Publications
https://scholar.google.com/citations?user=ptJ33EMAAAAJ&hl=en&oi=ao
US Patents
A Ramamoorthy, T Ravula, Nanodisc forming Inulin based Non-ionic Polymers, US Patent (filed, 2021).
A Ramamoorthy, T Ravula, NZ Hardin, Lipid nanodisc formation by polymers having a pendant hydrophobic group, US Patent App. 16/893,772 (2020).
A Ramamoorthy, T Ravula, B Sahoo, K Yasuhara, J Arakida, J Kikuchi, Lipid Nanodisc formation by Acryloyl-based copolymers, US Patent App. 16/386,804 (2019).
A Ramamoorthy, T Ravula, NZ Hardin, SJ Cox, Polymer-Based Lipid Nanodiscs And Macrodiscs, US Patent App. 16/198,397 (2019).
2022
Nishiyama, Yusuke; Hou, Guangjin; Agarwal, Vipin; Su, Yongchao; Ramamoorthy, Ayyalusamy. Ultrafast Magic Angle Spinning Solid-State NMR Spectroscopy: Advances in Methodology and Applications. Chemical Reviews (in press).
Samuel D. McCalpin, Riqiang Fu, Thirupathi Ravula, Gang Wu, Ayyalusamy Ramamoorthy, "Magnetically Aligned Nanodiscs Enable Direct Measurement of 17O Residual Quadrupolar Coupling for Small Molecules", J. Magn. Reson. 2022, 346, 107341.
Krishnarjuna B, Thirupathi Ravula, Edgar M. Faison, Marco Tonelli, Qi Zhang, and Ayyalusamy Ramamoorthy, "Polymer-nanodiscs as a novel alignment medium for high-resolution NMR-based structural studies of nucleic acids " Biomolecules 2022, 12(11), 1628.
Arghya Chakravorty, Samuel D. McCalpin, Bikash R. Sahoo, Ayyalusamy Ramamoorthy*, Charles L. Brooks III*, "A role for free gangliosides on amyloid-beta aggregation", J. Phys. Chem. Lett. 13, 9309-9308 (2022). doi: 10.1021/acs.jpclett.2c02362.
Krishnarjuna B, Im SC, Ravula T, Marte J, Auchus RJ, and Ramamoorthy A. Non-ionic inulin-based polymer-nanodiscs enable functional reconstitution of a redox complex composed of oppositely charged CYP450 and CPR in a lipid bilayer membrane. ACS Anal. Chem. 94, 11908-11915.
Klug YA, Schwarzer R, Ravula T, Rotem E, Ramamoorthy A, Shai Y. Structural and Mechanistic Evidence for Calcium Interacting Sites in the HIV Transmembrane Protein gp41 Involved in Membrane Fusion. Biochemistry (2022); doi: 10.1021/acs.biochem.2c00372.
Krishnarjuna B, and Ramamoorthy A. "Detergent-free isolation of membrane proteins and strategies to study them in a near-native membrane environment." Biomolecules; 12, 1076 (2022). doi: 10.3390/biom12081076.
Krishnarjuna B, Ravula T, and Ramamoorthy A. "Detergent-free isolation of CYP450-reductase’s FMN-binding domain in E.coli lipid-nanodiscs using a charge-free polymer." Chemical Communications 58, 4913-4916 (2022).
"Saponins Form Nonionic Lipid Nanodiscs for Protein Structural Studies by Nuclear Magnetic Resonance Spectroscopy"
Samuel D. McCalpin, Thirupathi Ravula, and Ayyalusamy Ramamoorthy,
J. Phys. Chem. Letters (in press, 2022).
Munukutla S, Bertoy A, Rush S, Ramamoorthy A. "Molecular Music: A Modern Accompaniment to NMR Pedagogy." Journal of Chemical Education (2022).
Ravula T, Ramamoorthy A. "Measurement of Residual Dipolar Couplings Using Magnetically Aligned and Flipped Nanodiscs." Langmuir 38(1):244-252 (2022).
Sahoo BR, Souders CL 2nd, Watanabe-Nakayama T, Deng Z, Linton H, Suladze S, Ivanova MI, Reif B, Ando T, Martyniuk CJ, Ramamoorthy A. "Conformational Tuning of Amylin by Charged Styrene-Maleic-Acid Copolymers." J Mol Biol. 434(2):167385 (2022).
2021
Ramamoorthy A. "Lipids on the pathomechanisms of amyloid diseases." Chem Phys Lipids 239:105122 (2021).
Krishnarjuna B, Ivanova M, Ramamoorthy A (2021) Aggregation and the intrinsic structural disorder of dipeptide repeat peptides of C9orf72-related amyotrophic lateral sclerosis and frontotemporal dementia characterized by NMR. J. Phys. Chem B 125, 12446-12456. (special issue: 125 years of The Journal of Physical Chemistry).
Ravula et al. "Synthesis, Characterization, and Nanodisc formation of Non-ionic Polymers", Angew.Chem. 60(31):16885-16888 (2021).
Ravula et al. "A Solid-State NMR Study to Probe the Effects of Divalent Metal Ions (Ca2+ and Mg2+) on the Magnetic-Alignment of Polymer Based Lipid‐Nanodiscs", Langmuir 37(25):7780-7788 (2021).
Krishnarjuna et al. "Nanodisc reconstitution of flavin mononucleotide binding domain of cytochrome-P450-reductase enables high-resolution NMR probing", Chemical Communications 57(39):4819-4822 (2021).
Bera et al. "Solid-state packing dictates the unexpected solubility of aromatic peptides", Cell Reports Physical Science 2(4):100391 (2021).
Sahoo et al. "Degradation of Alzheimer’s amyloid-β by a catalytically inactive insulin-degrading enzyme", Journal of Molecular Biology 433(13):166993 (2021).
Lucie Khemtemourian, Federico Antoniciello, Bikash R. Sahoo, Marion Decossas, Sophie Lecomtea and Ayyalusamy Ramamoorthy, "Investigation of the effects of two major secretory granules components, insulin and zinc, on human-IAPP amyloid aggregation and membrane damage", Chemistry and Physics of Lipids 237:105083 (2021).
Di Mauro, Giacomo; La Rosa, Carmelo; Condorelli, Marcello; Ramamoorthy, Ayyalusamy, "Benchmarks of SMA-copolymer derivatives and nanodiscs integrity", Langmuir 37(10):3113-3121 (2021).
Nguyen, Phuong; Ramamoorthy, Ayyalusamy; Sahoo, Bikash; Zheng, Jie; Chiricotto, Mara; Straub, John; Domínguez, Laura; Shea, Joan-Emma; Dokholyan, Nikolay; De Simone, Alfonso; Ma, Buyong; Nussinov, Ruth; Najafi, Saeed; McCarty, James; Loquet, Antoine; Faller, Peter; Ganguly, Pritam; Ngo, Son Tung; Li, Mai Suan; Hall, Carol; Wang, Yiming; Miller, Yifat; Melchionna, Simone; Habenstein, Birgit; Timr, Stepan; Chen, Jiaxing; Hnath, Brianna; Strodel, Birgit; Kayed, Rakez; Lesne, Sylvain; Wei, Guanghong; Sterpone, Fabio; Doig, Andrew; Derreumaux, Philippe, "Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer’s Disease, Parkinson’s Disease, Type II Diabetes and Amyotrophic Lateral Sclerosis", Chemical Reviews 121(4):2545-2647 (2021).
Danilo Milardi, Ehud Gazit, Sheena E. Radford, Yong Xu, Rodrigo U. Gallardo, Amedeo Caflisch, Gunilla T. Westermark, Per Westermark, Carmelo La Rosa, and Ayyalusamy Ramamoorthy, "Proteostasis of Islet Amyloid Polypeptide: A Molecular Perspective of Risk Factors and Protective Strategies for Type II Diabetes",
Chemical Reviews Feb 10;121(3):1845-1893 (2021).
MI Ivanova, Y Lin, YH Lee, J Zheng, A Ramamoorthy, Biophysical processes underlying cross-seeding in amyloid aggregation and implications in amyloid pathology, Biophysical Chemistry, 269:106507 (2021).
2020
(333) Michele F Sciacca, Fabio Lolicato, Carmelo Tempra, Federica Scollo, Bikash R Sahoo, Matthew D Watson, Sara García-Viñuales, Danilo Milardi, Antonio Raudino, Jennifer C Lee, Ayyalusamy Ramamoorthy, Carmelo La Rosa, Lipid-Chaperone Hypothesis: A Common Molecular Mechanism of Membrane Disruption by Intrinsically Disordered Proteins, ACS Chem. Neurosci. 2020, 11, 24, 4336.
(332) Ravula T., Sahoo BR., Dai X., Ramamoorthy A., Natural-abundance 17O NMR spectroscopy of magnetically aligned lipid nanodiscs, Chemical Communications, 2020 . Link
(331) Bharadwaj P., Solomon T., Sahoo BR., Ignasiak K., Gaskin S., Rowles J., Verdile G., Howard M., Bond C., Ramamoorthy A., Martins R., Newsholme P., Amylin and beta amyloid proteins interact to form amorphous heterocomplexes with enhanced toxicity in neuronal cells, Scientific Reports, 10, 1, 1-14, (2020), Link
(330) Cox S., Lam B., Prasad A., Marietta H., Stander N., Joel J., Sahoo BR., Guo F., Stoddard A., Ivanova M., Ramamoorthy A., High-troughput screening at the membrane interface reveals inhibitors of amyloid-β, Biochemistry, 59, 24, 2249-2258, (2020), Link
(329) Di Mauro G., Hardin N., Ramamoorthy A., Lipid-nanodiscs formed by paramagnetic metal chelated polymer for fast NMR data acquisition, (BBA)-Biomembranes, 183332 (2020), Link
(328) Bai J., Wang J., Ravula T., Im S., Anantharamaiah G., Waskell L., Ramamoorthy A., Expression, purification, and functional reconstitution of 19F-labeled cytochrome b5 in peptide nanodiscs for NMR studies, (BBA) - Biomembranes, 1862, 5, 183194, (2020), Link
(327) Zhang R., Hong Y., Ravula T., Nishiyama Y., Ramamoorthy A., High-resolution proton-detected MAS experiments on self-assembled diphenylalanine nanotubes enabled by fast MAS and high magnetic field, Journal of Magnetic Resonance, 106717 (2020), Link
(326) La Rosa C., Condorelli M., Compagnini G., Lolicato F., Milardi D., Do T., Kartunen M., Pannuzzo M., Ramamoorthy A., Fraternali F., Collu F., Rezaei H., Strodel B., Raudino A., Symmetry-breaking transitions in the early steps of protein self-assembly, European Biophysics Journal, 1-17, (2020), Link
(325) Chakraborty P., Tang Y., Yamamoto T., Yao Y., Guterman T., Zilberzwige-Tal S., Adadi N., Ji W., Dvir T., Ramamoorthy A., Wei G., Gazit E., Unusual two-step assembly of a minimalistic dipeptide-based functional hypergelator, Advanced Materials 32 (9), 1906043, (2020), Link
(324) Sahoo B., Bekier II M., Liu Z., Kocman V., Stoddard A., Anantharamaiah G., Nowick J., Fierke C., Wang Y., Ramamoorthy A., Structural Interaction of Apolipoprotein AI Mimetic Peptide with Amyloid-β Generates Toxic Hetero-oligomers, Journal of Molecular Biology 432 (4), 1020-1034, (2020), Link
(323) Ravula T., Kim J., Lee D., Ramamoorthy A., Magnetic alignment of polymer nanodiscs probed by solid-state NMR spectroscopy, Langmuir 36 (5), 1258-1265, (2020), Link
(322) Watanabe-Nakayama T., Sahoo B., Ramamoorthy A., Ono K., High-speed atomic force microscopy reveals the structural dynamics of the amyloid-β and amylin aggregation pathways, International journal of molecular sciences, 21 (12), 4287, (2020), Link
