Krishnarjuna Bankala, Ph.D.


2016 - Ph.D., Monash Institute of Pharmaceutical Sciences (MIPS), Monash University, Melbourne, Australia

Research Interests

Protein Biochemistry, NMR Spectroscopy, Peptide and Protein Structure, Polymer Nanodiscs and Membrane Proteins.


1) Swain M, Thirupathi R, Krishnarjuna B, Eaton EM, Kibbey MM, Rosenzweig SA, Atreya HS (2010) Spontaneous and reversible selfassembly of a polypeptide fragment of insulin-like growth factor binding protein-2 into fluorescent nanotubular structures. Chem Commun (Camb) 46, 216-218.

2) Krishnarjuna B, Jaipuria G, Thakur A, D’Silva P, Atreya HS (2011) Amino acid selective unlabeling for sequence specific resonance assignments in proteins. J Biomol NMR 49, 39-51.

3) Krishnarjuna B, Ganjiwale A, Manjappara U, Raghothama S (2011) NMR Structure implications of enhanced efficacy of obestatin fragment analogs. Int J Pept Res Ther 17, 259-270.

4) Kaushik S, Krishnarjuna B, Raghothama S, Aggarwal S, Raghunathan V, Ganjiwale A (2012) Theoretical and in vitro studies of a Cterminal peptide from PGKC of Leishmania mexicana mexicana. Mol Biochem Parasitol 185, 27-35.

5) Narayan P, Krishnarjuna B, Vishwanathan V, Jagadeesh Kumar D, Babu S, Ramanathan KV, Easwaran KRK, Nagendra HG, Raghothama S (2013) Does aluminium bind to histidine? An nmr investigation of amyloid β12 and amyloid β16 fragments. Chem Biol Drug Des 82, 48-59.

6) Lim SS, Yang W, Krishnarjuna B, Kannan Sivaraman K, Chandrashekaran IR, Kass I, MacRaild CA, Devine SM, Debono CO, Anders RF, Scanlon MJ, Scammells PJ, Scanlon MJ, Norton RS and McGowan S (2014) Structure and dynamics of apical membrane antigen 1 from Plasmodium falciparum FVO. Biochemistry 53,7310-7320.

7) MacRaild CA, Zachrdla M, Andrew D, Krishnarjuna B, Nováček J, Žídek L, Sklenář V, Richards JS, Beeson JG, Anders RF and Norton RS (2015) Conformational dynamics and antigenicity in the disordered malaria antigen merozoite surface protein 2. PLoS ONE 10, e0119899.

8) Morales RAV, MacRaild CA, Seow J, Krishnarjuna B, Drinkwater N, Rouet R, Anders RF, Christ D, McGowan S and Norton RS (2015) Structural basis for epitope masking and strain specificity of a conserved epitope in an intrinsically disordered malaria vaccine candidate. Sci Rep (Nature) 5,10103.

9) Krishnarjuna B, Andrew D, MacRaild CA, Morales RAV, Beeson JG, Anders RF, Richards JS and Norton RS (2016) Straintranscending immune response generated by chimeras of the malaria vaccine candidate merozoite surface protein 2. Sci Rep (Nature) 6, 20613.

10) Krishnarjuna B, Lim SS, Devine SM, Debono CO, Lam R, Chandrashekaran IR, Jaipuria G, Yagi H, Atreya HS, Scanlon MJ, MacRaild CA, Scammells PJ and Norton RS (2016) Solution NMR characterization of apical membrane antigen 1 and small molecule interactions as a basis for designing new antimalarials. J Mol Recognit 29, 281-291.

11) Seow J, Morales RAV, MacRaild CA, Krishnarjuna B, McGowan S, Dingjan T, Jaipuria G, Rouet R, Wilde KL, Atreya HS, Richards JS, Anders RF, Christ D, Drinkwater N, and Norton RS (2017) Structure and characterisation of a key epitope in the conserved Cterminal domain of the malaria vaccine candidate MSP2. J Mol Biol 429, 836-846.

