Ramamoorthy (Rams) lab is relocated at FSU!
https://eng.famu.fsu.edu/cbe/people/ramamoorthy
https://sites.google.com/view/ramslab-fsu-maglab?usp=sharing
Ramamoorthy lab - Summer 2022
News
*Welcome to Nazifa Tasnim Ahmad, Graduate Student, Biomedical Engineering!
*Welcome to Falak Syad, Graduate Student, Biomedical Engineering!
*Welcome to Dr. Naiem Wani, Post-Doctoral Fellow!
*Welcome to Dr. Pradeepraj Durairaj, Post-Doctoral Fellow!
*Welcome to Nabila Bushra, a Physics Graduate Student from the University of South Florida, Tampa, to the Rams Lab!
*Welcome to Debasmita Banerjee, Biophysics Graduate Student, FSU to the Rams Lab!
*Welcome to Sarayu Vanga, High School Student, to the Rams Lab!
*Welcome to Dr. Jhinuk Saha, a post-doctoral fellow, to the new lab!
*Welcome to Dr. Malitha C Dickwella Widanage, a post-doctoral fellow, to the new lab!
*Samuel McCalpin (jointly with Dr. Ivanova), Volodymyr Hiiuk (jointly with Prof. Nagorny), Gaurav Sharma (jointly with Dr. Ivanova), and Zhizhuo Zhang (jointly with Dr. Ivanova) are continuing at Michigan.
Prof. Rams Ramamoorthy joins NHMFL+FSU on Aug. 01, 2023.
Website in progress: https://nationalmaglab.org/staff/?name=AyyalusamyRamamoorthy
Transitioning: Professor Ramamoorthy will be joining NHMFL (https://nationalmaglab.org/) and the Chemical & Biomedical Engineering Department at FAMU-FSU in Tallahassee on August 01, 2023.
https://eng.famu.fsu.edu/cbe
Congratulations, Krishna, Gaurav and Thiru!
"Characterization of nanodisc-forming peptides for membrane protein studies", Krishnarjuna B, Sharma G, Im SC, Auchus R, Anantharamaiah GM, Ramamoorthy A. J Colloid Interface Sci. 2023 Sep 29;653(Pt B):1402-1414.
Congratulations, Sam, Malitha and Riqiang!
"On-Pathway Oligomer of Human Islet Amyloid Polypeptide Induced and Stabilized by Mechanical Rotation During MAS NMR", McCalpin, Samuel; Widanage, Malitha ; Fu, Riqiang; Ramamoorthy, Ayyalusamy. J. Phys. Chem. Letters (in press).
Congratulations, Bikash!
Direct interaction between the transmembrane helices stabilize cytochrome P450 2B4 and cytochrome b5 redox complex, Bikash R. Sahoo, Ayyalusamy Ramamoorthy, Biophys. Chem. (in press).
Congratulations, Manjeet!
Non-micellar ganglioside GM1 induces an instantaneous conformational change in Aβ42 leading to the modulation of the peptide amyloid-fibril pathway, Manjeet Kumar, Magdalena Ivanova, Ayyalusamy Ramamoorthy, Biophys. Chem. (in press).
Krishna has accepted an offer from Michigan State University to join the Tuo Wang lab. Congratulations, Krishna!
Congratulations, Manjeet!
Kumar M, I Ivanova M, Ramamoorthy A. Ganglioside GM1 produces stable, short, and cytotoxic Aβ40 protofibrils. Chem Commun (Camb). 2023 Jun 6;59(46):7040-7043.
*Welcoming Lina-Cerine Mechakra, Visiting Master's Student, CY Cergy Paris Universite, France
Congratulations Mary Muter for the summer fellowship award!
Congratulations Zhizhuo Zhang for the summer fellowship award!
*Welcoming Volodymyr Hiiuk, Research Fellow!
*Welcoming Dr. Malitha C Dickwella Widanage, a post-doctoral fellow!
Congratulations, Sam!
Magnetically aligned nanodiscs enable direct measurement of 17O residual quadrupolar coupling for small molecules. McCalpin SD, Fu R, Ravula T, Wu G, Ramamoorthy A.
J Magn Reson. 2023 Jan;346:107341. doi: 10.1016/j.jmr.2022.107341.
Congratulations Team for this wonderful product resulting from QFR (Quarantine From Reality) period!
Ultrafast Magic Angle Spinning Solid-State NMR Spectroscopy: Advances in Methodology and Applications. Nishiyama Y, Hou G, Agarwal V, Su Y, Ramamoorthy A.
Chem Rev. 2022 Dec 21. doi: 10.1021/acs.chemrev.2c00197.