(321) Krishnarjuna B., Ravula T., Ramamoorthy A., Detergent free extraction, reconstitution and characterization of membrane-anchored cytochrome-b5 in native lipids, Chemical Communications, 56, 6511-6514, (2020), Link
(320) Sahoo B., Liang W., Tang W., Ramamoorthy A., Degradation of Alzheimers Amyloid-beta by a catalytically inactive insulin degrading enzyme, bioRxiv, (2020), Link
(319) Sahoo B., Souders C., Ivanova M., Deng Z., Nakayama T., Suladze S., Reif B., Ando T., Martyniuk C., Ramamoorthy A., Conformational tuning of amylin by charged SMA copolymers, (2020), bioRxiv, Link
(318) Sahoo B., Cox S., Ramamoorthy A., High-resolution probing of early events in amyloid-β aggregation related to Alzheimer's disease, Chemical Communications 56 (34), 4627-4639 (2020), Link
2019
(317) R Zhang, Y Nishiyama, A Ramamoorthy, Exploiting heterogeneous time scale of dynamics to enhance 2D HETCOR solid-state NMR sensitivity, Journal of Magnetic Resonance 309, 106615
(316) Hardin N., Kocman V., Di Mauro G.M., Ravula T., Ramamoorthy A., Metal-Chelated Polymer Nanodiscs for NMR Studies, Angewandte Chemie International Edition, Link
(315) Kocman V., Di Mauro G.M., Veglia G., Ramamoorthy A., Use of paramagnetic systems to speed-up NMR data acquisition and for structural and dynamic studies, Solid State Nuclear Magnetic Resonance 102 (2019) 36-46 Link
(314) Ravula T., Ramamoorthy A., Magnetic Alignment of Polymer Macro-Nanodiscs Enables Residual-Dipolar-Coupling-Based High-Resolution Structural Studies by NMR Spectroscopy, Angewandte Chemie International Edition, Link
(313) Lin Y, Sahoo BR, Ozawa D, Kinoshita M, Kang J, Lim MH, Okumura M, Huh YH, Moon E, Jang JH, Lee HJ, Ryu KY, Ham S, Won HS, Ryu KS, Sugiki T, Bang JK, Hoe HS, Fujiwara T, Ramamoorthy A, Lee YH., Diverse Structural Conversion and Aggregation Pathways of Alzheimer's Amyloid-β (1-40). ACS Nano 2019 - Link
(312) Sahoo B.R., Genjo T., Moharana K., Ramamoorthy A. Self-assembly of polymer-encased lipid nanodiscs and membrane protein reconstitution. Journal of Physical Chemistry B. 123, 2: 4562-4570 - Link
(311) N MacKinnon, W Ge, P Han, J Siddiqui, JT Wei, T Raghunathan, ..., NMR-based metabolomic profiling of urine: Evaluation for application in prostate cancer detection, Natural Product Communications 14 (5), 1934578X19849978
(310) YH Lee, Y Lin, SJ Cox, M Kinoshita, BR Sahoo, M Ivanova, ..., Zinc boosts EGCG's hIAPP amyloid Inhibition both in solution and membrane, Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1867 (5), 529-536
(309) Ravula T., Hardin N.Z., Ramamoorthy A. Polymer Nanodiscs: Advantages and Limitations. Chemistry and Physics of Lipids - Link
(308) Hardin N.Z., Ravula T., Di Mauro G.D., Ramamoorthy A. Hydrophobic Functionalization of Polyacrylic Acid as a Versatile Platform for the Development of Polymer Lipid Nanodisks. Small. e1804813. doi:10.1002/smll.201804813 - Link
(307) Pandey M.K., Damron J.T., Ramamoorthy A., Nishiyama Y. Proton-detected 3D 1H anisotropic/14N/1H isotropic chemical shifts correlation NMR under fast magic angle spinning on solid samples without isotopic enrichment. Solid State Nuclear Magnetic Resonance 97:40-45 - Link
(306) KA Gentry, GM Anantharamaiah, A Ramamoorthy, Probing protein–protein and protein–substrate interactions in the dynamic membrane-associated ternary complex of cytochromes P450, b 5, and reductase,
Chemical Communications 55 (89), 13422-13425
(305) JR Brender, A Ghosh, SA Kotler, J Krishnamoorthy, S Bera, V Morris, ..., Probing transient non-native states in amyloid beta fiber elongation by NMR, Chemical Communications 55 (31), 4483-4486
(304) M Mahajan, T Ravula, E Prade, GM Anantharamaiah, A Ramamoorthy, Probing membrane enhanced protein–protein interactions in a minimal redox complex of cytochrome-P450 and P450-reductase, Chemical Communications 55 (41), 5777-5780
(303) Sahoo B.R., Genjo T., Watanabe-Nakayama T., Stoddard A., Ando T., Yasuhara K., Fierke C.A., Ramamoorthy A. Cationic polymethacrylate-copolymer acts as an agonist for beta-amyloid and antagonist for amylin fibrillation. Chemical Science 10(14):3976-3986 - Link
2018
(302) A Naito, N Matsumori, A Ramamoorthy, Dynamic membrane interactions of antibacterial and antifungal biomolecules, and amyloid peptides, revealed by solid-state NMR spectroscopy, Biochimica et Biophysica Acta (BBA)-General Subjects 1862 (2), 307-323
(301) Sahoo BR., Genjo T., Bekier M., Cox SJ., Stoddard AK., Ivanova M., Yasuhara K., Fierke CA., Wang Y., Ramamoorthy A., Alzheimer's amyloid-beta intermediates generated using polymer-nanodiscs, Chem. Commun. 54, 12883-12886 . (2018) Link
(300) Barnaba C., Ravula T., Medina-Meza I.G., Im S.C., Anantharamaiah G.M., Waskell L., Ramamoorthy A. Lipid-exchange in nanodiscs discloses membrane boundaries of cytochrome-P450 reductase. Chem. Commun. 54, 6336-6339. (2018) Link
(299) Gentry K.A., Zhang M., Im S.C., Waskell L., Ramamoorthy A. Substrate Mediated Redox Partner Selectivity of Cytochrome P450. Chem. Commun. 54(45):5780-5783. (2018) Link
(298) Kotler S.A., Ramamoorthy A. Preparation of Stable Amyloid-B Oligomers Without Perturbative Methods. Peptide Self-Assembly (Humana Press, New York, NY), 1777:331-338. (2018) Link.
(297) Rodriguez Camargo D.C., Garg D., Buday K., Franko A., Rodriguez Camargo A., Schmidt F., Cox S.J., Suladze S., Haselbeck M., Mideksa Y.G., Gemmecker G., Aichler M., Mettenleiter G., Schulz M., Walch A.K., Hrabe de Angelis M., Feige M.J., Sierra C.A., Conrad M., Tripsianes K., Ramamoorthy A., Reif B. hIAPP forms toxic oligomers in plasma. Chem. Commun. 54(43):5426-5429. (2018) Link
(296) Ravula T., Ishikuro, D., Kodera N., Ando T., Anantharamaiah G.M., Ramamoorthy A. Real-Time Monitoring of Lipid Exchange via Fusion of Peptide Based Lipid-Nanodiscs. Chem. Mater. 30(10):3204-3207. (2018) Link
(295) Damron J.T., Ma J., Kurz R., Saalwachter K., Matzger A.J., Ramamoorthy A. The Influence of Chemical Modification on Linker Rotational Dynamics in Metal-Organic Frameworks. Angew. Chem. Int. Ed. Engl. 57(28):8678-8681. (2018) Link
(294) Ravula T., Hardin N.Z., Bai J., Im S.C., Waskell L., Ramamoorthy A. Effect of polymer charge on functional reconstitution of membrane proteins in polymer nanodiscs. Chem. Commun. 54, 9615-9618. (2018) Link
(293) Ravula T., Hardin N.Z., Di Mauro G.M., Ramamoorthy A. Styrene maleic acid derivates to enhance the applications of bio-inspired polymer based lipid-nanodiscs. European Polymer Journal 108:597-602. (2018) Link
(292) Barnaba C., Ramamoorthy A. Picturing the Membrane-assisted Choreography of Cytochrome P450 with Lipid Nanodiscs. Chem. Phys. Chem. 19(20):2603-2613. (2018) Link
(291) Lee Y.H., Lin Y., Cox S.J., Kinoshita M., Sahoo B.R., Ivanova M., Ramamoorthy A: Zinc boosts EGCG's hIAPP amyloid inhibition both in solution and membrane. Biochim. Biophys. Acta Proteins Proteom. (2018) Link
(290) Sahoo B.R., Genjo T., Cox S.J., Stoddard A.K., Anantharamaiah G.M., Fierke C., Ramamoorthy A: Nanodisc-forming scaffold protein promoted retardation of amyloid-beta aggregation. J Mol. Biol. 430(21):4230-4244. (2018) Link
(289) Prade E., Mahajan M., Im S.C., Zhang M., Gentry K. A., Anantharamaiah G. M., Waskell L., Ramamoorthy A. A Minimal Functional Complex of Cytochrome P450 and FBD of Cytochrome P450 Reductase in Nanodiscs. Angew. Chem. Int. Ed. Engl. (2018) Link
(288) Terakawa M. S., Lin Y., Kinoshita M., Kanemura S., Itoh D., Sugiki T., Okumura M., Ramamoorthy A., Lee Y. H. Impact of membrane curvature on amyloid aggregation. Biochim. Biophys. Acta. (2018) Link
(287) Louka A., Matlahov I., Giuntini S., Cerofolini L., Cavallo A., Pillozzi S., Ravera E., Fragai M., Arcangeli A., Ramamoorthy A., Goobes G., Luchinat C. Engineering I-asparaginase for spontaneous formation of calcium phosphate bioinspired microreactors. Phys. Chem. Chem. Phys. 20(18):12719-12726. (2018) Link
(286) Sciacca M. F. M., Chillemi R., Sciuto S., Greco V., Messineo C., Kotler S. A., Lee D. K., Brender J. R., Ramamoorthy A., La Rosa C., Milardi D. A blend of two resveratrol derivatives abolishes hIAPP amyloid growth and membrane damage. Biochim. Biophys. Acta. (2018) Link
(285) Lee Y. H., Ramamoorthy A. Semen-derived amyloidogenic peptides-Key players of HIV infection. Protein Sci. (2018) Link
(284) Barnaba C., Sahoo B. R., Ravula T., Medina-Meza I. G., Im S.C., Anantharamaiah G. M., Waskell L., Ramamoorthy A. Cytochrome-P450-Induced Ordering of Microsomal Membranes Modulates Affinity for Drugs. Angew. Chem. Int. Ed. Engl. 57(13):3391-3395. (2018) Link
(283) Wang J., Yamamoto T., Bai J., Cox S. J., Korshavn K. J., Monette M., Ramamoorthy A. Real-time monitoring of the aggregation of Alzheimer's amyloid-B via 1H magic angle spinning NMR spectroscopy. Chem. Commun. 54(16):2000-2003. (2018) Link
(282) Zhou Y., Damasceno P. F., Somashekar B.S., Engel M., Tian F., Zhu J., Huang R., Johnson K., McIntyre C., Sun K., Yang M., Green P. F., Ramamoorthy A., Glotzer S. C., Kotov N. A. Unusual multiscale mechanics of biomimetic nanoparticle hydrogels. Nat. Commun. 9(1):181 (2018). Link
(281) Ravula T., Hardin N. Z., Ramadugu S. K., Cox S. J., Ramamoorthy A. Formation of pH-Resistant Monodispersed Polymer-Lipid Nanodiscs. Angew. Chem. Int. Ed. Engl. 7(1):34-41 (2018). Link
(280) R Zhang, KH Mroue, P Sun, A Ramamoorthy, High-resolution proton NMR spectroscopy of polymers and biological solids, Modern Magnetic Resonance.
