We have successfully developed a variety of synthetic polymers that can be used to form lipid-nanodiscs. These polymer-based nanodiscs have unique advantages.
Positively-charged nanodiscs
Negatively-charged nanodiscs
Charge-free nanodiscs
Size flexibility (from ~6 to ~60 nm diameter size)
Tolerant to divalent metal ions (up to ~200 mM)
Tolerant to pH (~2 to ~10)
Easy preparation of nanodiscs
Align in the presence of an external magnetic field
100% "Detergent-free" extraction of membrane proteins
Solution NMR applications
Solid-state NMR applications
Residual dipolar-coupling based NMR applications
Commercial applications & Patents