Congratulations, Krishna!
Enhancing the stability and homogeneity of non-ionic polymer nanodiscs by tuning electrostatic interactions. Krishnarjuna B, Marte J, Ravula T, Ramamoorthy A.
J Colloid Interface Sci. 2022 Dec 21;634:887-896. doi: 10.1016/j.jcis.2022.12.112.
Congratulations, Sam, Bikash, and Argo!
Free Gangliosides Can Alter Amyloid-β Aggregation.
Chakravorty A, McCalpin SD, Sahoo BR, Ramamoorthy A, Brooks CL 3rd.
J Phys Chem Lett. 2022 Sep 29:9303-9308.
*Welcoming Dr. Gaurav Sharma, a post-doctoral fellow!
*Welcoming NamHoon Kim, undergraduate researcher!
*Welcoming Bishvanwesha Panda, a graduate student from Chemistry!
Congratulations, Krishna, Thiru, and Joseph!
"Non-ionic inulin-based polymer-nanodiscs enable functional reconstitution of a redox complex composed of oppositely charged CYP450 and CPR in a lipid bilayer membrane"
Author(s): Krishnarjuna, Bankala; Im, Sang-Choul; Ravula, Thirupathi; Marte, Joseph; Auchus, Richard; Ramamoorthy, Ayyalusamy, Analytical Chemistry 94,11908-11915.
Congratulations, Krishna!
"Detergent-Free Isolation of Membrane Proteins and Strategies to Study Them in a Near-Native Membrane Environment", Krishnarjuna B and Ramamoorthy A, Biomolecules; 12, 1076 (2022).
Welcoming a post-doctoral fellow, Dr. Manjeet Kumar, to the lab.
Welcoming an undergraduate student, Mary Muter, to the lab.
Congratulations, Krishna and Thiru!
"Detergent-free isolation of CYP450-reductase’s FMN-binding domain in E.coli lipid-nanodiscs using a charge-free polymer"
Bankala Krishnarjuna, Thirupathi Ravula, and Ayyalusamy Ramamoorthy, Chemical Communications 58, 4913-4916.
Sam publishes his first paper!
Congratulations, Sam and Thiru!
"Saponins Form Nonionic Lipid Nanodiscs for Protein Structural
Studies by Nuclear Magnetic Resonance Spectroscopy"
Samuel D. McCalpin, Thirupathi Ravula, and Ayyalusamy Ramamoorthy,
J. Phys. Chem. Letters (in press, 2022)
Srikar's NMR-Music study is published! Congratulations, Srikar!
This is an educational project.
Munukutla S, Bertoy A, Rush S, Ramamoorthy A. "Molecular Music: A Modern Accompaniment to NMR Pedagogy." Journal of Chemical Education (2022).
Thiru's "aligned & 90°-flipped nanodiscs" is published! Congratulations, Thiru!
Ravula T, Ramamoorthy A. "Measurement of Residual Dipolar Couplings Using Magnetically Aligned and Flipped Nanodiscs." Langmuir 38(1):244-252 (2022).
Bikash's IAPP study is published! Congratulations, Bikash!
Sahoo BR, Souders CL 2nd, Watanabe-Nakayama T, Deng Z, Linton H, Suladze S, Ivanova MI, Reif B, Ando T, Martyniuk CJ, Ramamoorthy A. "Conformational Tuning of Amylin by Charged Styrene-Maleic-Acid Copolymers." J Mol Biol. 434(2):167385 (2022).
Welcoming a post-doctoral fellow Dr. Mohammad Hajipour!
Congratulation Thiru on his new job! Thiru joins the NMRFAM at the University of Wisconsin.
Thiru's manuscript accepted for publication - Congratulations, Thiru!
"Synthesis, Characterization, and Nanodisc formation of Non-ionic Polymers", Angew.Chem. (2021).
"A Solid-State NMR Study to Probe the Effects of Divalent Metal Ions (Ca2+ and Mg2+) on the Magnetic-Alignment of Polymer Based Lipid‐Nanodiscs", Langmuir (2021).
Krishna's manuscripts accepted for publication - Congratulations, Krishna!
"Nanodisc reconstitution of flavin mononucleotide binding domain of cytochrome-P450-reductase enables high-resolution NMR probing", Chemical Communications (2021).
"Solid-state packing dictates the unexpected solubility of aromatic peptides", Cell Reports Physical Science (2021).
see GenScript links on Krishna's publication on the direct 'detergent-free' extraction of cyt-b5:
https://www.molecularcloud.org/p/winners-announced-of-membrane-protein-extraction-campaign
Congratulations, Bikash!