2017
(279) Rodriguez Camargo D. C., Korshavn K. J., Jussupow A., Raltchev K., Goricanec D., Fleisch M., Sarkar R., Xue K., Aichler M., Mettenleiter G., Walch A. K., Camilloni C., Hagn F., Reif B., Ramamoorthy A. Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediate. Elife. 6 (2017). Link
(278) Yasuhara K., Arakida J., Ravula T., Ramadugu S. K., Sahoo B., Kikuchi J. I., Ramamoorthy A. Spontaneous Lipid Nanodiscs Formation by Amphiphilic Polymethacrylate Copolymers. J. Am. Chem. Soc. (2017) Link
(277) Ravula T., Barnaba C., Mahajan M., Anantharamaiah G. M., Im S.C., Waskell L., Ramamoorthy A. Membrane environment drives cytochrome P450's spin transition and its interaction with cytochrome b5. Chem. Commun. (Camb). 53(95):12798-12801. (2017). Link
(276) Beck M. W., Derrick J. S., Suh J. M., Kim M., Korshavn K. J., Kerr R. A., Cho W. J., Larsen S. D., Ruotolo B. T., Ramamoorthy A., Lim M. H. Minor Structural Variations of Small Molecules Tune Regulatory Activities toward Pathological Factors in Alzheimer's Disease. Chem. Med. Chem. 12(22):1828-1838 (2017). Link
(275) Jones M. R., Mathieu E., Dyrager C., Faissner S., Vaillancourt Z., Korshavn K. J., Lim M. H., Ramamoorthy A., Wee Yong V., Tsutsui S., Stys P. K., Storr T. Multi-target-directed phenol-triazole ligands as therapeutic agents for Alzheimer's disease. Chem. Sci. 8(8):5636-5643. (2017). Link
(273) Ravula T., Hardin N. Z., Ramadugu S. K., Ramamoorthy A. pH Tunable and Divalent Metal Ion Tolerant Polymer Lipid Nanodiscs. Langmuir. 33(40):10655-10662. (2017). Link
(272) Damron J. T., Kersten K. M., Pandey M. K., Mroue K. H., Yarava J. R., Nishiyama Y., Matzger A. J., Ramamoorthy A. Electrostatic Constraints Assessed by 1H MAS NMR Illuminate Differences in Crystalline Polymorphs. J. Phys. Chem. Lett. 8(17):4253-5257. (2017). Link
(271) Gentry K., Prade E., Barnaba C., Zhang M., Mahajan M., Im S.C., Anantharamaiah G. M., Nagao S., Waskell L., Ramamoorthy A. Kinetic and Structural Characterization of the Effects of Membrane on the Complex of Cytochrome b5 and Cytochrome c. Scientific Reports. 7:7793 (2017). Link
(270) Kamgar-Parsi K., Hong L., Naito A., Brooks C. L. 3rd, Ramamoorthy A. Growth-incompetent monomers of human calcitonin lead to a non-canonical direct relationship between peptide concentration and lag time. J. Biol. Chem. (2017) Link
(269) Ravula T., Ramadugu S. K., Di Mauro G., Ramamoorthy A. Bioinspired, Size-Tunable Self-Assembly of Polymer-Lipid Bilayer Nanodiscs. Angew. Chem. Int. Ed. Engl. (2017). Link
(268) Yamamoto K., Caporini M. A., Im S.C., Waskell L., Ramamoorthy A. Transmembrane Interactions of Full-length Mammalian Bitopic Cytochrome-P450-Cytochrome-b5 Complex in Lipid Bilayers Revealed by Sensitivity-Enhanced Dynamic Nuclear Polarization Solid-state NMR Spectroscopy. Sci. Rep. 7(1):4116 (2017) Link
(267) Mukherjee S., Kar R. K., Nanga R. P. R., Mroue K. H., Ramamoorthy A. Bhunia A. Phys. Chem. Chem. Phys. 19(29):19289-19299. (2017) Link
(266) Kinoshita M., Kakimoto E., Terakawa M. S., Lin Y., Ikenoue T., So M., Sugiki T., Ramamoorthy A., Goto Y., Lee Y. H. Model Membrane size-dependent amyloidogenesis of Alzheimer's amyloid-B peptides. Phys. Chem. Chem. Phys. 19(24):16257-16266. (2017) Link
(265) Naito A., Matsumori N., Ramamoorthy A. Dynamic membrane interactions of antibacterial and antifungal biomolecules, and amyloid peptides, revealed by solid-state NMR spectroscopy. Biochim. Biophys. Acta. S0304-4165(17):30190-3. (2017) Link
(264) Zhang R., Duong N. T., Nishiyama Y., Ramamoorthy A. 3D Double-Quantum/Double-Quantum Exchange Spectroscopy of Protons Under 100 kHz Magic Angle Spinning. J. Phys. Chem. B (2017)
(263) Tian D., Li T., Zhang R., Wu Q., Chen T., Sun P., Ramamoorthy A. Conformations and Intermolecular Interactions in Cellulose/Silk Fibroin Blend Films: A Solid-State NMR Perspective. J. Phys. Chem. B (2017)
(262) Zhang R., Mroue K. H., Sun P., Ramamoorthy A. High-Resolution Proton NMR Spectroscopy of Polymers and Biological Solids. Modern Magnetic Resonance (2017).
(261) Naito A., Matsumori N., Ramamoorthy A. Dynamic membrane interactions of antibacterial and antifungal biomoelcules, and amyloid peptides, revealed by solid-state NMR spectroscopy. BBA Biomembranes (in presss)
(260) Mroue K. H., Viswan A., Sinha N., Ramamoorthy A. Solid-State NMR Spectroscopy: The Magic Wand to View Bone at Nanoscopic Resolution. Ann. Rep. NMR Spectroscopy (in press).
(259) Kinoshita M., Kakimoto E., Terakawa M. S., Lin Y., Ikenoue T., So M., Sugiki T., Ramamoorthy A., Goto Y., Lee Y-H. Model membrane size-dependent amyloidogenesis of Alzheimer's amyloid-beta peptides. Phys. Chem. Chem. Phys. (in press).
(258) Barnaba C., Gentry K., Sumangala N., Ramamoorthy A. The catalytic function of cytochrome P450 is entwined with its membrane-bound nature. F1000Research2017, 6(F1000 Faculty Rev):662. Link
(257) Zhang R., Mroue K., Ramamoorthy A. Proton-Based Ultrafast Magic Angle Spinning Solid-State NMR Spectroscopy. Accounts of Chemical Research. (2017) (in press)
(256) Korshavn K. J., Satriano C., Lin Y., Zhang R., Dulchavsky M., Bhunia A., Ivanova M. I., Lee Y. H., La Rosa C., Lim M. H., Ramamoorthy A. Reduced Lipid Bilayer Thickness Regulates the Aggregation and Cytotoxicity of Amyloid-B. J. Biol. Chem. (2017) 292(11)4638-4650. Link
(255) Lee H. J., Korshavn K., Nam Y., Kang J., Paul T., Kerr R., Yoon I. S., Ozbil M., Kim K. S., Ruotolo B., Prabhakar R., Ramamoorthy A., Lim M. H. Structural and Mechanistic Insights into Development of Chemical Tools to Control Individual and Inter-related Pathological Features in Alzheimer's Disease. Chemistry (2016). Link
(254) Kang J., Lee S. J., Nam J.S., Lee H. J., Kang M. G., Korshavn K. J., Kim H. T., Cho J., Ramamoorthy A., Rhee H. W., Kwon T. H., Lim M. H. An Iridium (III) Complex as a Photoactivatable Tool for Oxidation of Amyloidgenic Peptides with Subsequent Modulation of Peptide Aggregation. Chemistry (2016). Link
2016
(253) Kamgar-Parsi K., Tolchard J., Habenstein B., Loquet A., Naito A., Ramamoorthy A. Structural Biology of Calcitonin: From Aqueous Therapeutic Properties to Amyloid Aggregation. Isr. J. Chemistry. (In press) Link
(252) Datta A., Yadav V., Ghosh A., Choi J., Bhattacharyya D., Kar R. K., Ilyas H., Dutta A., An E., Mukhopadhyay J., Lee D., Sanyal K., Ramamoorthy A., Bhunia A. Mode of Action of a Designed Antimicrobial Peptide: High Potency against Cryptococcus neoformans. Biophys. J. (2016) 111(8):1724-1737. Link
(251) Sciacca M. F. M., Lolicato F., Di Mauro G., Milardi D., D'Urso L., Satriano C., Ramamoorthy A., La Rosa C. The Role of Cholesterol in Driving IAPP-Membrane Interactions, Biophys J. (2016) Link
(250) Mroue K. H., Xu J., Zhu P., Morris M. D., Ramamoorthy A. Selective Detection and complete identification of triglycerides in cortical bone by high-resolution (1)H MAS NMR spectroscopy. Phys. Chem. Chem. Phys. (2016) 18(28):18687-91. Link
(249) Zhang R., Chen Y., Rodriguez-Hornedo N., Ramamoorthy A. Enhancing NMR Sensitivity of Natural-Abundance Low-Gamma Nuclei by Ultrafast Magic-Angle-Spinning Solid-State NMR Spectroscopy. Chem. Phys. Chem. (2016) Link
(248) Bera S., Korshavn K. J., Kar R. K, Lim M. H., Ramamoorthy A., Bhunia A. Biophysical insights into the membrane interaction of the core amyloid-forming AB40 fragment K16-K28 and its role in the pathogenesis of Alzheimer's disease. Phys. Chem. Chem. Phys. (2016) Link
(247) Jones M. R., Dyrager C., Hoarau M., Korshavn K. J., Lim M. H., Ramamoorthy A., Storr T. Multifunctional Quinoline-triazole Derivatives as Potential Modulators of Amyloid-B Peptide Aggregation. J. Inorg. Biochem. (2016) Link
(246) Derrick J. S., Kerr R.A., Korshavn K. J., McLane M. J., Kang J., Nam E., Ramamoorthy A., Ruotolo B. T., Lim M. H. Importance of the Dimethylamino Functionality on a Multifunctional Framework for Regulating Metals, Amyloid-B, and Oxidative Stress in Alzheimer's Disease. Inorg. Chem. (2016) Link
(245) Fichman G., Guterman T., Damron J., Adler-Abramovich L., Schmidt J., Kesselman E., Shimon L.J., Ramamoorthy A., Talmon Y., Gazit E. Spontaneous Structural Transition and Crystal Formation in Minimal Supramolecular Polymer Model. Sci. Adv. (2016) 12;2(2) Link
(244) Zhang R., Mroue K., Ramamoorthy A. Hybridizing Cross-Polarization with NOE or Refocused-INEPT Enhances the Sensitivity of MAS NMR Spectroscopy. J. Magn. Reson. (2016) (In press)
(243) Zhang M., Huang R., Ackermann R., Im SC, Waskell L., Schwendeman A., Ramamoorthy A. Reconstitution of Cytb5-CytP450 Complex in Nanodiscs for Structural Studies by NMR. Angewandte Chemie. (2016) Link
(242) Pandey M. K., Yarava J. R., Zhang R., Ramamoorthy A., Nishiyama Y. Proton-detected 3D 15N/1H/1H isotropic/anisotropic/isotropic chemical shift correlation solid-state NMR at 70 kHz MAS. Solid State Nuclear Magnetic Resonance. (In press)
(241) Lee H. J., Kerr, R. A., Korshavn, K. J., Lee J., Kang J., Ramamoorthy A., Ruotolo B. T., Lim M. Effects of Hydroxyl Group Variations on a Flavonoid Backbone Toward Modulation of Metal-Free and Metal-Induced Amyloid-B Aggregation. Inorg. Chem. Front. (2016) Link