12) Chittoor B, Krishnarjuna B, Morales RAV, MacRaild CA, Sadek M, Leung EWW, Robinson SD, Pennington MW, Norton RS (2017). The single disulfidedirected βhairpin fold. dynamics, stability, and engineering. Biochemistry 56, 2455-2466.

13) Das SC, Morales RAV, Seow J, Krishnarjuna B, Dissanayake R, Anders RF, MacRaild CA, Norton RS (2017). Lipid interactions modulate the structural and antigenic properties of the C-terminal domain of the malaria antigen merozoite surface protein 2. FEBS J 284, 2649-2662 (Special Issue: Malaria).

14) Sharma G, Moria N, Williams M, Krishnarjuna B, Pouton CW (2017) Purification and characterization of adenovirus core protein VII: a histonelike protein that is critical for adenovirus core formation. J Gen Virol 98, 1785-1794.

15) Krishnarjuna B, MacRaild CA, Sunanda P, Morales RAV, Peigneur S, Macrander J, Yu HH, Daly M, Raghothama S, Dhawan V, Chauhan S, Tytgat J, Pennington MW, Norton RS (2017). Structure, folding and stability of a minimal homologue from Anemonia sulcata of the sea anemone potassium channel blocker ShK. Peptides 99, 169178.

16) Krishnarjuna B, Chandra K, and Atreya HS (2018). Accelerating NMRbased structural studies of proteins by combining amino acid selective unlabeling with fast NMR methods. Magnetochemistry 4, 2 (Special Issue: Nuclear Magnetic Resonance Spectroscopy).

17) Krishnarjuna B, VillegasMoreno J, Mitchell ML, Csoti A, Peigneur S, Amero C, Pennington MW, Tytgat J, Panyi G and Norton RS (2018). Synthesis, folding, structure and activity of a predicted peptide from the sea anemone Oulactis sp. with an ShKT fold. Toxicon 150, 559.

18) Krishnarjuna B, Sugiki T, Morales RAV, Seow J, Fujiwara T, Wilde KL, Norton RS and MacRaild CA (2018). Transient antibodyantigen interactions mediate the strainspecific recognition of a conserved malaria epitope. Nature Commun Biol 1, 58.

19) Sunanda P, Krishnarjuna B, Peigneur S, Mitchell ML, Estrada R, VillegasMoreno J, Pennington MW, Tytgat J and Norton RS (2018). Identification, chemical synthesis, structure, and function of a new K V 1 channel blocking peptide from Oulactis sp. Pep Sci 110, e24073.

20) Akter M, Drinkwater N, Devine SM, Drew SC, Krishnarjuna B, Debono CO, Wang G, Scanlon MJ, Scammelles PJ, McGowan S, MacRaild CA and Norton RS (2019). Identification of the binding site of apical membrane antigen 1 (AMA1) inhibitors using a paramagnetic probe. ChemMedChem (Published online).

21) Singh M, Kishore A, Maity D, Sunanda P, Krishnarjuna B, Vappala, S, Raghothama S, Kenyon L, Pal D and Sarma JD (2019) A proline insertion-deletion in the spike glycoprotein fusion peptide of mouse hepatitis virus strongly alters neuropathology. J Biol Chem 294:8064-8087.

22) Elnahriry KA, Wai DCC, Krishnarjuna B, Badawy NN, Chittoor B, MacRaild CA, Williams-Noonan BJ, Surm JM, Chalmers DK, Zhang AH, Peigneur S, Mobli M, Tytgat J, Prentis P, Norton RS. Structural and functional characterisation of a novel peptide from the Australian sea anemone Actinia tenebrosa. Toxicon 168:104-112.

23) Chittoor B., Krishnarjuna B., Morales R.A.V., Norton R.S., The Disulfide-directed β‑hairpin fold: role of disulfide bond in forming and effect of an additional disulfide bond on stability, 2020, Aust. J. Chem.

Oral Presentation and Posters