"Degradation of Alzheimer’s amyloid-β by a catalytically inactive insulin-degrading enzyme", Journal of Molecular Biology (2021).
"Investigation of the effects of two major secretory granules components, insulin and zinc, on human-IAPP amyloid aggregation and membrane damage", Chemistry and Physics of Lipids (2021).
Bikash joined the HHMI institute as a staff scientist to work in the lab of Professor James Bardwell at Michigan.
Congratulations, Katya (Katerina Kornievskaia) on your being awarded the summer undergraduate research fellowship from the Chemistry Department!
Congratulations, Dr. Giacomo Di Mauro!
Giacomo's manuscript is now accepted for publication in Langmuir (Feb.2021).
Giacomo successfully defends thesis research and graduates with a PhD degree in Chemistry (Dec.2020).
Giacomo is joining Professor Matthias Buck's research group in the Physiology and Biophysics Department at Case Western Reserve University, Cleveland (https://physiology.case.edu/research/labs/buck-lab/). (Jan.2021)
Congratulations to the Rams-lab Alumni
Dr. Mohammad Hajipour accepts a Research Scientist position at Stanford University.
Dr. Thirupathi Ravula joins NMRFAM, University of Wisconsin - Madison.
Dr. Rui Huang becomes an Assistant Professor of Chemistry position at the University of Guelph, Canada.
Dr. Vojc Kocman accepted a faculty position at the Slovenian NMR Centre, Slovenia.
Dr. Joshua Damron becomes a Scientist at the Oakridge National Lab, Tennessee, USA.
Dr. Jeffrey Brender becomes a Staff Scientist at NCI, NIH.
Dr. Nathaniel Hardin accepts a position at Savannah River National Lab, South Carolina USA.
The Rams-lab welcomes Samuel McCalpin, a Chemistry Rotation student!
The Rams-lab welcomes Najae Escoffery, a Chemistry Rotation student!
Welcome to Adithi Voleti, a PreMed
undergradaute student at UM
avoleti@umich.edu
December 2020
Welcome Katerina Kornievskaia (Katya), an undergraduate student at UM. katalice@umich.edu
The Ramamoorthy lab welcomes a new virtual member: Katya!
Fun facts: I am a junior majoring in biochemistry and I will be researching the role of metals in IAPP aggregation, as well as their effect on the environment. After graduating, I will be applying to medical schools to earn an MD. Also I am fluent in Russian, I love rock climbing, and I summited my first mountain (Mt. Washington in New Hampshire) this past summer.
September 2020
Welcome Stanislav Cherepanov!
The Ramamoorthy lab welcomes a Biophysics rotation student.
Welcome Srikar Munukutla!
The Ramamoorthy lab welcomes his first "virtual member" Srikar, who will be studying the musical aspects of NMR spectroscopy!
Srikar Munukutla obtained his BS in Biology, Health, and Society from the University of Michigan, Ann Arbor in 2020. His past research interests include identifying molecular mechanisms in diabetes and related heart diseases. He holds a strong interest in NMR, and wishes to pursue its applications to biology as well as education.
August 2020
Molecular Bases of Proteinopathies
A virtual meeting of talks, activities, and discussion on "protein multimerization: the bad and the good"
Congratulations Nate for the post-doctoral fellow position in the Professor Bart's lab. Now (Jan.2021), joining the Savannah River National Lab! Best wishes.
January 2020
Nathaniel Hardin's Dissertation Defense - January 9th
January 9th - Nate successfully defended his dissertation with the title "Synthesis and Characterization of Polymers and Development of Polymer Based Lipid-Nanodiscs".
Congratulations on your Ph.D. in Chemistry, Dr. Nate!
December 2019
Congratulations Sarah for the post-doctoral fellow position at the National University of Singapore! Best wishes.
Sarah Cox's Dissertation Defense - December 6th
December 6th - Sarah Cox successfully defended her dissertation with the title "Biophysical Characterization of Amyloid Disease-Related Peptides Using Small Molecule Tools".
The entire Ramamoorthy lab fully supported her with a customized T-shirt.
Congratulations on your Ph.D. in Chemistry, Dr. Cox!
November 2019
Rams' Inaugural Lecture - November 17th
November 17th - Excellent talk from Ayyalusamy Ramamoorthy, a.k.a. Rams, on "Probing Membrane-Assisted Dynamic Protein-Protein Interactions by NMR".
What a great support from the lab members!
#gorams
Rams' Inaugural Lecture - November 17th
November 4th - Mark your calendar and join us on November 11th at 4:00 PM at the 10th floor of Weiser Hall at the University of Michigan.