(240) Zhang R., Ramamoorthy A. Constant-time 2D and 3D through-bond correlation NMR spectroscopy of solids under 60 KHz MAS. J. Chem. Phys. J. Chem. Phys. (2016) 144: 034202. Link
2015
(233) Pandey M. K., Zhang R., Hashi K., Ohki S., Nishijima G., Matsumoto S., Noguchi T., Deguchi K., Goto A., Shimizu T., Maeda H., Takahashi M., Yanagisawa Y., Yamazaki T., Iguchi S., Tanaka R., Nemoto T., Miyamoto T., Suematsu H., Saito K., Miki T., Ramamoorthy A., Nishiyama Y. 1020 MHz single-channel proton fast magic angle spinning solid-state NMR spectroscopy. J. Magn. Reson. (2015) 261:1-5. Link
(232) Zhang R., Nishiyama Y., Ramamoorthy A. Proton-detected 3D (1)H/(13)C/(1)H correlation experiment for structural analysis in rigid solids under ultrafast-MAS above 60 kHz. J. Chem. Phys. (2015) 143(16):164201. Link
(231) Zhang R., Mroue K. H., Ramamoorthy A. Proton chemical shift tensors determined by 3D ultrafast MAS double-quantum NMR spectroscopy. J. Chem. Phys. (2015) 143(14):144201. Link
(230) Pithadia, A. S., Brender, J. R., Fierke, C. A., Ramamoorthy, A. Inhibition of IAPP Aggregation and Toxicity by Natural Products and Derivatives. J. Diabetes Res. (2015) Link
(229) Pithadia, A. S., Bhunia, A., Sribalan, R., Padmini, V., Fierke, C. A., Ramamoorthy, A. Influence of a curcumin derivative on hIAPP aggregation in the absence and presence of lipid membranes. Chem. Comm. (2015) Link
(228) Korshavn, K. J., Bhunia, A., Lim, M. H., Ramamoorthy, A. Amyloid-B Adopts a Conserved, Partially Folded Structure upon Binding to Zwitterionic Lipid Bilayers Prior to Amyloid Formation. Chem. Comm. (2015) Link
(227) Korshavn, K. J., Jang, M., Kwak, Y. J., Kochi, A., Vertuani, S., Manfredini, S., Ramamoorthy, A., Lim, M. H. Reactivity of Metal-Free and Metal-Associated Amyloid-B with Glycosylated Polyphenols and Their Esterified Derivatives. Sci. Rep. (2015) Link
(226) Derrick, J.S., Kerr, R., Nam, Y., Oh, S. B., Lee, H. J., Earnest, K. G., Suh, N., Peck, K. L., Ozbil, M., Korshavn, K. J., Ramamoorthy, A., Prabhakar, R., Merino, E. J., Shearer, J., Ruotolo, B., Lim, M. H. Covalent Link of a Redox-Active, Compact Molecule for the Crosslinking of Amyloidogenic Peptides into Nontoxic, Off-pathway Aggregates. J. Am. Chem. Soc. (2015) 137(46):14785-14797. Link
(225) Zhang R, Ramamoorthy A. Dynamics-based selective 2D (1)H/(1)H chemical shift correlation spectroscopy under ultrafast MAS conditions. J Chem Phys. (2015) 142(20):204201.Link
(224) Jain N. S., Durr U. H. N., Ramamoorthy A. Bioanalytical methods for metabolomic profiling: Detection of head and neck cancer, including oral cancer. Chinese Chemical Letters. (2015) 26:407-415. Link
(223) Zhang R, Ramamoorthy A. Selective excitation enables assignment of proton resonances and (1)H-(1)H distance measurement in ultrafast magic angle spinning solid state NMR spectroscopy. J Chem Phys. (2015) 143(3):034201. Link
(222) Mroue KH, Nishiyama Y, Kumar Pandey M, Gong B, McNerny E, Kohn DH, Morris MD, Ramamoorthy A. Proton-Detected Solid-State NMR Spectroscopy of Bone with Ultrafast Magic Angle Spinning. Sci. Rep. (2015) 5:11991. Link
(221) Datta A, Ghosh A, Airoldi C, Sperandeo P, Mroue KH, Jimenez-Barbero J, Kundu P, Ramamoorthy A, Bhunia A. Antimicrobial Peptides: Insights into Membrane Permeabilization, Lipopolysaccharide Fragmentation and Application in Plant Disease Control. Sci. Rep. (2015) 5:11951. Link
(220) Kotler SA, Brender JR, Vivekanandan S, Suzuki Y, Yamamoto K, Monette M, Krishnamoorthy J, Walsh P, Cauble M, Holl MM, Marsh EN, Ramamoorthy A. High-resolution NMR characterization of low abundance oligomers of amyloid-beta without purification. Sci. Rep. (2015) 5:11811. Link
(219) Zhang R, Pandey MK, Nishiyama Y, Ramamoorthy A. A Novel High-Resolution and Sensitivity-Enhanced Three-Dimensional Solid-State NMR Experiment Under Ultrafast Magic Angle Spinning Conditions. Sci. Rep. (2015) 5:11810. Link
(218) Kamarajan P, Hayami T, Matte B, Liu Y, Danciu T, Ramamoorthy A, Worden F, Kapila S, Kapila Y. Nisin ZP, a Bacteriocin and Food Preservative, Inhibits Head and Neck Cancer Tumorigenesis and Prolongs Survival. PLoS One. (2015) 10(7):e0131008. Link
(217) Zhang M, Huang R, Im SC, Waskell L, Ramamoorthy A. Effects of membrane mimetics on cytochrome P450-cytochrome b5 interactions characterized by NMR spectroscopy. J. Biol. Chem. (2015) 290(20):12705-18. Link
(216) Ghosh A, Pithadia AS, Bhat J, Bera S, Midya A, Fierke CA, Ramamoorthy A, Bhunia A. Self-assembly of a nine-residue amyloid-forming peptide fragment of SARS corona virus E-protein: mechanism of self aggregation and amyloid-inhibition of hIAPP. Biochemistry. (2015) 54(13):2249-61. Link
(215) Brender JR, Krishnamoorthy J, Sciacca MF, Vivekanandan S, D'Urso L, Chen J, La Rosa C, Ramamoorthy A. Probing the sources of the apparent irreproducibility of amyloid formation: drastic changes in kinetics and a switch in mechanism due to micellelike oligomer formation at critical concentrations of IAPP. J Phys Chem B. (2015) 119: 2886-96. Link
(214) Soblosky L, Ramamoorthy A, Chen Z. Membrane interaction of antimicrobial peptide using E.coli lipid extract as model bacterial cell membranes and SFG spectroscopy. Chem. Phys. Lipids. (in press) Link
(213) Lee D, Bhunia A, Kotler SA, Ramamoorthy A. Detergent-type membrane fragmentation by MSI-78, MSI-367, MSI-594, and MSI-843 antimicrobial peptides, and inhibition by cholesterol: a solid-state NMR study. Biochemistry (in press) Link
(212) Zhang M, Le Clair SV, Huang R, Ahuja S, Im SC, Waskell L, Ramamoorthy A. Insights into the role of substrates on the interaction between cytochrome b5 and cytochrome P450 2B4 by NMR. Sci. Rep. (Nature) (2015) 5:8392 Link
(211) Zhang R, Nishiyama Y, Sun P, Ramamoorthy A, Phase cycling schemes for finite-pulse-RFDR MAS solid-state NMR experiments. J. Magn. Reson. 252 (2015): 55-66 Link
(210) Huang R, Zhang M, Rwere F, Waskell L, Ramamoorthy A. Kinetic and structural characterization of the intraction between the FMN binding domain of Cytochrome P450 reductase and cytochrome c. J. Biol. Chem. (in press) Link
(209) Yamamoto K, Pearcy P, Lee D, Yu C, Im SC, Waskell L, Ramamoorthy A. Temperature-resistant bicelles for structural studies by solid-state NMR spectroscopy. Langmuir. 31 (2015): 1496-1504 Link
(208) Chattah AK, Zhang R, Mroue KH, Pfund LY, Longhi MR, Ramamoorthy A. Investigating albendazole desmotropes by solid-state NMR spectroscopy. Mol Pharm (in press) Link
(207) Zhang R., Damron J., Vosegaard T., Ramamoorhty A. A cross-polarization based rotating-frame separated-local-field NMR experiment under ultrafast MAS conditions. J. Magn. Reson. 250 (2015): 37-44 Link
(206) Pandey M., Malon M., Ramamoorthy A., Nishiyama Y., Composite-180o pulse-based symmetry sequences to recouple proton Chemical Shift Anisotropy tensors under ultrafast MAS solid-state NMR spectroscopy. J. Magn. Reson. 250 (2015): 45-54 Link
(205) Yamamoto K., Caporini MA., Im SC., Waskell L., Ramamoorthy A. Cellular solid-state NMR investigation of a membrane protein using dynamic nuclear polarization. Biochim Biophys Acta. 1848 (2015): 342-349 Link
(204) Sudheendra US., Dhople V., Datta A., Kar RK., Shelburne CE., Bhunia A., Ramamoorthy A. Membrane disruptive antimicrobial activities of human β-defensin-3 analogs. Eur J Med Chem. 91 (2015): 91-99 Link
2014
(203) DeToma AS., Krishnamoorhty J., Nam YW., Lee HJ., Brender JR., Kochi A., Lee DK., Onnis V., Congiu C., Manfredini S., Vertuani S., Balboni G., Ramamoorthy A., Lim MH., Synthetic Flavonoids, Amonoisoflavones: interaction and reactivity with metal-free and metal-associated amyloid-β species. Chem Sci. 5 (2014): 4851-4862 Link
(202) Mroue KH., Zhang R., Zhu P., McNerny E., Kohn DH., Morris MD., Ramamoorhty A., Acceleration of natural-abundance solid-state MAS NMR measurements on bone by paramagnetic relaxation from gadolinium-DTPA. J Magn Reson. 244 (2014): 90-97 Link
(201) Yesuvadian R., Krishnamoorthy J., Ramamoorthy A., Bhunia A., Potent γ-seretase inhibitors/modulators interact with amyloid-β fibrils but do not inhibit fibrillation: a high-resolution NMR study. Biochem Biophy Res Commun. 477(4):590-595 Link
(200) Patel H, Pithadia A., Brender J., Fierke C., Ramamoorthy A. In search of aggregation pathways of IAPP and other amyloidogenic proteins: finding answers through NMR spectroscopy. J. Phys. Chem. Lett. 5(11):1864-1870. Link
(199) Zhang RC., Ramamoorthy A. Performance of RINEPT is amplified by dipolar couplings under ultrafast MAS conditions. J. Magn Reson. 243(2014):85-92 Link
(198) Nishiyama Y., Malon M., Ishii Y., Ramamoorthy A. 3D 15N/15N/1H Chemical shift correlation experiments utilizing an RFDR-based 1H/1H mixing period at 100 kHz MAS. J. Magn Reson. 244(2014):1-5 Link
(197) Huang R., Yamamoto K., Zhang M., Popovych N., Hung I., Im SC., Gan ZH., Waskell L., Ramamoorthy A., Probing the transmembrane structure and dynamics of microsomal cytochrome P450 reductase by solid-state NMR, Biophys. J.106(2014), 2126-2133.
