Sam Kotler

Biophysics 930 N. University Ave. Ann Arbor, MI, 48109-1055 (734) 763-9318


Biophysics Ph.D. Pre-Candidate, University of Michigan-Ann Arbor

M.S. in Mechanical Engineering, University of California-San Diego, 2011

B.S. in Physics, Lake Forest College, Lake Forest, IL, 2009


The role of membrane composition on Abeta-membrane interactions.


  • Capone R, Jang H, Kotler, SA, Connelly L, Teran Arce F, Ramachandran S, Kagan BL, Nussinov R, and Lal R. (2012) All-d-Enantiomer of beta-Amyloid Peptide Forms Ion Channels in Lipid Bilayers, J Chem Theory Comput 8, 1143-1152.
  • Capone R, Jang H, Kotler SA, Kagan BL, Nussinov R, Lal R. (2012) Probing Structural Features of Alzheimer’s Beta-Amyloid Pores Using Site Specific Amino Acid Substitutions. Biochemistry 51, 776-785.
  • Connelly LS, Arce FT, Jang H, Capone R, Kotler SA, Ramachandran S, Kagan BL, Nussinov R, Lal R. (2012) Atomic Force Microscopy and MD Simulations Reveal Pore-Like Structures of All-D-Enantiomer Beta-Amyloid Peptide: Relevance to the Ion Channel Mechanism of AD Pathology. J. Phys. Chem. B 116. 1728-1735.

Abstracts and Presentations

  • Capone R, Kotler SA, Jang H, Connelly L, Nussinov R, Lal R. Oral Presentation: Probing Structural Features of Alzheimer’s β-Amyloid Channels in Membranes Using Aβ Mutants. Biophysical Society Meeting 2011. Biophys. J. Suppl 100(3) pp. 350a, 1897-Plat.