Professor Ayyalusamy Ramamoorthy, the Robert W. Parry Collegiate Professor of Chemistry and Biophysics, Inaugural Lecture will present his latest research about "Probing Membrane-Assisted Dynamic Protein-Protein Interactions by NMR".
More information are available here.
October 2019
Rams visited Nankai University in China
Check this out.
Students abroad love the University of Michigan and support Rams' Lab.
#goblue #gorams
Amazing seminar from Dr. Jennifer Lee from NIH
October 17th - Dr. Jennifer Lee from NIH, Bethesda, MD, USA visited our lab.
Thank you for such a great talk about "Membrane Interactions and Amyloid Formation of alpha-Synuclein".
Biophysics Annual Retreat 2019
October 21st - Rams lab participate to the Annual Biophysics Retreat 2019 at the Washtenaw Golf Club in Ypsilanti, MI.
A lovely day sharinging our latest data with the Biophysics community at the University of Michigan, recruting new students.
New website for the Rams lab
October 7th - A new website is officially available for the Rams lab. Enjoy!
Biophysics Graduate Student Seminar
October 4th - Congratulations to Dr. Bikash Sahoo for his amazing talk on "Nanodiscs: A powerful tool to probe protein misfolding and amyloid aggregation".
The whole lab participated offering great (and customized) support!
October 1st - We are pleased to welcome Jesse and Joseph.
Jesse is a Biophysics Ph.D. student, rotating in our lab for the Fall 2019 semester.
Joseph, after a collaboration during the Spring/Summer '17 term, is back to the Ramamoorthy lab for the Fall '19 semester.
September 2019
Thank you Dr. Subramaniam Ganapathy!
We kindly thank Dr. Ganapathy for his valuable help during the time spent visiting our lab. He is now back to India where more students can benefit of his skills
See you soon!
Great success for the Gateway NMR Meeting
September 22nd, 2019
Thank you all for coming, see you all in 2020!
Seminar from Prof. Haribabu Arthanari
September 20th, 2019
Thanks to prof. Haribabu Arthanari from Harvard University and Dana-Farber Cancer Institute for his amazing talk about "Emerging methods in solution NMR and applications to illuminate blind spots in human biology".
Check out our upcoming event! A 2-day full-immersion NMR meeting is heading to the University of Michigan. Click here for more information and find out the schedule and the list of key note and invited speakers.
Great Seminar from prof. Lucia Banci
September 2nd, 2019
Prof. Lucia Banci from CERM, Florence, Italy visited our lab.
Thank you for such an amazing talk about "In Vivo NMR".
In the picture, from left-to-right: Thirupathi, Rams, Lucia Banci, Giacomo.
Lab member's Highlights
Nate Hardin obtains his Ph.D.! January, 2020. Congratulations, Dr. (Fancy) Nate!
Sarah Cox obtains her Ph.D.! December, 2019. Congratulations, Dr. Sarah!
Katie Gentry obtains her Ph.D! December, 2018
Congratulations to Katie for receiving a Rackham Predoctoral Fellowship!
Joshua Damron obtains his Ph.D.! March 14, 2018
Congratulations, Dr. Josh!
Kian Kamgar-Parsi obtains his Ph.D! December 14, 2017
Congratulations, Dr. Kian!
Congratulations to Kian and Sarah for both winning a poster competition award! - International Conference on Protein Misfolded Diseases, Catania, Sicily, Italy (July 31-August 3 2017)
Kyle Korshavn obtains his Ph.D! December 14, 2016
Congratulations, Dr. Kyle!
Congratulations to Rams for winning a Distinguished Faculty Achievement Award!
Read the article here!
Congratulations to Kyle for winning a Conference Travel Grant for his wonderful talk at the Karle Symposium!
Congratulations to Kyle for receiving the Henry Earle Riggs Dissertation Fellowship!
Meng Zhang obtains her Ph.D! May 13, 2016
Congratulations, Dr. Meng!
Congratulations to Meng and Kyle for the 2016 Summer Research Award from the Chemistry Department!
Amit Pithadia obtains his Ph.D. December 11, 2015
Congratulations, Dr. Amit!
Samuel Kotler obtains his Ph.D. August 3, 2015
Congratulations, Dr. Sam!
Josh receives an NSF fellowship 2015
Congratulations, Josh!
Nirbhay Jain receives the 2015 Walter Yates Award 2015
Congratulations, Nirbhay!
Rams has been appointed as Hans Fischer Senior Fellow in the Institute for Advanced Study at Technische Universitat Munchen, Munich, Germany
Ali and Michael receive the Undergraduate Research Fellowship 2015
Congratulations, Ali and Michael!