakshminarayanan, S Vivekanandan, RP Samy, Y Banerjee, EO Chi-Jin, KW Teo. Journal of the American Chemical Society 130 (14), 4660-4668, 2008
29. Biophysical Characterization of Anticoagulant Hemextin AB Complex from the Venom of Snake Hemachatus haemachatus. Y Banerjee, R Lakshminarayanan, S Vivekanandan, GS Anand, S Valiyaveettil. Biophysical journal 93 (11), 3963-3976, 2007
30. NMR solution structure of subunit F of the methanogenic A1AO adenosine triphosphate synthase and its interaction with the nucleotide-binding subunit B. S Gayen, S Vivekanandan, G Biukovic, G Grüber, HS Yoon. Biochemistry 46 (42), 11684-11694, 2007
31. 1 H, 13 C, and 15 N resonance assignments of subunit F of the A 1 A O ATP synthase from Methanosarcina mazei Gö1. S Gayen, S Vivekanandan, G Biuković, G Grüber, HS Yoon. Biomolecular NMR Assignments 1 (1), 23-25, 2007
32. Expression, purification and characterization of C2 domain of milk fat globule-EGF-factor 8-L. RP Reddy Nanga, S Vivekanandan, HS Yoon. Protein expression and purification 52 (2), 329-333, 2007
33. Backbone 1 H, 13 C, and 15 N resonance assignments of the N-terminal domain of FKBP38 (FKBP38NTD). CB Kang, H Ye, S Vivekanandan, B Simon, M Sattler, HS Yoon. Journal of Biomolecular NMR 36, 37-37, 2006
34. Hemextin AB Complex-a Unique Anticoagulant Protein Complex Inhibiting Clot Initiation from Snake Venom. Y Benerjee, J Mizuguchi, S Iwanaga, R Lakshminarayanan, S Vivekanandan, RM Kini. The Journal of Japanese Society on Thrombosis, Vol 17, issue 5, page 562, 2006
35. Human decorin leucine rich repeat 5 and its derivative peptides inhibit angiogenesis through multiple signaling pathways. H Fan, KN Sulochana, S Jois, S Vivekanandan, F Sun, R Manjunatha Kini, R Ge. Vascular Pharmacology 45 (3), e117-e118, 2006
36. Effect of C‐Terminal Amidation on Folding and Disulfide‐Pairing of α‐Conotoxin ImI. TS Kang, S Vivekanandan, SDS Jois, RM Kini. Angewandte Chemie International Edition 44 (39), 6333-6337, 2005
37. Mimicking the Function of Eggshell Matrix Proteins: The Role of Multiplets of Charged Amino Acid Residues and Self‐Assembly of Peptides in Biomineralization. PK Ajikumar, S Vivekanandan, R Lakshminarayanan, SDS Jois, RM Kini. Angewandte Chemie International Edition 44 (34), 5476-5479, 2005
38. Peptides derived from human decorin leucine-rich repeat 5 inhibit angiogenesis. KN Sulochana, H Fan, S Jois, S Vivekanandan, F Sun, RM Kini, R Ge. Journal of Biological Chemistry 280 (30), 27935-27948, 2005
39. Determination of molecular structure by NMR using low order orientation in bicelles. S Vivekanandan, A Joy, N Suryaprakash. Journal of Molecular Structure 694 (1), 241-247, 2004
40. Solid phase synthesis and solution structural studies of a 20-mer peptide: Diazepam Binding Inhibitor (human) 51-70. PK Ajikumar, S Vivekanandan, SD Jois, KS Devaky. Biopolymers 71 (3), 363-363, 2003
41. NMR spectra of mixed liquid crystals of opposite diamagnetic susceptibility anisotropies near critical point under variable angle sample spinning. S Vivekanandan, HS Vinay Deepak, GA Nagana Gowda, KV Ramanathan, CL Khetrapal. Journal of Molecular Structure 602, 485-489, 2002
42. Novel method of estimating proton–proton dipolar couplings to aid the analyses of NMR spectra of oriented molecules using two-dimensional inverse experiment. S Vivekanandan, N Suryaprakash. Chemical Physics Letters 338 (4), 247-253, 2001
43. Natural Abundance 2H NMR Spectra of Molecules Oriented in Liquid Crystals. CL Khetrapal, KV Ramanathan, N Suryaprakash, S Vivekanandan. Journal of Magnetic Resonance 135 (1), 265-266, 1998
44. Nematic mixture methods for the determination of chemical shift anisotropy. CL Khetrapal, N Suryaprakash, S Vivekanandan. Chemical physics letters 296 (5), 537-540, 1998
45. Drug-lipid interactions in the model membrane, DPPC-water: A DSC and proton NMR study. KU Deniz, L Panicker, PS Parvathanathan, G Datta, S Vivekanandan, KV Ramanathan. Molecular Crystals and Liquid Crystals 288 (1), 237-247, 1996
46. Multinuclear Magnetic Resonance Studies of Phenylphosphonic Dichloride Oriented in Nematic Phases. GA Naganagowda, S Vivekanandan, N Suryaprakash, CL Khetrapal. Journal of Magnetic Resonance, Series A 118 (1), 33-38, 1996
47. A Two Step Mechanism for the Inhibition of SEVI Amyloid Formation by EGCG. N Popovych, JR Brender, R Soong, S Vivekanandan, K Hartman, PM Macdonald, A Ramamoorthy. J Phys Chem B. 116(11): 3650-3658.
48. NMR Structural Studies of the Interactions between Mutants of Mammalian Microsomal Cytochrome b5 and Cytochrome P450. SV Le Clair, S Ahuja, S Vivekanandan, N Popovych, SC Im, L Waskell, A Ramamoorthy. (Communicated)
49. NMR Structure of a 70-kDa Complex Between Full-Length Cytochrome b5 and Cytochrome P450 in a Membrane Mimetic. S Ahuja, N Jahr, SC Im, S Vivekanandan, N Popovych, SV Le Clair, H Rui, NRP Nanga, R Soong, K Yamamoto, J Xu, L Waskell, A Ramamoorthy. (Communicated).