Meng Zhang

Education

• 2007 - 2011 B.S. in Chemistry, Nankai University, China
• 2011 - Present Ph.D. Candidate in Chemistry, University of Michigan, USA

Publications

• Meng Zhang, Stéphanie V Le Clair, Sang-Choul Im, Lucy Waskell, and Ayyalusamy Ramamoorthy, Insights into the Role of Substrates on the Interaction between Cytochrome b₅ and Cytochrome P450 2B4 by NMR, Sci. Rep. 2015, 5: 8392
• Meng Zhang, Rui Huang, Sang-Choul Im, Lucy Waskell, and Ayyalusamy Ramamoorthy, Effects of Membrane Mimetics on Cytochrome P450 – Cytochrome b₅ Interactions Characterized by NMR Spectroscopy, J Biol Chem. 2015, 290(20):12705-18
• Meng Zhang, Rui Huang, Rose Ackermann, Sang-Choul Im, Lucy Waskell, Anna Schwendeman and Ayyalusamy Ramamoorthy, Reconstitution of Cytb₅–CytP450 Complex in Nanodiscs for Structural Studies by NMR. Angewandte Chemie in press
• Meng Zhang, Stéphanie V Le Clair, Yamamoto Kazutoshi, Rui Huang, Sang-Choul Im, Lucy Waskell, and Ayyalusamy Ramamoorthy, The cytb₅ linker region modulates the interaction with CYP2B4 both in their soluble and transmembrane domains. manuscript in preparation
• Meng Zhang, Rui Huang, Sang-Choul Im, Lucy Waskell, and Ayyalusamy Ramamoorthy, High-resolution structural interaction between cytochrome P450 and the FMN domain of cytochrome P450 reductase probed by NMR Spectroscopy, manuscript in preparation
• Rui Huang, Meng Zhang, Freeborn Rwere, Lucy Waskell, and Ayyalusamy Ramamoorthy, Kinetic and Structural Characterization of the Interaction between the FMN Binding Domain of Cytochrome P450 Reductase and Cytochrome c, J Biol Chem. 2015 ,290(8):4843-55
• Rui Huang, Meng Zhang, Yamamoto Kazutoshi, Sang-Choul Im, Lucy Waskell, and Ayyalusamy Ramamoorthy, Dynamic interaction between membrane bound full length Cytochrome P450 and FMN binding domain of CPR observed by solid-state NMR spectroscopy. Manuscript in preparation
• Rui Huang, Yamamoto Kazutoshi, Meng Zhang, Nataliya Popovych, Sang-Choul Im, Lucy Waskell, and Ayyalusamy Ramamoorthy, Probing the transmembrane structure and dynamics of microsomal cytochrome P450 reductase by solid-state NMR. Biophys. J.106(2014), 2126-2133.
• Huimin Li, Jingmin Zhou, Wei Shi, Xuejing Zhang, Zhenjie Zhang, Meng Zhang, and Peng Cheng, Structural Diversity of Four New Metal-Organic Frameworks with a Curving Tetracarboxdiimide Dicarboxylic Acid. CrystEngComm, 2014,16, 834-841

Presentations

• “Effect of membrane on the structure and function of a membrane-bound rabbit Cytochrome P450 2B4”, the 2013 GLDMDG meeting, Toledo, Ohio, May 9^th – May 10^th, 2013
• “NMR studies of interaction between Cytochrome P450 2B4 and the FMN binding domain of Cytochrome P450 Reductase”, the 18^th International Conference on Cytochrome P450, Seattle, Washington, June 18^th – 23^rd, 2013
• “Membrane preference of a membrane-bound rabbit Cytochrome P450 2B4 and its effect on CYP 2B4 structure and function indicating the presence of a hydrophobic substrate channel within the protein”, the 6^th Vaughan Symposium, Ann Arbor, Michigan, July 12^th, 2013
• “NMR Investigations of the Roles of Membrane and CYP-2B4 transmembrane-domain in the Interaction between CYP-2B4 and Its Redox Partners”, the 55^th Experimental Nuclear Magnetic Resonance Conference, Boston, Massachusetts, March 22^nd – 28^th, 2014
• “Roles of Membrane and Substrate on the Biological Function of Cytochrome P450”, the 7^th Vaughan Symposium, Ann Arbor, Michigan, July 30^th, 2014
• “Incorporation of the CYP2B4-cytb₅ complexes into nanodiscs characterized by NMR”, the the 56^th Experimental Nuclear Magnetic Resonance Conference, Pacific Grove, California, April 19^th – 24^th, 2015; the 2015 GLDMDG meeting, Ann Arbor, Michigan, May 7th – May 8th, 2015
• “Solution NMR study reveals the structure and dynamics of complex formation between cytochrome P450 and its redox partners”, the 2016 GLDMDG meeting, Chicago, May 5^th – May 6^th, 2016

Oral Presentations

• “Investigating the effect of membranes on complex formation between cytochrome P450 and cytochrome b₅”, the Recent Advances in Biomolecular NMR Spectroscopy international symposium, Ann Arbor, Michigan, April 16^th – 17^th, 2016

Academic Award

• Student Travel Award at 55^th Experimental Nuclear Magnetic Resonance Conference (March 2014)
• Chemistry Winter Fellowship by Department of Chemistry, University of Michigan (Winter 2015)
• The Robert W. Parry Award for Research by Department of Chemistry, University of Michigan (Summer 2015)
• The Margaret & Herman Sokol Graduate Summer Research Fellowship by Department of Chemistry, University of Michigan (Summer 2016)