(196) Nishiyama Y, Zhang R, Ramamoorthy A. Finite-pulse radio frequency driven recoupling with phase cycling for 2D 1H/1H correlation at ultrafast MAS frequencies. J. Magn Reson. 243(2014):25-32 Link
(195) Pandey M, Vivekanandan S, Yamamoto K, Lm S C, Waskell L, Ramamoorthy A. Proton-detected 2D radio frequency driven recoupling solid-state NMR studies on micelle-associated cytochrome-b5. J. Magn. Reson. 242(2014):169-179 Link
(194) Kotler SA, Walsh P, Breander JR, Ramamoorthy A. Differences between amyloid-beta aggregation in solution and on the membrane: Insights in to elucidation of the mechanistic details of Alzheimer's disease. Chem. Soc. Rev. (In press). Link
(193) Yamamoto K, Paige P, Ramamoorthy A. Bicelles exhibiting magnetically-alignment for a broader range of temperatures - A solid state NMR study. Langmuir. 30(6):1622-1629 Link
(192) Lee S, Zheng X, Krishnamoorthy J, Savelieff M, Park M, Brender JR, Kim H, Derrick S, Kochi A, Lee J, Kim C, Ramamoorthy A, Bowers T, Lim MH. Rational design of a structural framework with potential use to develop chemical reagents that target and modulate multiple facets of Alzheimer's disease. J. Am. Chem. Soc. 136(2014) 299-319. Link
(191) Higashi K, Yamamoto K, Pandey M, Mroue K, Moribe K, Yamamoto K, Ramamoorthy A. Insights into atomic-level interaction between mefenamic acid and Eudragit EPO in a supersaturated solution by high-resolution magic-angle spinning NMR spectroscopy. Mol Pharm. 11(2014) 351-357. Link
2013
(190) Zhao J, Hu R, Sciacca MF, Brender JR, Chen H, Ramamoorthy A, Zheng J. Non-selective ion channel activity of polymorphic human islet amyloid polypeptide (amylin) double channels. Phys. Chem. Chem. Phys. (In press). Link
(189) Tsukamoto M, Kuroda K, Ramamoorthy A, Yasuhara K. Modulation of raft domains in a lipid bilayer by boundary active curcumin. Chem. Comm. (In press). Link
(188) Savelieff M, Liu Y, Senthamarai R, Korshavn K, Lee H, Ramamoorthy A, Lim MH, A small molecule that displays marked reactivity with copper-- versus zinc-amyloid-beta implicated in Alzheimer's disease. Chem. Comm. (In press). Link
(187) Yamamoto K, Caporino M, Im SC, Waskell L, Ramamoorthy A. Shortening spin-lattice relaxation using a copper-chelated lipid at low-temperatures-- A magic angle spinning solid-state NMR study on a membrane-bound protein. J. Magn. Reson. 237(2013) 175-181. Link
(186) Pandey M, Vivekanandan S, Ahuja S, Huang R, Im, SC, Waskell L and Ramamoorthy A. Cytochrome-P450-Cytochrome-b5 interaction in a membrane environment changes 15N chemical shift anisotropy tensors. J. Phys. Chem. B, 117(2013) 13851-13860. Link
(185) Vivekanandan S, Ahuja S, Lm SC, Waskell L and Ramamoorthy A. 1H, 13C and 15N resonance assignments for the full-length mammalian cytochrome b5 in a membrane environment. Biomol. NMR Assigm. 7(2013). Link
(184) Porcelli F, Ramamoorthy A, Barany G and Veglia G. On the role of NMR spectroscopy for characterization of Antimicrobial peptides. Membrane Proteins:Methods in Molecular Biology. 1063(2013) 159-180. Link
(183) Yamamoto K, Gildenberg M, Ahuja S, Im SC, Pearcy P, Waskell L, Ramamoorthy A. Probing the transmembrane structure and topology of microsomal cytochrome p450 by solid-state NMR on temperature resistant bicelles. Scientific Reports (Nature) 3:2556. Link
(182) Ramamoorthy A. Insights into protein misfolding and amyloidogenesis. Phys. Chem. Chem. Phys. 15(2013) 8867-8867. Link
(181) Ramamoorthy A and Lim MH. Structural characterization and inhibition of toxic amyloid-beta oligomeric intermediates. Biophys J. 105(2013) 287-288. Link
(180) Chatta AK, Mroue KH, Pfund LY, Ramamoorthy A, Longhi MR and Garnero C. Insights into novel supramolecular complexes of two solid forms of norfloxacin and beta-cylcodextrin. J. Pharm. Sci. (2013) Link
(179) McElderry JP, Zhu P, Mroue KH, Xu J, Pavan B, Fang M, Zhao G, McNerny E, Kohn DH, Franceschi RT, Banaszak-Holl MM, Tecklenberg MMJ, Ramamoorthy A and Morris MD. Crystallinity and compositional changes in carbonated apatite. Evidence from 31P solid state NMR, Raman and AFM analysis. J Solid State Chem. 206 (2013) 192-198. Link
(178) Yamamoto K, Durr UHN, Xu J, Lm SC, Waskell L and Ramamoorthy A. Dynamic interaction between membrane bound full length cytochrome p450 and b5 observed by solid-state NMR spectroscopy. Scientific Reports (Nature) 3:2538. Link
(177) Tripathi P, Somashekar BS, Ponnusamy M, Gursky A, Dailey S, Kunju P, Lee CT, Chinnaiyan AM, Rajendiran TM and Ramamoorthy A. HR-MAS NMR tissue metabolomic signatures cross-validated by mass spectrometry distinguish bladder cancer from benign disease. J Proteome Res. 12(2013) 3519-3528. Link
(176) Ahuja S, Jahr N, Im SC, Vivekanandan S, Popovych N, Le Clair S, Huang R, Soong R, Xu J, Yamamoto K, Nanga RPR, Bridges A, Waskell L and Ramamoorthy A. A model of the membrane-bound cytochrome b5-cytochrome P450 complex from NMR and mutagenesis data. J. Biol. Chem. 288(2013) 22080-22095. Link
(175) Ramamoorthy A and Xu J. 2D 1H/1H RFDR and NOESY NMR Experiments on a Membrane-Bound Antimicrobial Peptide Under Magic Angle Spinning. J. Phys. Chem. B. 117(2013) 6693-7000. Link
(174) Ding B, Soblosky L, Nguyen K, Geng J, Yu X, Ramamoorthy A, Chen Z. Physiologically-relevant modes of membrane interactions by the human antimicrobial peptide, LL-37, revealed by SFG experiments. Sci. Rep. 3(2013) 1-8. Link
(173) Lee DK, Brender JR, Sciacca MF, Krishnamoorthy J, Yu C, Ramamoorthy A. Lipid composition dependent membrane fragmentation and pore-forming mechanisms of membrane disruption by pexiganan (MSI-78). Biochemistry. 52(2013) 3254-3263. Link
(172) Suzuki Y, Brender JR, Soper MT, Krishnamoorthy J, Zhou Y, Ruotolo BT, Kotov NA, Ramamoorthy A, Marsh EN. Resolution of oligomeric species during the aggregation of Abeta1-40 using 19F NMR, Biochemistry. 52(2013) 1903-1912. Link
(171) Brender JR, Heyl DL, Samisetti S, Kotler SA, Osborne JM, Pesaru RR, Ramamoorthy A. Membrane disordering is not sufficient for membrane permeabilization by islet amyloidogenic polypeptide: studies of IAPP(20-29) fragments. Phys. Chem. Chem. Phys. 15(2013) 8908-8915. Link
(170) Brender JR, Krishnamoorthy J, Messina GML, Deb A, Vivekanandan S, LaRosa C, Penner-Hahn JE, Ramamoorthy A. Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide. Chem. Comm. 49(2013), 3339-3341. Link
(169) Hyung SJ, DeToma AS, Brender JR, Lee S, Vivekanandan S, Kochi A, Choi J, Ramamoorthy A, Ruotolo BT, Lim MH. Insights into antiamyloidogenic properties of the green tea extract(-)-epigallocatechin-3-gallate toward metal-associated amyloid-beta species. Proc. Natl. Acad. Sci. U S A. (In press). Link
(168) Dürr UHN, Soong R, Ramamoorthy A.When the detergent meets bilayer: Birth and coming of age of lipid bicelles. Prog. NMR Spec. 69(2013) 1-22. Link
(167) Sciacca MF, Milardi D, Messina GM, Marletta G, Brender JR, Ramamoorthy A, La Rosa C. Cations as switches of amyloid-mediated membrane disruption mechanisms: Calcium and IAPP. Biophys. J. 104(2013) 173-184. Link
(166) Hartman K, Brender JR, Monde K, Ono A, Evans ML, Popovych N, Chapman MR, Ramamoorthy A. Bacterial curli protein promotes the conversion of PAP(248-286) into the amyloid SEVI: cross-seeding of dissimiliar amyloid sequences. Peer J. (2013) DOI:10.7717/peerj.5. Link
(165) Pandey M, Ramamoorthy A. Quantum chemical calculation of amide-15N chemical shift anisotropy tensors for a membrane-bound cytochrome b5. J. Phys. Chem. B. 117(2013) 859-867. Link
(164) Mackinnon N, Somashekar BS, Tripathi P, Ge W, Rajendiran TM, Chinnaiyan AM, Ramamoorthy A. MetaboID: A graphical user interface package for assignment of 1H NMR spectra of bodyfluids and tissues. J. Magn. Reson. 226(2013) 93-99. Link
2012
(163) Krishnamoorthy J, Brender JR, Vivekanandan S, Jahr N, Ramamoorthy A. Side chain dynamics reveals transient association of Ab(1-40) monomers with amyloid fibers. J. Phys. Chem. B.116(2012) 13618-13623. Link
(162) Somashekar BS, Amin AG, Tripathi P, Mackinnon N, Rithner CD, Shanley CA, Basaraba R, Henao-Tamayo M, Kato-Maeda M, Ramamoorthy A, Orme IM, Ordway DJ, Chatterijee D. J. Proteome. Res. 11(2012) 4873-4884. Link
(161) Zhu J, Andres CM, Xu J, Ramamoorthy A, Tsotsis T, Kotov NA. Pseudonegative thermal expansion and state of water in graphene oxide layered assemblies. ACS Nano 6(2012) 8357-8365. Link
(160) Sciacca MF, Brender JR, Lee DK, Ramamoorthy A. Phosphatidylethanolamine enhances amyloid fiber-dependent membrane fragmentation. Biochemistry 51(2012) 7676-7684. Link
(159) Mroue KH, MacKinnon N, Xu J, Zhu P, McNerny E, Kohn DH, Morris MD, Ramamoorthy A. High-resolution structural insights into bone: a solid-state NMR relaxation study utilizing paramagnetic doping. J. Phys. Chem. B 116(2012) 11656-11661.Link
(158) Suzuki Y, Brender JR, Hartman K, Ramamoorthy A, Marsh EN. Alternative pathways of human islet amyloid polypeptide aggregation distinguished by 19F NMR-detected kinetics of monomer consumption. Biochemistry. 51(2012) 8154-8162. Link
(157) Dürr UHN, Gildenberg M, Ramamoorthy A. The magic of bicelles lights up membrane protein structure. Chem. Rev. 112 (2012) 6054-6074. Link
(156) McHenry AJ, Sciacca MF, Brender JR, Ramamoorthy A. Does cholesterol suppress the antimicrobial peptide induced disruption of lipid raft containing membranes? Biochim. Biophys. Acta, Biomembr. 1818 (2012) 3019-3024. Link
(155) Jones MR, Service EL, Thompson JR, Wang MCP, Kimsey IJ, DeToma AS, Ramamoorthy A, Lim MH, Storr T. Dual-function triazole-pyridine derivatives as inhibitors of metal-induced amyloid-beta aggregation. Metallomics 4 (2012) 910-920. Link
(154) Tripathi P, Kamarajan P, Somashekar BS, MacKinnon N, Chinnaiyan AM, Kapila YL, Rajendiran TM, Ramamoorthy A. Delineating Metabolic Signatures of Head and Neck Squamous Cell Carcinoma: Phospholipase A2, a Potential Therapeutc Target. Int. J. Biochem. Cell Biol. 44 (2012) 1852-1861. Link
(153) Sciacca MFM, Kotler SA, Brender JR, Chen J, Lee DK, Ramamoorthy A. Two step mechanism of membrane disruption by Aβ through membrane fragmentation and pore formation. Biophys. J. 103 (2012) 702-710. Link
(152) Brender JR, McHenry AJ, Ramamoorthy A. Does cholesterol play a role in the bacterial selectivity of antimicrobial peptides? Front. Immunol. 3 (2012) 1-4. Link
(151) Pandey M, Vivekanandan S, Ahuja S, Kumar P, Waskell L, Im S-C, Ramamoorthy A. Determination of 15N Chemical Shift Anisotropy from a Membrane Bound Protein by NMR Spectroscopy. J. Phys. Chem. B 116 (2012) 7181-7189. Link
