Nanodiscs

We have successfully developed a variety of synthetic polymers that can be used to form lipid-nanodiscs. These polymer-based nanodiscs have unique advantages.

• Positively-charged nanodiscs

• Negatively-charged nanodiscs

• Charge-free nanodiscs

• Size flexibility (from ~6 to ~60 nm diameter size)

• Tolerant to divalent metal ions (up to ~200 mM)

• Tolerant to pH (~2 to ~10)

• Easy preparation of nanodiscs

• Align in the presence of an external magnetic field

• Direct "detergent-free" extraction of membrane proteins

• Solution NMR applications

• Solid-state NMR applications

• Residual dipolar-coupling based NMR applications

• Commercial applications & Patents