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Biophysics 930 N. University Ave. Ann Arbor, MI, 48109 (734) 763-9318Website
Current research
Current research
Structural misfolding of amyloid proteins, including A-beta and amylin.
Education
Education
B.Pharmaceutical - Madras medical college
M.Tech ( Industrial biotechnology) - Anna university
Ph.D. (NMR chemical exchange) - National university of Singapore
Academics
Academics
Post-doctoral fellow: April 2011 - present
PI: Ramamoorthy, University of Michigan
Post-doctoral fellow: January 2010 - April 2011
PI: Smita Mohanty, Auburn University
Ph.D. research: August 2005 - January 2010
PI: Henry Mok and Yang Daiwen, National University of Singapore
Publications
Publications
1) Janarthanan Krishnamoorthy, Victor C. K. Yu, Yu-Keung Mok. Auto-FACE: An NMR Based Binding Site Mapping Program for Fast Chemical Exchange Protein-Ligand Systems, February 18, 2010, PLoS ONE 5(2): e8943.
2) Janarthanan Krishnamoorthy, Smita Mohanty. OPEN-ITC: An alternate computational approach to analyze the ITC data of complex binding mechanisms, November 2011, Journal of Molecular Recognition 24(6):pg 1056-1066.
Poster and oral presentation
Poster and oral presentation
Title: A novel computational approach for analyzing the binding site of Bcl-2 family proteins using NMR spectroscopic data (poster)
Venue and date: May 2008, Italy Ciocco.
Chair persons: Rafael Bruschweiler, Stephan Grzeseik
Organized by: Gordon conference
Title: Calculation of NMR relaxation parameters using Redfield-theory (Application in Protein-ligand interaction)
Venue and date : December 2008, Singapore
Chair persons: Steve Pascal
Organized by: 13th Biological graduate Conference, NUS.
Book
Book
1) Janarthanan Krishnamoorthy, Yu-Keung Mok. NMR chemical exchange in mapping the protein-ligand binding site, https://www.morebooks.de/store/gb/book/nmr-chemical-exchange-in-mapping-the-protein-ligand-binding-site/isbn/978-3-8443-9735-2, LAP LAMBERT Academic Publishing (2011-05-20)
Award
Award
- Best mentorship award - Singapore government (Nov 2005)
- Astar assistanceship - Decoding Autodock4.2 to incorporate experimental constraint (Dec 2009 - Jan 2010)
Software developed
Software developed
- Auto-Face: Chemical shift analysis for fast exchange regimes
- Auto-Mex: Transitional probability based line-shape analysis for all chemical exchange regimes
- Open-ITC: ITC data analysis for complex binding mechanisms
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