(150) MacKinnon N, Ge W, Khan A, Somashekar B, Tripathi P, Siddiqui J, Wei J, Chinnaiyan A, Rajendira T, Ramamoorthy A. Variable Reference Alignment: an improved peak alignment protocol for NMR spectral data with large intersample variation. Anal. Chem. 84 (2012) 5372-5379. Link
(149) Khitrin A, Xu J, Ramamoorthy A. Coherent averaging in the frequency domain. J. Chem. Phys. 136 (2012) 214504. Link
(148) MacKinnon N, Khan AP, Chinnaiyan AM, Rajendiran TM, and Ramamoorthy A. Androgen receptor activation results in metabolite signatures of an aggressive prostate cancer phenotype: an NMR-based metabonomics study. Metabolomics 8(2012) 1026-1036. Link
(147) Popovych N, Brender JR, Soong R, Vivekanandan S, Hartman K, Basrur V, MacDonald PM, Ramamoorthy A. Site specific interaction of the polyphenol EGCG with the SEVI amyloid peptide PAP(248-286). J. Phys. Chem. B 116 (2012) 3650-3658. Link
(146) Brender J, Salamekh S, Ramamoorthy A. Membrane-disruption and early events in the aggregation of the diabetes related peptide IAPP from a molecular perspective. Acc. Chem. Res. 116 (2012) 3650–3658. Link
(145) Huang R, Vivekanandan S, Brender JR, Abe Y, Naito A, Ramamoorthy A. NMR Characterization of monomeric and oligomeric conformations of human calcitonin and its interaction with EGCG. J. Mol. Biol. 416 (2012) 108-120. Link
(144) Detoma AS, Salamekh S, Ramamoorthy A, Lim MH. Misfolded proteins in Alzheimer's disease and type II diabetes. Chem. Soc. Rev. 41 (2012) 608-621. Link
2011
(143) Moon JY, Kang Do, Cho YK, Kong KH, Lee DK, Ramamoorthy A. Characterization of factors favoring the recombinant expression and purification of LL-37 from Escherichia coli. J. Korean Soc. Appl. Biol. Chem. 54 (2011) 871-880. Link
(142) Tomonaga Y, Hidaka T, Kawamura I, Nishio T, Ohsawa K, Okitsu T, Wada A, Sudo Y, Kamo N, Ramamoorthy A, Naito A. An Active Photoreceptor Intermediate Revealed by In Situ Photoirradiated Solid-State NMR Spectroscopy. Biophys. J. 101 (2011) L50-L52. Link
(141) Braymer J, Choi J-S, DeToma A, Wang C, Nam K, Kampf J, Ramamoorthy A, Lim MH. Development of Bifunctional Stillbene Derivatives for Targeting and Modulating Metal-Amyloid-beta Species. Inorg. Chem. 50 (2011) 10724-10734. Link
(140) Yamamoto K, Vivekanandan S, Ramamoorthy A. Fast NMR Data Acquisition From Bicelles Containing a Membrane-Associated Peptide at Natural-Abundance. J. Phys. Chem. B. 115 (2011) 12448-12455. Link
(139) Somashekar B, Kamarajan P, Danciu T, Kapila Y, Chinnaiyan A, Rajendiran T, Ramamoorthy A. Magic Angle Spinning NMR Based Metabolic Profiling of Head and Neck Squamous Cell Carcinoma Tissues. J. Proteome R. 10 (2011) 5232-5241. Link
(138) Khitrin A, Xu J, Ramamoorthy A. Cross-Correlations Between Low-gamma Nuclei in Solids Via a Common Dipolar Bath. J. Magn. Reson. 212 (2011) 95-101. Link
(137) Nanga RPR, Brender JR, Vivekanandan S, Ramamoorthy A. Structure and Membrane Orientation of IAPP in its Natively Amidated Form at Physiological pH in a Membrane Environment. Biochim. Biophys. Acta, Biomembr. 10 (2011) 2337-2342. Link
(136) Xu JD, Zhu PZ, Morris MD, Ramamoorthy A. Solid-State NMR Spectroscopy Provides Atomic-Level Insights Into the Dehydration of Cartilage. J. Phys. Chem. B. 115 (2011) 9948-9954. Link
(135) Vivekanandan S, Brender JR, Lee SY, Ramamoorthy A. A Partially Folded Structure of Amyloid-Beta(1-40) in an Aqueous Environment. Biochem. Biophys. Res. Commun. 411 (2011) 312-316. Link
(134) Salamekh S, Brender JR, Hyung S-J, Nanga RP, Vivekanandan S, Ruotolo BT, Ramamoorthy A. A Two Site Mechanism for the Inhibition of IAPP Amyloidogenesis by Zinc. J. Mol. Biol. 410 (2011) 294-306. Link
(133) Yang P, Ramamoorthy A, Chen Z. Membrane Orientation of MSI-78 Measured by Sum Frequency Generation Vibrational Spectroscopy. Langmuir 27 (2011) 7760-7767. Link
(132) Yoo S II, Yang M, Brender JR, Vivekanandan S, Sun K, Joo NE, Jeong S-H, Ramamoorthy A, and Kotov NA. Inhibition of Amyloid Peptide Fibrillation by Inorganic Nanoparticles: Functional Similarities with Proteins. Angew. Chem. Int. Ed. 50 (2011) 1-7. Link
(131) Xu J, Smith PES, Soong R, Ramamoorthy A. A Proton Diffusion Based Solid-State NMR Approach for Structural Studies on Aligned Samples. J. Phys. Chem. B. 115 (2011) 4863-4871. Link
(130) Brender JR, Lee EL, Hartman K, Wong PT, Ramamoorthy A, Steel DG, Gafni A. Biphasic effects of insulin on islet amyloid polypeptide membrane disruption. Biophys. J. 100 (2011) 685-692. Link
(129) Brender JR, Nanga RP, Popovych N, Soong R, Macdonald PM, Ramamoorthy A. The amyloidogenic SEVI precursor, PAP248-286, is highly unfolded in solution despite an underlying helical tendency. Biochim. Biophys. Acta, Biomembr. 1808 (2011) 1161-1169. Link
(128) Zimmerman LB, Worley BV, Palermo EF, Brender JR, Lee KD, Kuroda K, Ramamoorthy A, Meyerhoff ME. Absorbance-based assay for membrane disruption by antimicrobial peptides and synthetic copolymers using pyrroloquinoline quinone-loaded liposomes. Anal. Biochem. 411 (2011) 194-199. Link
(127) Palermo E, Lee D-K, Ramamoorthy A, Kuroda K. The Role of Cationic Group Structure in Membrane Binding and Disruption by Amphiphilic Copolymers. J. Phys. Chem. B. 115 (2011) 366-375. Link
(126) Lutker KM, Quiñones R, Xu J, Ramamoorthy A, Matzger AJ. Polymorphs and hydrates of acyclovir. J. Pharm. Sci. 100 (2011) 949-963. Link
2010
(125) Domadia PN, Bhunia A, Ramamoorthy A, Bhattacharjya S. Structure, Interactions, and Antibacterial Activities of MSI-594 Derived Mutant Peptide MSI-594F5A in Lipopolysaccharide Micelles: Role of the Helical Hairpin Conformation in Outer-Membrane Permeabilization. J. Am. Chem. Soc. 132 (2010) 18417-18428. Link
(124) Choi J-S, Braymer JJ, Nanga RPR, Ramamoorthy A, Lim MH. Design of small molecules that target metal-Abeta species and regulate metal-induced Abeta aggregation and neurotoxicity. Proc. Natl. Acad. Sci. U S A. 107 (2010) 21990-21995. Link
(123) Thennarasu S, Huang R, Lee D-K, Yang P, Maloy L, Chen Z, Ramamoorthy A. Limiting an Antimicrobial Peptide to the Lipid-Water Interface Enhances Its Bacterial Membrane Selectivity: A Case Study of MSI-367. Biochemistry. 49 (2010) 10595-10605. Link
(122) Nguyen KT, Soong R, Im S-C, Waskell L, Ramamoorthy A, Chen Z. Probing the Spontaneous Membrane Insertion of a Tail-Anchored Membrane Protein by Sum Frequency Generation. J. Am. Chem. Soc. 132 (2010) 15112-15115. Link
(121) Xu J, Zhu P, Gan Z, Sahar N, Tecklenburg M, Morris MD, Kohn DH, Ramamoorthy A. Natural-Abundance 43Ca Solid-State NMR Spectroscopy of Bone. J. Am. Chem. Soc. 132 (2010) 11504-11509. Link
(120) Xu J, Soong R, Im SC, Waskell L, Ramamoorthy A. INEPT-Based Separated-Local-Field NMR Spectroscopy: A Unique Approach to Elucidate Side-Chain Dynamics of Membrane-Associated Proteins. J. Am. Chem. Soc. 132 (2010) 9944-9947. Link
(119) Brender JR, Hartman K, Nanga RPR, Popovych N, de la Salud Bea R, Vivekanandan S, Marsh ENG, Ramamoorthy A. Role of Zinc in Human Amyloid Polypeptide Aggregation. J. Am. Chem. Soc. 132 (2010) 8973-8983. Link
(118) Saito H, Ando I, Ramamoorthy A. Chemical shift tensor - The heart of NMR: Insights into biological aspects of proteins. Prog. NMR Spec. 57 (2010) 181-228. Link
(117) Epand RF, Maloy L, Ramamoorthy A, Epand RM. Amphipathic Helical Cationic Antimicrobial Peptides Promote Rapid Formation of Crystalline States in the Presence of Phosphatidylglycerol: Lipid Clustering in Anionic Membranes. Biophys. J. 98 (2010) 2564-2573. Link
(116) Smith PES, Brender JR, Dürr UHN, Xu J, Mullen DG, Banaszack Holl MM, Ramamoorthy A. Solid-State NMR Reveals the Hydrophobic-Core Location of Poly(amidoamine) Dendrimers in Biomembranes. J. Am. Chem. Soc. 132 (2010) 8087-8097. Link
(115) Yamamoto K, Xu J, Kawulka KE, Vederas JC, Ramamoorthy A. Use of a copper-chelated lipid speeds up NMR measurements from membrane proteins. J. Am. Chem. Soc. 132 (2010) 6929-6931. Link
(114) Soong R, Smith PE, Xu J, Yamamoto K, Im SC, Waskell L, Ramamoorthy A. Proton-evolved local-field solid-state NMR studies of cytochrome b5 embedded in bicelles, revealing both structural and dynamical information. J. Am. Chem. Soc. 132 (2010) 5779-5788. Link
(113) Epand RF, Maloy WL, Ramamoorthy A, Epand RM. Probing the "Charge Cluster Mechanism" in Amphipathic Helical Cationic Antimicrobial Peptides. Biochemistry 49 (2010) 4076-4084. Link
(112) Bhunia A, Domadia PN, Hallock KJ, Ramamoorthy A, Bhattacharjya S. NMR Structure of Pardaxin, a Pore-Forming Antimicrobial Peptide, in Lipopolysaccharide Micelles: Mechanism of Outer membrane Permeabilization. J. Biol. Chem. 285 (2010) 3883-3895. Link
(111) Veglia G and Ramamoorthy A. Preface: Special issue on "Membrane Protein Dynamics: Correlating Structure to Function" Biochim. Biophys. Acta, Biomembr. 1798 (2010) 65-67. Link
(110) Ramamoorthy A, Lee D-K, Narasimhaswamy T, Nanga RPR. Cholesterol reduces pardaxin's dynamics-a barrel-stave mechanism of membrane disruption investigated by solid-state NMR. Biochim. Biophys. Acta, Biomembr. 1798 (2010) 223-227. Link
(109) Io T, Fukami T, Yamamoto K, Suzuki T, Xu JD, Tomono K, Ramamoorthy A. Homogeneous Nanoparticles To Enhance the Efficiency of a Hydrophobic Drug, Antihyperlipidemic Probucol, Characterized by Solid-State NMR. Mol. Pharmaceutics 7 (2010) 299-305. Link
(108) Thennarasu S, Tan AM, Penumatchu R, Shelburne CE, Heyl DL, Ramamoorthy A. Antimicrobial and Membrane Disrupting Activities of a Peptide Derived from the Human Cathelicidin Antimicrobial Peptide LL37. Biophys. J. 98 (2010) 248-257. Link
2009
(107) Nanga RPR, Brender JR, Vivekanandan S, Popovych N, Ramamoorthy A. NMR Structure in a Membrane Environment Reveals Putative Amyloidogenic Regions of the SEVI Precursor Peptide PAP(248-286). J. Am. Chem. Soc. 131 (2009) 17972-17979. Link
(106) Zhu PZ, Xu JD, Sahar N, Morris MD, Kohn DH, Ramamoorthy A. Time-Resolved Dehydration-induced Structural Changes in an Intact Bovine Cortical Bone Revealed by Solid-State NMR Spectroscopy. J. Am. Chem. Soc. 131 (2009) 17064-17065. Link
(105) Hindo SS, Mancino AM, Braymer JJ, Liu YH, Vivekanandan S, Ramamoorthy A, Lim MH. Small Molecule Modulators of Copper-Induced A beta Aggregation. J. Am. Chem. Soc. 131 (2009) 16663-16665. Link
(104) Brender JR, Hartman K, Gottler LM, Cavitt ME, Youngstrom DW, Ramamoorthy A. Helical Conformation of the SEVI Precursor Peptide PAP(248-286), a Dramatic Enhancer of HIV Infectivity, Promotes Lipid Aggregation and Fusion. Biophys. J. 97 (2009) 2474-2483. Link
(103) Bhattacharjya S, Ramamoorthy A. Multifunctional host defense peptides: functional and mechanistic insights from NMR structures of potent antimicrobial peptides. FEBS J. 276 (2009) 6465-6473. Link
(102) Marsh ENG, Buer BC, Ramamoorthy A. Fluorine-a new element in the design of membrane-active peptides. Mol. BioSyst. 5 (2009) 1143-1147. Link
(101) Gottler L and Ramamoorthy A. Membrane Orientation, Mechanism, and Function of Pexiganan - A Highly Potent Antimicrobial Peptide Designed From Magainin. Biochim. Biophys. Acta, Biomembr. 1788 (2009) 1680-1686. Link
(100) Ramamoorthy A. Beyond NMR spectra of antimicrobial peptides: Dynamical images at atomic resolution and functional insights. Solid State Nucl. Magn. Reson. 35 (2009) 201-207. Link
(99) Nanga RPR, Brender JR, Xu J, Hartman K, Vivekanandan S, Ramamoorthy A., Three-dimensional structure and orientation of rat islet amyloid polypeptide protein in a membrane environment by solution NMR spectroscopy. J. Am. Chem. Soc. 131 (2009) 8252-8261. Link
(98) Yamamoto K, Soong R, Ramamoorthy A. Comprehensive Analysis of Lipid Dynamics Variation with Lipid Composition and Hydration of Bicelles Using Nuclear Magnetic Resonance (NMR) Spectroscopy. Langmuir 25 (2009) 7010-7018. Link
(97) Soong R, Brender JR, MacDonald PM, Ramamoorthy A. Association of Highly Compact Type II Diabetes Related Islet Amyloid Polypeptide Intermediate Species at Physiological Temperature Revealed by Diffusion NMR Spectroscopy. J. Am. Chem. Soc. 131 (2009) 7079-7085. Link
(96) Fukami T, Ishii T, Io T, Suzuki N, Suzuki T, Yamamoto K, Xu JD, Ramamoorthy A, Tomono K. Nanoparticle Processing in the Solid State Dramatically Increases the Cell Membrane Permeation of a Cholesterol-Lowering Drug, Probucol. Mol. Pharmaceutics 6 (2009) 1029-1035. Link
(95) Barry J, Fritz M, Brender JR, Smith PES, Lee D-K, Ramamoorthy A, Determining the Effects of Lipophillic Drugs on Membrane Structure by Solid-State NMR Spectroscopy: The Case of the Antioxidant Curcumin. J. Am. Chem. Soc. 131 (2009) 4490-4498. Link
(94) Smith PES, Brender JR, Ramamoorthy A. The Induction of Negative Curvature as a Mechanism of Cell Toxicity by Amyloidogenic Peptides: The Case of Islet Amyloid Polypeptide. J. Am. Chem. Soc. 131 (2009) 4470-4478. Link
(93) Kandasamy SK, Lee D-K, Nanga RPR, Xu J, Santos JS, Larson R, Ramamoorthy A. Solid-state NMR and Molecular Dynamics Simulations Reveal the Oligomeric Ion-channels of TM2-GABAA Stabilized by Intermolecular Hydrogen Bonding. Biochim. Biophys. Acta, Biomembr. 1788 (2009) 686-695. Link
(92) Fukuchi A, Ramamoorthy A, Takegoshi K. Efficient Cross-Polarization Using a Composite 0 degree Pulse for NMR Studies on Static Solids. J. Magn. Reson. 196 (2009) 105-109. Link
(91) Bhunia A, Ramamoorthy A, Bhattacharjya S. Helical Hairpin Structure of a Potent Antimicrobial Peptide MSI-594 in Lipopolysaccharide Micelles by NMR Spectroscopy. Chem. Eur. J. 15 (2009) 2036-2040. Link
2008
(90) Nanga RPR, Brender JR, Xu J, Veglia G, Ramamoorthy A. Structures of Rat and Human Islet Amyloid Polypeptides in Membranes by NMR Spectroscopy and their Implications in Cell Toxicity. Biochemistry 47 (2008) 12689-12697. Link
(89) Lee D-K, Kwon B-S, Ramamoorthy A. Freezing Point Depression in Water in Phospholipid Membranes - A Solid-State NMR Study. Langmuir 24 (2008) 13598-13604. Link
(88) Brender JR, Hartman K, Reid K, Kennedy R, Ramamoorthy A. A Single Mutation in the Non-Amyloidogenic Region of IAPP Greatly Reduces Toxicity. Biochemistry 47 (2008) 12680-12688. Link
(87) Dvinskikh SV, Yamamoto K, Scanu D, Deschenaux R, Ramamoorthy A. High-Resolution Characterization of Liquid-Crystalline [60]Fullerenes Using Solid-State Nuclear Magnetic Resonance Spectroscopy. J. Phys. Chem. B. 112 (2008) 12347-12353. Link
(86) Xu J, Dürr UHN, Im SC, Gan Z, Waskell L, Ramamoorthy A. Bicelle-Enabled Structural Studies on Membrane Protein Cytochrome b5 by Solid-State MAS NMR Spectroscopy. Angew. Chem. Int. Ed. 47 (2008) 7864-7867. Link
(85) Gottler LM, de la Salud Bea R, Shelburne CE, Ramamoorthy A, Marsh EN. Using Flourous Amino Acids to Probe the Effects of Changing Hydrophobicity on the Physical and Biological Properties of the Beta-Hairpin Antimicrobial Peptide Protegrin-1. Biochemistry. 47 (2008) 9243-9250. Link
(84) Ramamoorthy A, Lee D-K, Santos JS, Henzler-Wildman KA. Nitrogen-14 Solid-State NMR Spectroscopy of Aligned Phospholipid Bilayers to Probe Peptide-Lipid Interaction and Oligomerization of Membrane Associated Peptides. J. Am. Chem. Soc. 130 (2008) 11023-11029. Link
(83) Brender JR, Lee EL, Cavitt MA, Gafni A, Steel DG, Ramamoorthy A. Amyloid Fiber Formation and Membrane Disruption are Separate Processes Localized in Two Distinct Regions of IAPP, the Type-2-Diabetes-Related Peptide. J. Am. Chem. Soc. 130 (2008) 6424-6429. Link
(82) Porcelli F, Verardi R, Shi L, Henzler-Wildman KA, Ramamoorthy A, Veglia G. NMR Structure of the Cathelicidin-Derived Human Antimicrobial Peptide LL-37 in Dodecylphosphocholine Micelles. Biochemistry 47 (2008) 5565-5572. Link
(81) Gottler LM, Lee HY, Shelburne CE, Ramamoorthy A, Marsh ENG. Using Fluorous Amino Acids to Modulate the Biological Activity of an Antimicrobial Peptide. ChemBioChem 9 (2008) 370-373. Link
(80) Hoskin DW, Ramamoorthy A. Studies on anticancer activities of antimicrobial peptides. Biochim. Biophys. Acta, Biomembr. 1778 (2008) 357-375. Link
(79) Xu J, Struppe J, Ramamoorthy A. Two-dimensional homonuclear chemical shift correlation established by the cross-relaxation driven spin diffusion in solids. J. Chem. Phys. 128 (2008) 052308. Link
2007
(78) Dürr UHN, Waskell L, Ramamoorthy A. The cytochromes P450 and b5 and their reductases-Promising targets for structural studies by advanced solid-state NMR spectroscopy. Biochim. Biophys. Acta, Biomembr. 1768 (2007) 3235-3259. Link
(77) Podsiadlo P, Kaushik AK, Arruda EM, Waas AM, Sup B, Shim, Xu J, Nandivada H, Pumplin BG, Lahann J, Ramamoorthy A, Kotov NA. Ultrastrong and Stiff Layered Polymer Nanocomposites. Science 318 (2007) 80-83. Link
(76) Brender JR, Dürr UHN, Heyl D, Budarapu MB, Ramamoorthy A. Membrane Fragmentation by an Amyloidogenic Fragment of Human Islet Amyloid Polypeptide Detected by Solid-State NMR Spectroscopy of Membrane Nanotubes. Biochim. Biophys. Acta, Biomembr. 1768 (2007) 2026-2029. Link
(75) Dürr UHN, Yamamoto K, Im SC, Waskell L, Ramamoorthy A. Solid-State NMR Reveals Structural and Dynamical Properties of a Membrane-Anchored Electron-Carrier Protein, Cytochrome b5. J. Am. Chem. Soc. 129 (2007) 6670-6671. Link
(74) Textbook: A. Ramamoorthy (Ed.), Thermotropic Liquid Crystals: Recent Advances, Springer, Dordrecht, The Netherlands 2007.
(73) Shelburne C, An F, Dhople V, Ramamoorthy A, Lopatin D, Lantz M. The spectrum of anti-microbial activity of the bacteriocin Subtilosin A. J. Antimicrob. Chemother. 59 (2007) 297-300. Link
(72) Dvinskikh SV, Yamamoto K, Dürr UHN, Ramamoorthy A. Sensitivity and resolution enhancement in solid-state NMR spectroscopy of bicelles. J. Magn. Reson. 184 (2007) 228-235. Link
(71) Dvinskikh SV, Dürr UHN, Yamamoto K, Ramamoorthy A. High-resolution 2D NMR spectroscopy of bicelles to measure the membrane interaction of ligands. J. Am. Chem. Soc. 129 (2007) 794-802. Link
(70) Ramamoorthy A, Kandasamy SK, Lee D-K, Kidambi S, Larson RG. Structure, Topology and tilt of cell-signaling peptides containing nuclear localization sequences in membrane bilayers determined by solid-state NMR and molecular dynamics simulation studies. Biochemistry 46 (2007) 965-975. Link
2006
(69) Special issue: A. Ramamoorthy (Ed.). Membrane biophysics of antimicrobial peptides. Biochim. Biophys. Acta 1758 (2006) 1177-1540. Link
(68) Dhople V, Krukemeyer A, Ramamoorthy A. The human beta-defensin-3, an antibacterial peptide with multiple biological functions. Biochim. Biophys. Acta, Biomembr. 1758 (2006) 1499-1512. Link
(67) Dürr UHN, Sudheendra US, Ramamoorthy A. LL-37, the only human member of the cathelicidin family of antimicrobial peptides. Biochim. Biophys. Acta, Biomembr. 1758 (2006) 1408-1425. Link
(66) Moon JY, Henzler-Wildman KA, Ramamoorthy A. Expression and purification of a recombinant LL-37 from Escherichia coli. Biochim. Biophys. Acta, Biomembr. 1758 (2006) 1351-1358. Link
(65) Dvinskikh SV, Yamamoto K, Ramamoorthy A. Heteronuclear isotropic mixing separated local field NMR spectroscopy. J. Chem. Phys. 125 (2006) 034507. Link
(64) Ramamoorthy A, Thennarasu S, Lee D-K, Tan A, Maloy L. Solid-State NMR investigation of the membrane-disrupting mechanism of antimicrobial peptides MSI-78 and MSI-594 derived from Magainin 2 and Melittin. Biophys. J. 91 (2006) 206-216. Link
(63) Ramamoorthy A, Thennarasu S, Tan A, Gottipati K, Sreekumar S, Heyl DL, An FYP, Shelburne CE. Deletion of all cycteines in Tachyplesin I abolishes hemolytic activity and retains antimicrobial activity and LPS selective binding. Biochemistry 45 (2006) 6529-6540. Link
(62) Dvinskikh SV, Dürr U, Yamamoto K, Ramamoorthy A. A high-resolution solid-state NMR approach for the structural studies of bicelles. J. Am. Chem. Soc. 128 (2006) 6326-7. Link
(61) Porcelli F, Buck-Koehntop B, Thennarasu S, Ramamoorthy A, Veglia G. Structures of the dimeric and monomeric variants of magainin antimicrobial peptides (MSI-78 and MSI-594) in micelles and bilayers by NMR spectroscopy. Biochemistry 45 (2006) 5793-5799. Link
(60) Yamamoto K, Dvinskikh SV, Ramamoorthy A. Measurement of heteronuclear dipolar couplings using a rotating frame solid-state NMR experiment. Chem. Phys. Lett. 419 (2006) 533-536. Link
(59) Dvinskikh SV, Yamamoto K, Ramamoorthy A. Separated local field NMR spectroscopy by windowless isotropic mixing. Chem. Phys. Lett. 419 (2006) 168-173. Link
(58) Textbook: A. Ramamoorthy (Ed.). NMR Spectroscopy of Biological Solids, Taylor & Francis, Ramamoorthy A, Thennarasu S, Tan A, Lee D-K, Clayberger C, Krensky AM, Cell selectivity correlates with membrane-specific interactions: A case study on the antimicrobial peptide G15 derived from granulysin, Biochim. Biophys. Acta, Biomembr. 1758 (2006) 154-163. Link
(57) Saalwachter K, Ramamoorthy A, Sensitivity enhancement by inverse detection in solids, NMR Spectroscopy of Biological Solids, Taylor and Francis Group, New York (2006) 151-175.
(56) Fujiwara T, Ramamoorthy A. How far can the sensitivity of NMR be increased? Ann. Rep. NMR Spectrosc. 58 (2006) 155-175.
(55) Epand RF, Ramamoorthy A. Epand RM, Membrane lipid composition and the interaction of pardaxin: The role of cholesterol. Prot. Pept. Lett. 13 (2006) 1-5. Link
2005
(54) Mecke A, Lee D-K, Ramamoorthy A, Orr BG, Holl MMB. Membrane thinning due to antimicrobial peptide binding: An atomic force microscopy study of MSI-78 in lipid bilayers. Biophys. J. 99 (2005) 4043-4050. Link
(53) Powers JPS, Tan A, Ramamoorthy A, Hancock REW. Solution structure and interaction of the antimicrobial polyphemusins with lipid membranes. Biochemistry 44 (2005) 15504-15513. Link
(52) Narasimhaswamy T, Monette M, Lee D-K, Ramamoorthy A. Solid-state NMR characterization and determination of the orientational order of a nematogen. J. Phys. Chem. B 109 (2005) 19696-19703. Link
(51) Thennarasu S, Lee D-K, Poon A, Kawulka KE, Vederas JC, Ramamoorthy A. Membrane permeabilization, orientation, and antimicrobial mechanism of subtilosin A. Chem. Phys. Lipids 137 (2005) 38-51. Link
(50) Mecke A, Lee D-K, Ramamoorthy A, Orr BG, Holl MMB. Synthetic and natural polycationic polymer nanoparticles interact selectively with fluid-phase domains of DMPC lipid bilayers. Langmuir 21 (2005) 8588-8590. Link
(49) Narasimhaswamy T, Lee D-K, Somanathan N, Ramamoorthy A. Solid-state NMR characterization of a novel thiophene-based three phenyl ring mesogen. Chem. Materials 17 (2005) 4567-4569. Link
(48) Yamamoto K, Ermakov VL, Lee D-K, Ramamoorthy A. PITANSEMA-MAS, a solid-state NMR method to measure heteronuclear dipolar couplings under MAS. Chem. Phys. Lett. 408 (2005) 118-122. Link
(47) Thennarasu S, Lee D-K, Tan A, Kari UP, Ramamoorthy A. Antimicrobial activity and membrane selective interactions of a synthetic lipopeptide MSI-843. Biochim. Biophys. Acta, Biomembr. 1711 (2005) 49-58. Link
(46) Yamamoto K, Lee D-K, Ramamoorthy A. Broadband-PISEMA solid-state NMR spectroscopy. Chem. Phys. Lett. 407 (2005) 289-293. Link
(45) Narasimhaswamy T, Lee D-K, Yamamoto K, Somanathan N, Ramamoorthy A. A 2D solid-state NMR experiment to resolve overlapping aromatic resonances of thiophene-based nematogens. J. Am. Chem. Soc. 127 (2005) 6958-6959. Link
(44) Narasimhaswamy T, Somanathan N, Lee D-K, Ramamoorthy A. Synthesis and C-13 CPMAS NMR characterization of novel thiophene-based nematogens. Chem. Materials 17 (2005) 2013-2018. Link
2004
(43) Lee D-K, Narasimhaswamy T, Ramamoorthy A, PITANSEMA, a low-power PISEMA solid-state NMR experiment, Chem. Phys. Lett. 399 (2004) 359-362. Link
(42) Pointer-Keenan CD, Lee D-K, Hallock K, Tan AM, Zand R, Ramamoorthy A. Investigation of the interaction of myelin basic protein with phospholipid bilayers using solid-state NMR spectroscopy. Chem. Phys. Lip. 132 (2004) 47-54. Link
(41) Mecke A, Uppuluri S, Sassanella TM, Lee D-K, Ramamoorthy A, Baker JR, Orr BG, Holl MMB. Direct observation of lipid bilayer disruption by poly(amidoamine) dendrimers. Chem. Phys. Lip. 132 (2004) 3-14. Link
(40) Porcelli F, Buck B, Lee D-K, Hallock KJ, Ramamoorthy A, Veglia G. Structure and orientation of pardaxin determined by NMR experiments in model membranes. J. Biol. Chem. 279 (2004) 45815-45823. Link
(39) Poon A, Birn J, Ramamoorthy A. How does an amide-N-15 chemical shift tensor vary in peptides? J. Phys. Chem. B 108 (2004) 16577-16585. Link
(38) Ramamoorthy A, Wei YF, Lee D-K. PISEMA solid-state NMR spectroscopy. Ann. Rep. NMR Spectrosc. 52 (2004) 1-52.
(37) Bim J, Poon A, Mao Y, Ramamoorthy A. Ab initio study of C-13 alpha chemical shift anisotropy tensors in peptides. J. Am. Chem. Soc. 126 (2004) 8529-8534. Link
(36) Henzler-Wildman KA, Martinez GV, Brown MF, Ramamoorthy A. Perturbation of the hydrophobic core of lipid bilayers by the human antimicrobial peptide LL-37. Biochemistry 43 (2004) 8459-8469. Link
(35) Wildman KAH, Ramamoorthy A, Wakamiya T, Yoshikawa T, Crisma M, Toniolo C, Formaggio F. A study of a C-alpha,C-beta-didehydroalanine homo-oligopeptide series in the solid-state by C-13 cross-polarization magic angle spinning NMR. J. Pept. Sci. 10 (2004) 336-341. Link
(34) Lee D-K, Wildman KH, Ramamoorthy A. Solid-state NMR spectroscopy of aligned lipid bilayers at low temperatures. J. Am. Chem. Soc. 126 (2004) 2318-2319. Link
(33) Santos JS, Lee D-K, Ramamoorthy A. Effects of antidepressants on the conformation of phospholipid headgroups studied by solid- state NMR. Magn. Reson. Chem. 42 (2004) 105-114. Link
2003
(32) Kidambi S, Schurko RW, Hung I, Ramamoorthy A. Nuclear magnetic resonance studies of metals in solid state non-metallic materials. Mater. Sci. Tech. 19 (2003) 1191-1196. Link
(31) Wildman KAH, Wilson EE, Lee D-K, Ramamoorthy A. Determination of the conformation and stability of simple homopolypeptides using solid-state NMR. Solid State Nucl. Magn. Reson. 24 (2003) 94-109. Link
(30) Wildman KAH, Lee D-K, Ramamoorthy A. Mechanism of lipid bilayer disruption by the human antimicrobial peptide, LL-37. Biochemistry 42 (2003) 6545-6558. Link
(29) Kidambi S, Lee D-K, Ramamoorthy A. Interaction of Cd and Zn with biologically important ligands characterized using solid-state NMR and ab initio calculations. Inorg. Chem. 42 (2003) 3142-3151. Link
(28) Hallock KJ, Lee D-K, Ramamoorthy A. MSI-78, an analogue of the magainin antimicrobial peptides, disrupts lipid bilayer structure via positive curvature strain. Biophys. J. 84 (2003) 3052-3060. Link
(27) Mascioni A, Porcelli F, Ilangovan U, Ramamoorthy A, Veglia G. Conformational preferences of the amylin nucleation site in SDS micelles: An NMR study. Biopolymers 69 (2003) 29-41. Link
(26) Kidambi S, Lee D-K, Ramamoorthy A. Characterization of metal centers in bioinorganic complexes using ab initio calculations of Cd-113 chemical shifts. Inorg. Chem. 42 (2003) 2200-2202. Link
2002
(25) Kidambi S, Ramamoorthy A. Quantum chemical calculations of cadmium chemical shifts in inorganic complexes. J. Phys. Chem. A. 106 (2002) 10363-10369. Link
(24) Wei Y, Lee D-K, McDermott AE, Ramamoorthy A. A 2D MAS solid-state NMR method to recover the amplified heteronuclear dipolar and chemical shift anisotropic interactions. J. Magn. Reson. 158 (2002) 23-35. Link
(23) Henzler Wildman KA, Lee D-K, Ramamoorthy A. Determination of effect of a-helix and b-sheet stability in the solid-state: A solid-state NMR investigation of poly(L-alanine). Biopolymers 64 (2002) 246-254. Link
(22) Hallock KJ, Lee D-K, Omnaas J, Mosberg HI, Ramamoorthy A. Membrane composition determines pardaxin's mechanism of lipid bilayer disruption. Biophys. J. 83 (2002) 1004-1013. Link
(21) Shekar SC, Lee D-K, Ramamoorthy A. Chemical shift anisotropy and offset effects in cross polarization solid-state NMR spectroscopy. J. Magn. Reson. 157 (2002) 223-234. Link
(20) Hallock KJ, Henzler Wildman KA, Lee D-K, Ramamoorthy A. An innovative procedure using a sublimable solids can be used to mechanically align lipid bilayers for solid-state NMR studies. Biophys. J. 82 (2002) 2499-2503. Link
(19) Shekar SC, Ramamoorthy A, Wittebort RJ. Determination of the chemical shielding orientation from two or one of the three conventional rotations of a single crystal. J. Magn. Reson. 155 (2002) 257-262. Link
(18) Taylor DM, Ramamoorthy A. Coherence transfer through homonuclear dipolar coupling in an unoriented two spin-1/2 solid-state system. J. Mol. Struct. 602-603 (2002) 115-124. Link
(17) Wei YF, Lee D-K, Hallock KJ, Ramamoorthy A. One-dimensional 1H-detected solid-state NMR experiment to determine amide-1H chemical shifts in peptides. Chem. Phys. Lett. 351 (2002) 42-46. Link
(16) Santos JS, Lee D-K, Hallock KJ, Ramamoorthy A. Cholesterol and antidepressant drug interactions with phospholipids - A solid-state NMR study, Recent Research Developments in Physical Chemistry, Transworld Research Network 6 (2002) 179-211.
2001
(15) Shekar SC, Lee D-K, Ramamoorthy A. An experimental strategy to dramatically reduce the RF power used in cross polarization solid-state NMR spectroscopy. J. Am. Chem. Soc. 123 (2001) 7467-7468. Link
(14) Wei YF, Ramamoorthy A. 2D 15N-15N isotropic chemical shift correlation established by 1H-1H dipolar coherence transfer in biological solids. Chem. Phys. Lett. 342 (2001) 312-316. Link
(13) Shekar SC, Ramamoorthy A. The unitary evolution operator for cross-polarization schemes in NMR. Chem. Phys. Lett. 342 (2001) 127-134. Link
(12) Wei Y, Lee D-K, Ramamoorthy A. Solid-state 13C chemical shift anisotropy tensors of polypeptides. J. Am. Chem. Soc. 123 (2001) 6118-6126. Link
(11) Wei Y, Lee D-K, Ramamoorthy A. A two-dimensional magic angle decoupling and magic angle turning solid-state NMR method - An application to study chemical shift tensors from peptides that are non-selectively labeled with 15N isotope. J. Phys. Chem. B 104 (2001) 4752-4762. Link
(10) Brender JR, Taylor DM, Ramamoorthy A. Orientation of amide-nitrogen-15 chemical shift tensors in peptides: A quantum chemical study. J. Am. Chem. Soc. 123 (2001) 914-922. Link
2000
(9) Hallock KJ, Lee D-K, Ramamoorthy A. The effects of librations on the 13C chemical shift and 2H electric field gradient tensors in beta-calcium formate. J. Chem. Phys. 113 (2000) 11187-11193. Link
(8) Wei YF, Lee D-K, Ramamoorthy A. One-dimensional dipolar-shift spectroscopy under magic angle spinning to determine the chemical-shift anisotropy tensors. Chem. Phys. Lett. 324 (2000) 20-24. Link
(7) Stout KL, Hallock KJ, Kampf JW, Ramamoorthy A. N-Acetyl-L-phenylalanine. Acta Cryst. C56 (2000) e100. Link
1999
(6) Taylor DM, Ramamoorthy A. Analysis of dipolar-coupling mediated coherence transfer in a homonuclear two spin 1/2 solid-state system. J. Magn. Reson. 141 (1999) 18-28. Link
(5) Ramamoorthy A, Wu CH, Opella SJ. Experimental aspects of multidimensional solid-state NMR correlation spectroscopy. J. Magn. Reson. 140 (1999) 131-140. Link
(4) Lee D-K, Santos JS, Ramamoorthy A. Nitrogen-15 chemical shift anisotropy and 1H-15N dipolar coupling tensors associated with the phenylalanine residue in the solid-state. Chem. Phys. Lett. 309 (1999) 209-214. Link
(3) Lee D-K, Santos JS, Ramamoorthy A. Application of one-dimensional dipolar-shift solid-state NMR spectroscopy to study the backbone conformation of membrane-associated peptides in phospholipid bilayers. J. Phys. Chem. B 103 (1999) 8383-8390. Link
(2) Hallock KJ, Lee D-K, Ramamoorthy A. Carbon-13 chemical shifts and 1H-13C dipolar couplings in metal sandwich solids using one-dimensional solid-state NMR spectroscopy. Chem. Phys. Lett. 302 (1999) 175-180. Link
(1) Lee D-K, Ramamoorthy A,Determination of the solid-state conformations of polyalanine using magic-angle spinning NMR spectroscopy. J. Phys. Chem. B 103 (1999) 271-275. Link